M. Alpsten

Sahlgrenska University Hospital

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Sven Ekholm

University of Rochester Medical Center

Göran Starck

University of Gothenburg

ÅA

Å. Appelqvist

Chalmers University of Technology

Eva Forssell‐Aronsson

University of Gothenburg

G. Astner

Aarhus University

B. Jonson

Chalmers University of Technology

Ingvar Bosæus

Sahlgrenska University Hospital

L. Ivarsson

Sahlgrenska University Hospital

P.G. Hansen

Michigan State University

Lars Lönn

Copenhagen University Hospital

Cooperative Institutions

Sahlgrenska University Hospital

103

University of Gothenburg

Lund University

Uppsala University

Karolinska Institutet

Chalmers University of Technology

European Organization for Nuclear Research

Umeå University

AstraZeneca (Sweden)

Linköping University

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The distribution of fibrinogen and platelets in rats after treatment with dextran 1000 and heparin.

PubMed (1973)

L. Ivarsson Nolte Wj M. Alpsten Rudenstam Cm

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Citations (1)

The Effect Of Tranexamic Acid On Experimental Gastric Haemorrhage

Thrombosis and Haemostasis (1981)

Björn Stenberg M. Alpsten Thomas Kjellström Bo Risberg

The etiology of gastric haemorrhage is manifold. Defects in the haemostatic balance can provoke or sustain bleeding. The role of the fibrinolytic system has been debated. Some clinical studies indicate the value of antifibrinolytic treatment. It was the purpose of the present investigation to study the effectiveness of antifibrinolytic treatment in reducing gastic haemorrhage from experimentally induced ulcerations in rats. Methods. Gastric ulcerations were induced in 47 rats by pyloric ligation and intragastric instillation of 1.0 N HCI. Red blood cells were labelled with 51cr. The rats were divided in two groups: one group received tranexamic acid 60 mg per 100 g b.w. and the other group received corresponding amount normal saline. The rats were followed for 6 hours after ligation at which time the stomachs were removed and examined for the volume and radioactivity of the gastric content. Results. Six hours after pyloric ligation all rats had ulcers in the glandular part of the stomach. The volume of the gastric content in the control group was 15.1 ± 1.0 and in the tranexamic acid group 8.9 ± 2.2 ml (M±SE, p<0.01). The total amount of haemorrhage in the control group was 0.30 ± 0.02 and in the tranexamic acid group 0.21 ± 0.02 ml(M±SE, p<0.005) Conclusions. Our earlier studies demonstrated increased mucosal fibrinolytic activity after induced gastric ulcerations. Reduction of the increased muosal fibrinolysis by tranexamic acid in the present study significantly reduced the gastric haemorrhage.

Antifibrinolytic

10.1055/s-0038-1653170

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Citations (1)

Evaluation of Volume Selection Methods in in Vivo MRS

Acta Radiologica (1995)

Göran Starck R. Lundin Eva Forssell‐Aronsson Marie Arvidsson M. Alpsten

In vivo MR spectroscopy (MRS) requires some kind of volume selection method to be able to measure the signal from a selected part of the body. To be able to interpret the spectra correctly, the quality of the volume selection must be investigated for each new MRS application using phantom measurements. A new phantom, especially suitable for precision measurements of the volume selection performance, is presented. It contains a small, remotely controlled signal source placed inside a larger vessel. This principle can be applied to various body regions, coil types and nuclei. The measurement conditions are close to the clinical situation. The phantom does not have to be repositioned during a signal profile measurement and the signal contribution from each point along the profile is determined regarding sign and amplitude.

SIGNAL (programming language)

10.1177/028418519503600321

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Citations (10)

Intratumor distribution of vascular and extravascular spaces

Microvascular Research (1980)

Linnéa Karlsson M. Alpsten K.L. Appelgren H.-I. Peterson

Plasma volume

Distribution Volume

10.1016/0026-2862(80)90084-9

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Citations (14)

Point-wise measurements of MRS volume selection performance are insensitive to magnetic susceptibility effects of phantom materials

Magnetic Resonance Imaging (2000)

Göran Starckab Maria Ljungberg Barbro Vikhoff‐Baaz M. Alpsten Sven Ekholm

SIGNAL (programming language)

10.1016/s0730-725x(00)00184-3

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Citations (1)

Effect of Roux-en-Y gastroenterostomy on gastric emptying of a solid meal following antrectomy and vagotomy.

