Gleison Vieira Duarte

Instituto Federal da Bahia

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André Vicente Esteves de Carvalho

Hospital Moinhos de Vento

Ricardo Romiti

Universidade de São Paulo

Ivonise Follador

Universidade Federal da Bahia

Thadeu S. Silva

Complexo Hospitalar Universitário Professor Edgard Santos

Renata Ferreira Magalhães

Universidade Estadual de Campinas (UNICAMP)

Maria Cecília Rivitti Machado

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Maria de Fátima S. P. de Oliveira

Universidade Federal da Bahia

Carolina M. Alves Cavalheiro

Universidade Federal da Bahia

Mayra Ianhez

Universidade Federal de Goiás

Bruno de Oliveira Rocha

Universidade Federal da Bahia

Cooperative Institutions

Universidade Federal da Bahia

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Hospital Ana Nery

John Wiley & Sons (United States)

Complexo Hospitalar Universitário Professor Edgard Santos

Oxfam

John Wiley & Sons (United Kingdom)

Hudson Institute

Universidade Federal de São Paulo

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The management of psoriasis through diet

Psoriasis Targets and Therapy (2012)

Gleison Vieira Duarte Barbosa Rosa

Abstract: Diet is an important factor in the management of several dermatological diseases, such as dermatitis herpetiformis, acne vulgaris, gout, phrynoderma, pellagra, psoriasis, and acrodermatitis enteropathica. New concepts have emerged concerning the influence of diet on psoriasis. For example, diet has an adjuvant role in the management of several cardiovascular comorbidities that exhibit a higher-than-expected prevalence in psoriatic patients. Functional foods, such as yellow saffron and fish oil, may exert favorable effects on immune and cardiovascular functions. A gluten-free diet may promote significant clinical and histologic improvement. Folate supplementation may induce clinical improvement of psoriasis, but side effects may also occur. Diets rich in fresh fruits and vegetables are associated with a lower prevalence of psoriasis, and vegetarian diets were associated with clinical improvement. Additionally, many drug-diet interactions (retinoids, methotrexate, cyclosporine) must be considered in patients with psoriasis. Therefore, in addition to current nutritional advice given to psoriasis patients, further studies are necessary in the role of diet in psoriasis therapy. Keywords: diet, lifestyle, psoriasis, recommendations, supplementation

Acrodermatitis enteropathica

Pellagra

Dermatitis herpetiformis

10.2147/ptt.s24755

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Citations (10)

Consensus on the treatment of hidradenitis suppurativa - Brazilian Society of Dermatology

Anais Brasileiros de Dermatologia (2019)

Renata Ferreira Magalhães Maria Cecília Rivitti Machado Gleison Vieira Duarte Roberto Souto Daniel Holthausen Nunes

Hidradenitis suppurativa is a chronic immune mediated disease of universal distribution that causes great damage to the quality of life of the affected individual, whose prevalence is estimated at 0.41% in the Brazilian population. The objective of this work was update on physiopathogenesis, diagnosis and classification of hidradenitis suppurativa and to establish therapeutic recommendations in the Brazilian reality. It was organized as a work group composed of eight dermatologists from several institutions of the country with experience in the treatment of hidradenitis suppurativa and carried out review on the topic. Recommendations were elaborated and voted by modified Delphi system and statistical analysis of the results was performed. The Brazilian consensus on the clinical approach of hidradenitis suppurativa had the support of the Brazilian Society of Dermatology.

Hidradenitis Suppurativa

Delphi Method

10.1590/abd1806-4841.20198607

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Citations (74)

Consenso Brasileiro de Psoríase 2020 e Algoritmo de Tratamento da Sociedade Brasileira de Dermatologia

Ricardo Romiti André Vicente Esteves de Carvalho Gleison Vieira Duarte

10.1016/j.abdp.2021.09.013

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Atualização do custo-efetividade por resposta de adalimumabe, etanercepte, guselcumabe, infliximabe, ixequizumabe, secuquinumabe e ustequinumabe no tratamento de psoríase em placas moderada a grave sob a perspectiva do Sistema de Saúde Suplementar brasileiro

Jornal Brasileiro de Economia da Saúde (2022)

