Dandan Ma

Southern Medical University

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LI Gen-you

Jiyang College of Zhejiang A&F University

Buling Wu

Southern Medical University

Xinghong Luo

Southern Medical University

Shuaimei Xu

Southern Medical University

Tingting Ning

Southern Medical University

ZHENG-HAI CHEN

Zhejiang Academy of Forestry

Chunbo Hao

Hainan Medical University

Wen‐Yuan Xie

Zhejiang Environmental Monitoring Center

Xiaoyi Zhang

University of Electronic Science and Technology of China

Jingyao Yin

Sun Yat-sen University

Cooperative Institutions

Southern Medical University

Chinese Academy of Sciences

Sun Yat-sen University

Air Force Medical University

Shanghai Jiao Tong University

Zhejiang University

Capital Medical University

Peking University

Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

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Proteomic Analysis of Mesenchymal Stem Cells from Normal and Deep Carious Dental Pulp

PLoS ONE (2014)

Dandan Ma Li Cui Jie Gao Wenjuan Yan Ying Liu

Dental pulp stem cells (DPSCs), precursor cells of odontoblasts, are ideal seed cells for tooth tissue engineering and regeneration. Our previous study has demonstrated that stem cells exist in dental pulp with deep caries and are called carious dental pulp stem cells (CDPSCs). The results indicated that CDPSCs had a higher proliferative and stronger osteogenic differentiation potential than DPSCs. However, the molecular mechanisms responsible for the biological differences between DPSCs and CDPSCs are poorly understood. The aim of this study was to define the molecular features of DPSCs and CDPSCs by comparing the proteomic profiles using two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) in combination with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Our results revealed that there were 18 protein spots differentially expressed between DPSCs and CDPSCs in a narrow pH range of 4 to 7. These differently expressed proteins are mostly involved in the regulation of cell proliferation, differentiation, cell cytoskeleton and motility. In addition, our results suggested that CDPSCs had a higher expression of antioxidative proteins that might protect CDPSCs from oxidative stress. This study explores some potential proteins responsible for the biological differences between DPSCs and CDPSCs and expands our understanding on the molecular mechanisms of mineralization of DPSCs in the formation of the dentin-pulp complex.

Dentinogenesis

10.1371/journal.pone.0097026

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Chromosomal-scale genome assembly of the Mediterranean mussel Mytilus galloprovincialis

Scientific Data (2024)

Guo-Dong Han Dandan Ma Li-Na Du Zhenjun Zhao

Abstract The Mediterranean mussel, Mytilus galloprovincialis , is a significant marine bivalve species that has ecological and economic importance. This species is robustly resilient and highly invasive. Despite the scientific and commercial interest in studying its biology and aquaculture, there remains a need for a high-quality, chromosome-scale reference genome. In this study, we have assembled a high-quality chromosome-scale reference genome for M. galloprovincialis . The total length of our reference genome is 1.41 Gb, with a scaffold N50 sequence length of 96.9 Mb. BUSCO analysis revealed a 97.5% completeness based on complete BUSCOs. Compared to the four other available M. galloprovincialis assemblies, the assembly described here is dramatically improved in both contiguity and completeness. This new reference genome will greatly contribute to a deeper understanding of the resilience and invasiveness of M. galloprovincialis .

10.1038/s41597-024-03497-5

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Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus

Biomedicine & Pharmacotherapy (2023)

Jiayu Luo Tingting Ning Xing Li Tao Jiang Shenglong Tan

Diabetes is a common metabolic disease characterized by an imbalance in blood glucose levels. The pathogenesis of diabetes involves the essential role of cytokines, particularly the IL-12 family cytokines. These cytokines, which have a similar structure, play multiple roles in regulating the immune response. Recent studies have emphasized the importance of IL-12 family cytokines in the development of both type 1 and type 2 diabetes mellitus. As a result, they hold promise as potential therapeutic targets for the treatment of these conditions. This review focuses on the potential of targeting IL-12 family cytokines for diabetes therapy based on their roles in the pathogenesis of both types of diabetes. We have summarized various therapies that target IL-12 family cytokines, including drug therapy, combination therapy, cell therapy, gene therapy, cytokine engineering therapy, and gut microbiota modulation. By analyzing the advantages and disadvantages of these therapies, we have evaluated their feasibility for clinical application and proposed possible solutions to overcome any challenges. In conclusion, targeting IL-12 family cytokines for diabetes therapy provides updated insights into their potential benefits, such as controlling inflammation, preserving islet β cells, reversing the onset of diabetes, and impeding the development of diabetic complications.

