ÖK

Özlem Karakurt

Balıkesir University

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i-10 index

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Co-Authors

Ramazan Akdemir

Sakarya University

Harun Kılıç

Sakarya University

GÇ

Göksel Çağırcı

Antalya Eğitim ve Araştırma Hastanesi

Sadık Açıkel

University of Health Sciences

Mehmet Doğan

Erzincan University

Nuray Yazıhan

Ankara University

SÇ

Serkan Çay

Sağlık Bilimleri Üniversitesi

Asuman Biçer

Harran University

Asuman Biçer Yeşilay

Harran University

Serkan Topaloğlu

Sağlık Bilimleri Üniversitesi

Cooperative Institutions

Ministry of Health

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

Sağlık Bilimleri Üniversitesi

Türkiye Yüksek İhtisas Hastanesi

Ankara Yıldırım Beyazıt University

University of Health Science

Memorial Ankara Hospital

Sakarya University

Ankara University

University of Health Sciences

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Right ventricular function in ST elevation myocardial infarction: Effect of reperfusion

Clinical and investigative medicine (2009)

Özlem Karakurt Ramazan Akdemir

To investigate right ventricle function in successfully reperfused ST elevated myocardial infarction (STEMI) and to compare reperfusion strategies.From January 2007 to August 2008, 33 patients with anterior myocardial infarction (MI) and 48 patients with non-anterior myocardial infarction were enrolled in this study. Patients were treated with thrombolytic therapy (TT) or primary percutanaeous coronary intervention (PPCI) (Primary intervention: 16 and 25 patients (anterior and non-anterior consecutively), thrombolytic therapy: 17 and 23 patients (anterior and non-anterior consecutively)). Right ventricle (RV) function was analyzed using tissue Doppler investigation (TDI) after 72 hr of successful reperfusion.There was no difference in right ventricle function assessed by right ventricle TDI Tei index between the PPCI and TT group (0.39+/-0.20 vs. 0.39+/-0,17). RV TDI Tei index increased in anterior MI patients treated with either PPCI or TT compared with control group (0.39+/-0.11 vs. 0.27+/-0.16, P=0.015 and 0.43+/-0.18 vs. 0.27+/-0.16 , P= 0.014 respectively). RV TDI Tei index did not differ between non-anterior MI patients treated with either PPCI or TT and control group (0.38+/-0.23 vs. 0.27+/-0.16, and 0.37+/-0.16 vs. 0.27+/-0.16, respectively).RV function deteriorated in STEMI compared with healthy controls. Contrary to the expectation, RV dysfunction was observed in anterior STEMI, but not in non anterior MI. There was no difference in RV function between the two treatment modalities.

Reperfusion Therapy

Anterior wall

Doppler imaging

10.25011/cim.v32i4.6620

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Citations (7)

Asymmetric dimethylarginine levels in patients with coronary artery ectasia.

PubMed (2009)

Serkan Çay Göksel Çağırcı Murat Akçay Özlem Karakurt Erkan Kahraman

Endothelial dysfunction might be one of the pathophysiological mechanisms in the development of coronary artery ectasia (CAE) although the exact mechanisms have not yet been demonstrated. Asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase, is also related to endothelial and structural dysfunction.To asses the relationship between CAE and ADMA plasma concentrations.Thirty patients with CAE in a mean age of 55.5 +/- 3.6 years and 40 patients with normal coronary arteries in a mean age of 53.3 +/- 11.6 years were studied. The ADMA levels of all patients were analysed by ELISA method.The mean ADMA level in the CAE group was found to be significantly higher than the mean ADMA level in the normal coronary artery group (2.26 +/- 0.47 vs. 1.43 +/- 0.40 micromol/l, p < 0.001). The elevated ADMA level (> 1.80 micromol/l) was present in 83.0% of patients from the CAE group and 25.0% of patients from the normal coronary artery group (p < 0.001). Having an increased ADMA level enhanced the risk of CAE 15-fold. The multiple-adjusted OR of the risk of CAE was 18.71 (95% CI 4.95-70.68) for the higher ADMA level compared to the lower level.Asymmetric dimethylarginine level is significantly associated with the presence of coronary artery ectasia. These findings suggest that increased ADMA level may be associated with endothelial dysfunction leading to the development of coronary artery ectasia.

