Timothy H. Self

University of Tennessee at Knoxville

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Christopher K. Finch

University of Tennessee Health Science Center

Elizabeth A. Tolley

University of Tennessee Health Science Center

Mark J. Rumbak

University of South Florida

Tiffany M. Kelso

University of Tennessee Health Science Center

Justin B. Usery

University of Arkansas for Medical Sciences

J. Wallace

Vanderbilt University Medical Center

Kutay Demirkan

Hacettepe University

Cary R. Chrisman

University of Tennessee Health Science Center

Nabil Abou‐Shala

King Faisal Specialist Hospital & Research Centre

Judith E. Soberman

Prevention Group

Cooperative Institutions

University of Tennessee Health Science Center

202

University of Tennessee at Knoxville

Methodist University Hospital

Regional Medical Center

Methodist Le Bonheur Healthcare

American Association of Colleges of Pharmacy

University of Florida

Johns Hopkins University

Memphis VA Medical Center

Veterans Health Administration

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Intracerebral hemorrhage secondary to a warfarin-metronidazole interaction

The American journal of geriatric pharmacotherapy (2008)

Amanda Howard-Thompson April C. Hurdle Lori B. Arnold Christopher K. Finch Christopher W. Sands

10.1016/j.amjopharm.2008.03.003

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Citations (25)

Emergency Department and Hospital Treatment of Asthma

Journal of Pharmacy Practice (1992)

Sandra J. Tsiu Timothy H. Self

Asthma is one of the most frequently treated problems in emergency departments and hospitals. Over the last 10 years, several excellent clinical trials have redefined the optimal approach to treating acute, severe asthma. Both in the emergency department and in the hospital, frequent doses of inhaled β 2 -agonists and systemic corticosteroids are the cornerstones of treatment. In either setting, theophylline therapy adds no or minimal benefits. Inhaled anticholinergics add to the efficacy of the initial dose only of inhaled β 2 -agonist in the emergency department. Pharmacists should help ensure optimal treatment in acute care settings via protocols as well as routine patient monitoring and drug use evaluation. Improving long-term prevention of asthma should also be addressed by careful patient education and treatment protocols. Serving on a case management team is one excellent approach of helping patients with asthma. Providing pharmaceutical care for asthmatics is a rewarding experience that can dramatically improve clinical outcomes, including a reduced need for emergency and hospital treatment. Copyright © 1992 by W.B. Saunders Company

Asthma management

10.1177/089719009200500404

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Citations (0)

Possible Interaction of Indomethacin and Warfarin

Drug Intelligence & Clinical Pharmacy (1978)

Timothy H. Self Mark S. Soloway Don Vaughn

A case report of a possible interaction between indomethacin and warfarin is presented. The effect of warfarin on the prothrombin time (PT) was enhanced while indomethacin was given concurrently. Substitution of Ibuprofen for indomethacin resulted in the desired control of the prothrombin time. Based on the results of controlled clinical trials and on the rarity of case reports, there is probably an extremely low incidence of enhancement of warfarin-induced hypoprothrombinemia by indomethacin.

Hypoprothrombinemia

Prothrombin time

Ibuprofen

10.1177/106002807801201001

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Citations (11)

Update on rifampin, rifabutin, and rifapentine drug interactions

Current Medical Research and Opinion (2012)

Anne M. Baciewicz Cary R. Chrisman Christopher K. Finch Timothy H. Self

Background:Rifampin is a potent inducer of both cytochrome P-450 oxidative enzymes and the P-glycoprotein transport system. Among numerous well documented, clinically significant interactions, examples include warfarin, oral contraceptives, itraconazole, digoxin, verapamil, simvastatin, and human immunodeficiency virus-related protease inhibitors. Rifabutin reduces serum concentrations of antiretroviral agents, but less so than rifampin. Rifapentine is also an inducer of drug metabolism.Methods:A literature search of English language journals from 2008 to March 2012 was completed using several databases, including PubMed, EMBASE, and SCOPUS. Search terms included rifampin, rifabutin, rifapentine AND drug interactions.Findings:Examples of clinically relevant interactions with rifampin demonstrated by recent reports include posaconazole, voriconazole, oxycodone, risperidone, mirodenafil, and ebastine.Conclusions:To avoid a reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin, rifabutin, or rifapentine are added to or discontinued from medication regimens, clinicians need to be aware of these interactions. Recent studies have indicated that other transporter systems play a role in these drug interactions. As reports of rifampin drug interactions continue to grow, this review is a reminder to clinicians to be vigilant.

Rifabutin

Rifapentine

Rifamycin

Posaconazole

Raltegravir

10.1185/03007995.2012.747952

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Citations (158)

Lower Serum Digoxin Concentrations in Heart Failure and Reassessment of Laboratory Report Forms

The American Journal of the Medical Sciences (2002)

Roya M. Sameri Timothy H. Self Christopher K. Finch Judith E. Soberman

Therapeutic index

Serum concentration

10.1097/00000441-200207000-00003

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Citations (15)

Nitrofurantoin-Induced Hepatotoxicity: A Rare Yet Serious Complication

Southern Medical Journal (2014)

