Hisao Nakasaki

Tokai University

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[Immunosuppressive acidic glycoprotein (IAP) and immunosuppressive substance].

PubMed (1983)

Kyoji Ogoshi Y Kondoh Hisao Nakasaki T Tajima Toshio Mitomi

Serum IAP and IS levels were studied in patients with stomach cancer. We found that the serum levels of IAP and IS increased as the disease progressed; their true positive rates as tumor markers were 49.3% and 39.8%, respectively. There was some delicate difference between these glycoproteins and T-cell subpopulation. IAP and IS correlated well with a correlation coefficient of 0.847, their value in clinical oncology are thought to be equivalent. Some difference was found between their substances and ASP, this might indicate the heterogeneous nature of the circulating glycoproteins in varying cancer-bearing status.

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Citations (9)

A CASE OF TUBERCULOUS ABSCESS OF THE NECK PROMPTLY DIAGNOSED BY POLYMERASE CHAIN REACTION METHOD

The journal of the Japanese Practical Surgeon Society (1993)

Masatoshi Ohta Yutaka Tokuda Yuko Yanagita Soichi Kuge A. Okumura

We experienced a case of abscess of the neck caused by Mycobacterium tuberculosis, which was precisely diagnosed by the polymerase chain reaction (PCR) method. A 67-year-old woman was seen at the hospital because of a swelling in the right anterior region of the neck which was noticed 3 weeks before and then associated with skin redness and hot sensation. On physical examination, along the lateral edge of the right sternocleidomastoid muscle, a fixed and elastic-hard mass measured 6.5×4.5cm was palpated without tenderness. Although needle aspiration of the mass revealed a purulent content, microscopic examination demonstrated no causative microorganisms including mycobacteria and aerobic bacteria. Histology of the mass was necrotizing lymphadenitis without granulation. Since PPD reaction was strongly positive, tuberculosis was highly suspected. The PCR method successfully detected the DNA specific to tubercle bacillus from the neck mass. Subsequently anti-mycobacterial therapy was started without any delay and the mass regressed.

Neck mass

Sternocleidomastoid muscle

10.3919/ringe1963.54.1497

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Predicting recurrence and metastasis of primary esophageal cancer with or without lymph node metastasis

Oncology Reports (2006)

Takayuki Tajima Masaya Mukai Shinkichi Sato Hiromi Ninomiya Kanako Wakui

Occult

10.3892/or.15.4.809

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Citations (3)

Criteria for predicting the recurrence and metastasis of stage I and II gastric cancer without lymph node metastasis

Oncology Reports (2004)

Masaya Mukai Shinkichi Sato Tomomi Kimura Nobukazu Komatsu Hiromi Ninomiya

Occult

10.3892/or.12.1.59

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Citations (3)

P4-16 A Case of Clear Cell Hepatocellular Carcinoma

ACTA HISTOCHEMICA ET CYTOCHEMICA (2002)

Shinkichi Sato Yasuhisa Oida Masaya Mukai Hisao Nakasaki Kenji Kawai

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Study of Tumor-Associated Carbohydrate Antigens in Colonic Cancers. Immunohistochemical Analysis by Monoclonal Antibodies.

Nihon Daicho Komonbyo Gakkai Zasshi (1994)

Hisao Nakasaki Tomoyuki Okumura M Miyaji Masateru Ohta Kimimasa Tobita

異なる糖鎖を認識する複数のモノクローナル抗体(MoABと略)を用い,大腸正常粘膜,大腸腺腫,絨毛腺腫,早期癌,進行癌,および転移性肝癌でこれらの糖鎖の多様性を免疫組織学的染色法により検討した。各MoABの認識する糖鎖は癌組織の進行度により異なった発現形態を示した.MoAB-SH 1の局在は正常粘膜と大腸腺腫では認められず,絨毛腺腫で強い異型性を示す組織に僅かに局在が認められるが早期癌では癌細胞に有意(27%)に局在を認めた.癌の進展に伴う進行癌(84%)および転移性肝癌(78%)で染色率の上昇が認められた.MoAB-AH 4, MoAB-AH 6でも陽性率はMoAB-SH 1と同様に癌の進行に伴って上昇の傾向を示した.MoAB-FH 6は早期癌では比較的高い陽性率(53%)を認めるが癌の進行により低下の傾向(進行癌=33%,転移性肝癌=33%)を示した.MoAB-TKH 2は進行癌,早期癌とも陽性率は低く2者間に差はなかった.進行癌と転移性肝癌は同一癌組織内に複数のMoABの染色性の混在が認められ,相補分布性(mosaicism)が認められた.これらの結果は癌発生初期のいわゆるcarcinoma in situの状態の糖鎖構造が癌の増殖,進展に伴い,より複雑な糖鎖構造を形成するようになり,癌の多相性(heterogeneity)を,獲得していくものと推察された.