Alexander von Reininghaus Rafael L. Gomes Bernardo R. Pires Juares Bianco Renato Picoli

Objetivo: Os agentes biológicos representam um grande avanço no tratamento da psoríase em placas moderada a grave. No entanto, variações de eficácia, segurança e custos dos tratamentos podem dificultar a escolha do agente terapêutico. Este estudo teve como objetivo atualizar o custo por resposta dos agentes biológicos disponíveis para psoríase no ROL de Procedimentos e Eventos em Saúde (ROL) da Agência Nacional de Saúde Suplementar (ANS). Métodos: Uma análise de custo por resposta foi utilizada para avaliar a razão de custo pelo desfecho Índice de Gravidade e Área da Psoríase (PASI) 90. Os resultados foram apresentados para o primeiro ano (ano I), que compreende a fase de indução e a fase manutenção até completar 52 semanas e foi realizada uma análise da efetividade do tratamento num cenário de orçamento fixo. Os custos dos tratamentos foram calculados com base nos preços de fábrica (PF18%) da Tabela da Câmara de Regulação do Mercado de Medicamentos de junho de 2021. Resultados: Para o ano I, o guselcumabe apresentou melhor resultado para custo por resposta (R$ 130.467) PASI 90, seguido por ixequizumabe, ustequinumabe, secuquinumabe, adalimumabe, infliximabe e etanercepte. No cenário com orçamento fixo, o guselcumabe demonstrou ser o agente capaz de tratar com sucesso (PASI 90) o maior número de pacientes. Conclusão: Sob a perspectiva do Sistema de Saúde Suplementar do Brasil, o guselcumabe apresentou o melhor custo por resposta PASI 90, sendo, assim, a terapia com melhor custo-efetividade no tratamento da psoríase em placas moderada a grave disponível no ROL.

10.21115/jbes.v14.n1.p56-62

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Psoríase e obesidade: revisão de literatura e recomendações no manejo: [revisão]

Anais Brasileiros de Dermatologia (2010)

Gleison Vieira Duarte Ivonise Follador Carolina M. Alves Cavalheiro Thadeu S. Silva Maria de Fátima S. P. de Oliveira

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Consensus on the therapeutic management of atopic dermatitis ‒ Brazilian Society of Dermatology: an update on phototherapy and systemic therapy using e-Delphi technique

Anais Brasileiros de Dermatologia (2023)

Raquel Leão Orfali Daniel Lorenzini Aline Lopes Bressan Anber Ancel Tanaka Ana Maria Mósca de Cerqueira

This publication is an update of the "Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology" published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript.

Systemic therapy

Delphi Method

10.1016/j.abd.2023.04.003

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Citations (5)

Correlation between psoriasis' severity and waist-to-height ratio

Anais Brasileiros de Dermatologia (2014)

Gleison Vieira Duarte Larissa Porto da Silva

In the absence of ideal biomarkers, the research for clinical markers correlated to the severity of psoriasis and/or its comorbidities becomes crucial. Recently, studies have shown positive correlation between body mass index and prevalence and severity of psoriasis. Abdominal circumference showed stronger correlation with disease severity than body mass index. We evaluated the waist-to-height ratio in a sample of 297 adult patients with psoriasis and observed that it has a significant correlation with body mass index and PASI, and together with body mass index allows the identification of central obesity, reducing its subdiagnosis.

Waist-to-height ratio

10.1590/abd1806-4841.20142854

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Citations (18)

Navigating the Multidimensional Impact of Living with Hidradenitis Suppurativa: An In-Depth Netnographic Study on Social Media Platforms

Dermatology and Therapy (2023)

Ericles Andrei Bellei André Vicente Esteves de Carvalho Beatriz Magalhães Eng Carla Tozato Danilo Hamilko de Barros

Hidradenitis suppurativa (HS) is a chronic skin condition causing considerable distress. It impacts mobility, social interaction, and quality of life. In Brazil, there is a notable gap in epidemiological data and patient experiences regarding HS. This study, spanning 2019 to 2022, employed netnography to probe the experiences of Brazilian patients with HS. This approach gleans insights from online interactions, offering a direct view into patients’ lives. Notably, the data illuminated the challenges patients face, such as difficulties in obtaining a diagnosis and the complexities involved in managing a chronic, and often debilitating, condition. Furthermore, patients’ experiences with various treatments, encompassing antibiotics, biologic agents, lifestyle alterations, surgical procedures, and alternative remedies, were also examined. By undertaking a longitudinal analysis of patient interactions, the study aimed to offer a richer understanding of HS, from its diagnosis to its treatment. It underscores the necessity for a more patient-centered approach when managing this condition. We hope that this enhanced understanding can facilitate better care for those affected by HS.