Coronary artery ectasia

Asymmetric dimethylarginine

Endothelial Dysfunction

Ectasia

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Psöriazis hastalarında artmıs QT dispersiyonu

Dicle Tıp Dergisi (2010)

Asuman Biçer Nurcan Başar Betül Banu Karasu Özlem Karakurt Harun Kılıç

Objectives: Psoriasis is a chronic infl ammatory skin disorder characterized by erythematous plaques, generally at the elbows, knees, scalp, umbilicus and lumber area. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the present study, we aimed to investigate QT dispersion (QTD) and corrected QT dispersion (QTcD) as a possible indicator of increased risk for ventricular arrhythmias and sudden cardiac death in patients with psoriasis. Materials and methods: Twenty-three patients with psoriasis and age and gender matched 20 control subjects were enrolled in the study. The severity of the disease was evaluated by the âPsoriasis Area and Severity Index (PASI)â. Standard 12-lead electrocardiographs at 25 mm/s paper speed and 24-hour holter examination were performed in all subjects. QTD and QTcD were measured. QTD was defi ned as the difference between the maximum and minimum QT interval measurements and QTc was calculated according to Bazett\'s formula. Correlation analysis was performed between QTD and QTcD and PASI and duration of the disease. Results: QTD and QTcD were signifi cantly greater in psoriatic patients than controls (QTD, 67.5}17.4 vs 44.0}11.9 ms, p

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Effect of reperfusion therapy on index of myocardial performance in acute myocardial infarction: thrombolytics versus primary angioplasty

Heart and Vessels (2010)

Ramazan Akdemir Özlem Karakurt Harun Kılıç Asuman Biçer Yeşilay Mehmet Doğan

Isovolumetric contraction

10.1007/s00380-009-1168-8

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Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology (2011)

Asuman Biçer Yeşilay Özlem Karakurt Ramazan Akdemir Gönül Erden Harun Kılıç

Thymosin beta4 (Tβ4) has been shown to have an important role in healing of damaged tissues and promoting cardiomyocyte survival in acute coronary syndromes. We evaluated endogenous Tβ4 levels in patients presenting with ST-elevation acute myocardial infarction (STEMI) before and after successful primary percutaneous coronary intervention (PCI).The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries. To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.Compared to controls, baseline levels of high-density lipoprotein cholesterol (46.2±8.9 vs. 34.2±7.2 mg/dl, p<0.001) and Tβ4 (2.9±1.5 vs. 1.5±1.0 µg/ml, p<0.001) were significantly lower, and white blood cell counts (7.6±2.2 vs. 11.4±3.0 10³/µl, p<0.001) were significantly higher in the STEMI group. After 48 hours of PCI, the mean Tβ4 level increased significantly to 2.3±0.8 µg/ml (p<0.001) and became similar to that of the control group (p=0.068). There was a significant negative correlation between serum Tβ4 and white blood cell count (r=-0.347, p=0.016).Considering the significant increase in serum Tβ4 levels following successful primary PCI in patients with STEMI, Tβ4 may prove to be a new marker in the assessment of reperfusion success in addition to those used currently.