10.3862/jcoloproctology.47.1002

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Analysis of the tissue and cellular localization of alpha-1-antichymotrypsin by an immunohistochemical technique.

PubMed (1982)

S Takada Masaya Tsuda Toshio Mitomi Hisao Nakasaki T Noto

The cellular localization of alpha-1-antichymotrypsin (alpha 1-ACT) was studied immunohistochemically using rabbit HRP-labeled Fab' against human alpha 1-ACT. alpha 1-ACT was found in cell nuclei of carcinomas of the stomach, liver, breast, pancreas and leiomyosarcoma and in cell nuclei of lymphoid cells infiltrated into the stomach carcinoma mass. alpha 1-ACT was not found in carcinoma cells of the colon, uterus, rectum or esophagus, or in lymphoid cells infiltrated into the rectal carcinoma mass or into inflammatory regions such as gastric ulcers or appendicitis. Further, alpha 1-ACT was not found in normal cells around the carcinoma mass or in normal tissues.

Alpha (finance)

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Citations (12)

High-dose chemotherapy supported by autologous bone marrow transplantation in solid tumors.

PubMed (1983)

Tomoo Tajima Hiroki Sonoda Yutaka Tokuda Mitsuhiro Kubota Teruji Sugita

High-dose chemotherapy supported by autologous bone marrow transplantation (ABMT) was given 34 times on twenty six patients with solid tumor. Excluding 6 patients with adjuvant use and 2 patients with non-evaluable lesion, the response rate (CR + PR) of 44.4% was observed among 18 evaluable patients with advanced solid tumor. The results seem to be quite significant since many of the patients had become refractory to conventional treatments and intensity of chemotherapy was still moderate in some of the patients. ABMT following a course of chemotherapy is a promising approach of overcoming the toxic limitations of intensive chemotherapy since a dose-response relationship exists in many situations of cancer chemotherapy and ABMT appears to prevent fatal myelosuppression.

Solid tumor

Refractory (planetary science)

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Citations (7)

Two Cases of Segmental Aganglionosis of Colon by a Degenerative Disorder of Myenteric Plexus.

Nihon Daicho Komonbyo Gakkai Zasshi (1997)

Hisao Nakasaki H. Moriya Mineto Ohta Jinichi Soeda Hidehiro Tokunaga

症例1は63歳男性.6年前に多発性骨髄腫で2年間化学療法治療を受けた.同疾患の再発は認めず6年経過している.最近腹部膨満著明で高度の便秘を主訴として来院した.注腸造影で下降結腸の狭小化,内視鏡での拡張不全を認めるが粘膜面は異常所見を認めなかった.メコリール試験は陽性であった.症例2は56歳,女性.17年前に限局性巨大結腸症で脾屈曲部の大腸の拡張部位の切除を受けたが症状の改善を認めなかった.高度の便秘で来院した.注腸造影で異常な拡張から狭小への移行,内視鏡検査で拡張不全と粘膜面の正常所見,メコリール試験陽性,前回手術標本の再検討で狭小部のaganglionosisが証明された.症例1および2は狭窄部を含めて結腸切除が施行された.組織学的検索でlocalized segmental aganglionosisと診断された.術後の経過は4年および2.5年を経過しているが順調である.

Degenerative Disorder

Plexus

10.3862/jcoloproctology.50.45

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Announcement

Digestive Surgery (1999)

J. Dadoukis J.M. Läuffer Gang Mai D. Berchtold C.G. Curti

10.1159/000018788

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