PubMed (1986)

Lars Lundell M. Alpsten Daniel P. Andersson

Gastric emptying of a 51Cr labelled solid meal was studied before and at least 6 months after operation for pyloric-prepyloric ulcer disease. All patients underwent an antrectomy, selective gastric vagotomy but 10 were randomized to a gastroduodenostomy and 12 to a Roux-en-Y gastrojejunostomy. There was no significant difference in the emptying rate between patients studied preoperatively (T 75 = 48 +/- 21.8 min) and those investigated after a Billroth I gastroduodenostomy (T 75 = 45 +/- 15.8 min). However, the emptying rate was significantly retarded in the Roux-en-Y patients as compared to those studied preoperatively (T 75 + T 50 + T 25). In the former group, an initial retardation of emptying of the meal was most apparent (T 75 = 89 +/- 81.7 min). Due to a high standard deviation, the difference between the Roux-en-Y and gastroduodenostomy groups did not reach statistical significance. Our results would indicate that retarded gastric emptying is not a regular phenomenon after a Roux-en-Y gastrojejunostomy provided that a selective gastric vagotomy had been performed and the investigation been carried out at least 6 months after the operation.

Gastroenterostomy

Billroth II

Roux-en-Y anastomosis

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Citations (4)

The alpha decay of 179Hg and 178Hg

Nuclear Physics A (1971)

P.G. Hansen B. Jonson J. Ż̷ylicz M. Alpsten Å. Appelqvist

Alpha decay

Alpha (finance)

Branching fraction

10.1016/0375-9474(71)90144-8

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Citations (30)

A comparison of different methods to measure body composition in patients

Applied Radiation and Isotopes (1998)

J Tölli B.‐Å. Bengtsson Ingvar Bosæus Gudmundur Johansson M. Alpsten

Bioelectrical Impedance Analysis

Body water

Dual energy

Dual-Energy X-ray Absorptiometry

Fat free mass

10.1016/s0969-8043(97)00225-x

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Citations (9)

A gamma camera for measurements of internal contamination after a radiological accident

Journal of Radiological Protection (1999)

E. Wallström M. Alpsten S. Mattsson

After a radiological accident with the release of large amounts of radionuclides into the environment, measurements of the external and internal exposure of the public will be urgently required. The aim of this study was to investigate the properties of a gamma camera with regard to measurements of internal contamination. The gamma camera was used as a detector without any imaging function. The lowest minimum detectable activity, 100 Bq 131I in thyroid measured over the neck and 400 Bq 137Cs in the whole body measured over the trunk (1 min measuring time), was found when using the lowest (50 keV-450 keV) energy interval among the three investigated (also 550-750 keV and 450-550 keV), in measurements without a collimator. The mechanical difficulties in handling a gamma camera without a collimator may also have to be considered. It is essential to pay attention to the influence of body size on both background and sensitivity. Provided proper calibrations are carried out and routines for measurements are established, a gamma camera is useful for fast identification and quantification of internal contamination with gamma-emitting radionuclides down to levels so low that in most situations they give a low contribution to the effective dose.

Gamma camera

Collimator

Internal dose

radioactive contamination

Radiation monitoring

10.1088/0952-4746/19/2/304

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Citations (7)

Estimation of Whole-body content of 137Cs from a Single Urine Sample. Experiance from Areas in Russia Contaminated after the Chernobyl Accident

Radiation Protection Dosimetry (2000)

C. Thornberg E. Wallstr m И. А. Звонова T. Ješko R. Vesanen

Between 1991 and 1997 measurements of the body burden of 137Cs were performed in people living in the Bryansk region of Russia. A single urine sample was also collected for many of the measured persons. The possibility of estimating the whole-body 137Cs from a single urine sample was investigated by comparing the body burden of 137Cs derived from field measurements with data on the urinary excretion of 137Cs, using various normalisation parameters. Coefficients for assessing the body burden from a single urine sample were calculated for each method. The in vivo measurements were carried out using a 63 mm diam. x 63 mm NaI(Tl) detector and a single-channel analyser in villages in the Bryansk region of Russia, in September each year. The urine samples were collected from adults as well as from children, and later analysed for 137Cs, potassium and creatinine concentrations. The correlation between whole-body content and urinary excretion of 137Cs did not improve by introducing potassium or creatinine normalisation. This study indicates that the most reliable method to estimate 137Cs body burden from urine analysis is simply to use the concentration of 137Cs. Age and sex dependent factors for the calculation of 137Cs body burden from a single urine sample are presented.

Urine sample

Sample (material)

Urine collection device

10.1093/oxfordjournals.rpd.a033041

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Citations (3)