White blood cell

10.5543/tkda.2011.01751

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Citations (6)

P‐Wave dispersion increases in prehypertension

Blood Pressure (2009)

Göksel Çağırcı Serkan Çay Özlem Karakurt Neslihan Eryasar Sadık Açıkel

Background. Prolongation of P‐wave durations and increased P‐wave dispersion are independent predictors of atrial fibrillation (AF). AF is the most common arrhythmia of the general population. Prehypertension, including those with systolic blood pressure ranging from 120–139 mmHg or diastolic blood pressure ranging from 80–89 mmHg was described by JNC7. Prehypertension is the predictor of development of hypertension in the future. Prehypertension is associated with excess cardiovascular morbidity and mortality. In this study, we evaluated relationship between prehypertension and P‐wave dispersion. Methods. Seventy‐eight prehypertensive patients (group 1: mean age 44.6±11.2 years; 45 male) and 78 normotensive patients (group 2: mean age 43.3±7.0 years; 43 male) were enrolled in this study. Standard 12‐lead ECGs were recorded in all patients using a paper speed of 50 mm/s. In all patients, transthoracic echocardiographic examination was performed. Results. Pmax and P‐wave dispersion were significantly higher in group 1 compared with group 2 (103.59±19.8 ms vs 93.59±13.4 ms, p<0.001; 50.51±18.6 ms vs 39.85±10.6 ms, p<0.001, respectively). Conclusion. Pmax and P‐wave dispersion increase in prehypertensive patients compared with normotensive patients. This data might show increased risk of AF in prehypertension.

Prehypertension

10.1080/08037050902779441

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Citations (29)

Thymosin beta 4 is associated with collateral development in coronary artery disease

Scandinavian Journal of Clinical and Laboratory Investigation (2011)

Asuman Biçer Özlem Karakurt Ramazan Akdemir Gönül Erden Ali Yıldız

Objectives: Thymosin beta 4 (Tβ4) plays an essential role in cardiac vessel development and is currently being developed as a therapeutic agent for the treatment of coronary artery disease (CAD) in some experimental studies. Thus, we aimed to investigate the association of serum Tβ4 levels and collateral formation in patients presenting with severely stenotic CAD. Methods: Thirteen patients with poor collateral development and 16 age- and sex-matched patients with good collateral development who had ≥ 95% stenosis in at least one major coronary artery on coronary angiogram (CAG) were enrolled in the study. The Gensini score was calculated for each patient by using CAG results. Collateral development was classified according to the Cohen-Rentrop method. Serum Tβ4 levels were measured with enzyme-linked immune sorbent assay. Results: There were no statistically significant differences between the two groups in regard to clinical and laboratory characteristics of the patients except for Tβ4 levels. The Tβ4 levels in the well-collateralized study group were found to be significantly higher than those of the poorly collateralized study group and serum Tβ4 levels were positively correlated with the collateral development. Conclusions: Our findings suggest that serum Tβ4 levels are significantly associated with the collateral development in severe CAD.

Collateral circulation

Thymosin

10.3109/00365513.2011.599417

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Citations (13)

Stent thrombosis: Nightmare of the interventional cardiology era

International Journal of Cardiology (2009)

Özlem Karakurt Ramazan Akdemir

Interventional cardiology

Coronary restenosis

Coronary thrombosis

10.1016/j.ijcard.2009.03.002

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Citations (3)

Letter to the Editor Stent thrombosis: Nightmare of the interventional cardiology era

Özlem Karakurt Ramazan Akdemir

Coronary stents have marked an era in the interventional cardiology and have significantly decreased the rates of acute restenosis. Although diminished rates of restenosis have been observed with stents with respect to balloon angioplasty, restenosis is still a major problem of the interventional procedures. Stent thrombosis (ST) after percutaneous coronary intervention (PCI) is a rare and usually poor prognostic event that might result in myocardial infarction (MI) and sudden death .We wanted to summarize the main features of the issue. Crown Copyright © 2009 Published by Elsevier Ireland Ltd. All rights reserved.

Interventional cardiology

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Tricuspid balloon valvuloplasty to treat tricuspid stenosis.

PubMed (2010)

Ekrem Yeter Özlem Karakurt Harun Kılıç Ramazan Akdemir Sadık Açıkel

Tricuspid stenosis

Balloon valvuloplasty

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Citations (24)