Hidradenitis Suppurativa

Netnography

10.1007/s13555-023-01032-9

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Citations (1)

Epidemiology and treatment of psoriasis: a Brazilian perspective

Psoriasis Targets and Therapy (2015)

Gleison Vieira Duarte Maria de Lourdes Aguiar Oliveira Larissa Porto-Silva

Psoriasis is a chronic immune-mediated systemic disease that is influenced by genetic and environmental factors, is associated with comorbidities, and has a negative impact on the quality of life of affected individuals. The prevalence of psoriasis varies among different ethnic groups, but this topic has not been studied in Brazil to date. In this review, we evaluate the epidemiology and treatment of psoriasis from a Brazilian perspective. We focused on studies that involved Brazilian subjects. The prevalence of psoriasis in Brazil is estimated to be 2.5%, but no population study has been performed previously. Environmental factors, such as tropical climate, in association with genetic factors, such as miscegenation, may exert a beneficial impact on the course and frequency of psoriasis in Brazil. A number of studies have advanced our understanding of the cardiovascular, ophthalmic, and oral comorbidities that are associated with psoriasis. Concerns about biological therapy, such as endemic leprosy, human T-cell lymphotropic virus (HTLV), and tuberculosis infections, are discussed. The nonavailability of treatment options for psoriasis in the public health system contradicts the Brazilian Society of Dermatology guidelines, stimulating the judicialization of access to medicines in psoriasis care.

10.2147/ptt.s51725

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Citations (16)

Elevated Serum Aldosterone Levels in Patients with Psoriasis and Systemic Arterial Hypertension: A Cross-Sectional Study

Research Square (Research Square) (2023)

Jennifer Pinheiro José Silva Gleison Vieira Duarte Luíse Ribeiro Daltro

Abstract Background Epidemiological studies suggest a higher prevalence of systemic arterial hypertension (HTN) and other cardiovascular diseases in patients with psoriasis. The underlying mechanism remains unclear, but may involve activation of the renin-angiotensin-aldosterone system (RAAS). This study aimed to compare renin and aldosterone levels between psoriasis patients and non-psoriasis individuals. Methods: A prospective, cross-sectional study enrolled consecutive patients from a university hospital’s dermatology outpatient clinic. Clinical evaluation was followed by blood collection for renin and aldosterone measurement, allowing for comparison between psoriasis and non-psoriasis patients. Subgroup analyses stratified participants based on HTN presence. Multiple linear regression analyses identified independent predictors of higher renin and aldosterone levels. Results: The study included 170 patients (mean age: 55 ± 13 years, 50.6% men, 85.9% non-white), 57.6% having psoriasis and 44.1% having HTN. Mean plasma renin levels were similar in psoriasis and non-psoriasis patients (26.3 ± 51.4 versus 23.9 ± 48.7 µUI/ml, respectively, p = 0.764). However, psoriasis patients showed significantly higher mean serum aldosterone levels (25.3 ± 49.4 versus 11.7 ± 10.7 ng/dl, p = 0.009). Stratification revealed that only psoriasis patients with HTN had significantly higher aldosterone levels compared to other subgroups. In multiple linear regression analyses, psoriasis was only associated with higher levels of aldosterone in hypertensive patients. Conclusions: This study indicates elevated serum aldosterone levels in patients with psoriasis and HTN. Further investigation is necessary to understand the potential impact of this finding on cardiovascular morbidity and mortality in psoriasis patients.

Plasma renin activity

Cross-sectional study

Outpatient clinic

Primary Aldosteronism

10.21203/rs.3.rs-3264184/v1

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