Proinflammatory cytokine

Pathogenesis

10.1016/j.biopha.2023.115958

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A newly escaped plant species in Zhejiang Province : Hypochaeris radicata

YE Xi-yang LI Gen-you Dandan Ma Wen‐Yuan Xie Wang Yue-pei

Hypochaeris radicata (Compositae)is a new record as escaped species in Zhejiang Province , which discovered in Zhejiang Forestry College in Lin' an City .Its morphological characteristics and purpose are introduced . [ Ch , 7 ref .]

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Four newly records of naturalized plant found in Zhejiang, China

Journal of Zhejiang A & F University (2012)

Miao Guo-li Chen Zheng-hai Wen‐Yuan Xie Kai Ma Dandan Ma

Four newly recorded species found in Zhejiang Province were reported. Ludwigia leptocarpa （Nutt.） H. Hara and Nuttallanthus canadensis （L.） D. A. Sutton are new recorded species of China，and Nuttallanthus is a new recorded genus of China. Verbena brasiliensis Vell. is a new recorded species of Chinese mainland，and Erechtites hieracifolia （L.） Raf. ex D C was a new recorded species of Zhejiang Province. All of the four species were naturalized.［Ch，8 ref.］

10.11833/j.issn.2095-0756.2012.03.025

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Expression difference and function research of family with sequence similarity 96, member B in human hepatocellular carcinoma

Zhonghua shiyan waike zazhi (2014)

Zhiyong Zhang Xun Cai Dandan Ma Hanjun Li Weidong Jin

Objective To study the expression difference of family with sequence similarity 96,member B (FAM96B) in human hepatocellular carcinoma (HCC) and its impact on the proliferation and apoptosis of HepG2 cell line.Methods FAM96B mRNA and protein expression was examined respectively by real-time fluorogenic quantitative polymerase chain reacton (FQ-PCR) and Western blotting in tumor tissues and adjacent tissues from 42 patients with HCC.The FAM96B mRNA and protein expression was detected in HepG2 and L-02 cells.Moreover the eukaryotic vector of human FAM96B was constructed and transfected into HepG2 cells.The proliferative rate and apoptosis rate of HepG2 cells were examined by the methyl thiazol tetrazolium (MTT) assay and fluorescence-activated cell sorting (FACS).Results In 42 patients with HCC,the global mRNA expression of FAM96B was 0.304 ± 0.094 times in tumor tissues than in adjacent tissues.And its mRNA expression was 0.406 ±0.115 times in HepG2 cell than in L-02 cell.While the Western blotting analysis confirmed that FAM96B protein expression in tumor tissues was 0.288±0.132 times lower than in the adjacent tissues (P ＜ 0.05).And FAM96B protein expression in HepG2 cell was 0.359 ± 0.143 times lower than in L-02 cell.The MTT assay showed that the A value inFAM96B group was lower than in control group,and overexpression of FAM96B significantly inhibited proliferation of HepG2 cells (P ＜0.05).FACS analysis indicated that there was significant difference in cell apoptosis rate between FAM96B-expressing clones group and the control group (vector-transfected cells group) (P ＜ 0.05).Conclusion FAM96B expression showed statistically significant difference between tumor tissues and adjacent tissues in 42 cases of HCC.Moreover FAM96B expression in HepG2 cells was significantly lower than in L-02 cells (P ＜ 0.05).Furthermore,overexpression of FAM96B can induce apoptosis of HepG2 cells and inhibit proliferation of HepG2 cells.The data suggest that FAM96B probably plays an important role in carcinogenesis of HCC. Key words: Carcinoma, hepatocellular; Family with sequence similarity 96, member B; Proliferation

Cell Sorting

10.3760/cma.j.issn.1001-9030.2014.07.034

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TLR4 Activation by Lipopolysaccharide and Streptococcus mutans Induces Differential Regulation of Proliferation and Migration in Human Dental Pulp Stem Cells

Journal of Endodontics (2014)

Ying Liu Yan Gao Xueling Zhan Li Cui Shuaimei Xu

Pulpitis

Lipoteichoic acid

10.1016/j.joen.2014.03.015

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