Sami Sakaan Jennifer D. Twilla Justin B. Usery John C. Winton Timothy H. Self

Nitrofurantoin is a commonly prescribed antibiotic for the treatment of recurrent uncomplicated urinary tract infections. Its importance has been emphasized by the current international clinical practice guidelines for the management of uncomplicated cystitis. Since its introduction into clinical practice, nitrofurantoin has been associated with various adverse effects, including hepatotoxicity. We searched the English-language literature using PubMed and SCOPUS for the period 1961 through the end of February 2013. Key search terms included "nitrofurantoin AND hepatotoxicity" as well as "nitrofurantoin AND hepatitis." When studies or case reports were found, we assessed articles cited in those publications. A broad spectrum of liver toxicity associated with nitrofurantoin use has been reported, ranging from acute hepatitis, granulomatous reaction, cholestasis, or autoimmune-mediated hepatitis to chronic active hepatitis that could lead to cirrhosis or death. The mechanism of hepatotoxicity is poorly understood, but it is believed to be the result of an immunologic process or a direct cytotoxic reaction. It has been postulated that prolonged exposure to nitrofurantoin, female sex, advanced age, and reduced renal function increase the risk of developing hepatotoxicity. For the management of severe cases, corticosteroids have been used along with nitrofurantoin discontinuation. Because of mixed results, the utility of corticosteroids has not been proven and should be used judiciously. Given the severity and seriousness of the adverse effect of hepatotoxicity, clinicians should weigh the risks and benefits of nitrofurantoin before initiating therapy, especially in long-term prophylaxis in high-risk patients. Clinicians also should be well versed in recognizing and managing liver injury associated with nitrofurantoin.

Nitrofurantoin

Discontinuation

Toxic hepatitis

Overdiagnosis

Autoimmune Hepatitis

10.1097/smj.0000000000000059

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Citations (31)

Smoking and Asthma

The Journal of the American Board of Family Medicine (2011)

M. Stapleton Amanda Howard-Thompson Christine Marie George Robert M. Hoover Timothy H. Self

Background: The purpose of this review is to describe the current understanding of the prevalence and adverse effects of cigarette smoking and secondhand smoke (SHS) in asthmatics in terms of patient outcomes and response to inhaled corticosteroids. Methods: We searched the English biomedical literature via PubMed, Embase, and Scopus using the terms "smoking and asthma," "secondhand smoke and asthma," "environmental tobacco smoke and asthma," and "smoking/secondhand smoke and corticosteroids." We also reviewed reference lists of identified articles for relevant citations. Results: In asthmatic patients who smoke, disease control is poorer than in asthmatic nonsmokers. Of all forms of SHS, maternal exposure seems to have the largest impact on asthma by increasing the frequency and severity of the disease and decreasing lung function. Asthmatic children exposed to multiple household smokers face an increased risk for respiratory illness-related absences from school, and these effects persist during adolescence but weaken during adulthood. Airway mucosal permeability is increased in smokers, which could lead to increased clearance of inhaled corticosteroids from the airways. Smokers also have decreased histone deacetylase activity, which is necessary for corticosteroids to fully suppress cytokine production, and can lead to corticosteroid resistance. Conclusions: Cigarette smoking and SHS in asthmatics lead to detrimental effects in patient outcomes and effectiveness of steroid therapy.

Tobacco smoke

Fluticasone propionate

10.3122/jabfm.2011.03.100180

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Citations (147)

Clinical pharmacist-initiated asthma management for adult minorities: Does patient education as part of state of the art therapy affect outcomes?

Patient Education and Counseling (1994)

Timothy H. Self Tiffany M. Kelso Nabil Abou‐Shala Greta M. Heilker Kristopher L. Arheart

Affect

Asthma management

Patient Education

10.1016/0738-3991(94)90162-7

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Citations (3)

Incorrect use of peak flow meters: are you observing your patients?

Journal of Asthma (2014)

Timothy H. Self Christa M. George J. Wallace Shanise Patterson Christopher K. Finch

Monitoring peak expiratory flow (PEF) values is one option as part of asthma action plans per national guidelines. PEF assessment is also recommended in emergency department and hospitalized patients. Incorrect use of peak flow meters (PFM) has obvious implications for appropriate decisions by patients and clinicians.We searched the English literature via PubMed and SCOPUS using the following search terms: PEF maneuver; incorrect use of PFM. When pertinent articles were found, we assessed publications cited in those papers. All studies related to incorrect use of PFM in patients with asthma were included.Nine studies have reported errors in performing the PEF maneuver, including three pediatric and six adult studies. Errors were found at most steps of the maneuver, and inability to perform all steps correctly was common in these investigations. Examples of errors included failure to inhale fully or give maximum effort on exhalation, accelerating air with the tongue and buccal musculature, and performing only one attempt versus three. Gender differences in correct use of PFM are suggested by three adult studies. One study described falsifying PEF values by manipulating the PFM indicator, and another investigation assessed the PEF maneuver in two positions in bed versus the correct posture of standing.Many pediatric and adult patients do not use PFM correctly. Clinicians should regularly observe patients use PFM to detect errors and help ensure correct use and accurate PEF measurements.

Exhalation

Peak flow meter

10.3109/02770903.2014.914218

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Citations (14)

Pitfalls In Prescribing: Metronidazole Dosing in Patients With Hepatic Dysfunction

Quinn Czosnowski PharmD Lauren M. Czosnowski J. Ashley Taylor Timothy H. Self

Metronidazole, the prototype nitroimidazole, was originally released in 1959 for the treatment of Trichomonas vaginalis infections. It has since been used to treat a variety of infections caused by anaerobic and facultative anaerobic bacteria and protozoa. Here we discuss the need for dosing adjustments in patients with hepatic disease.

Nitroimidazole

Trichomonas

Facultative

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