Mohammad Farahbakhsh

Shahid Beheshti University of Medical Sciences

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Mahmood Nabavi

Imam Hossein Hospital

‪D

‪Simin Dokht Shoaei

Imam Hossein Hospital

Mehrdad Haghighi

Shahid Beheshti University of Medical Sciences

Rama Bozorgmehr

Shahid Beheshti University of Medical Sciences

Nazanin Rahnama

Shahid Beheshti University of Medical Sciences

Ahmad Ameri

Shahid Beheshti University of Medical Sciences

Latif Gachkar

Shahid Beheshti University of Medical Sciences

Hossein Izadi

Shahid Beheshti University of Medical Sciences

Hadiseh Shabanpour Dehbaneh

Shahid Beheshti University of Medical Sciences

Fahimeh Hadavand

Shahid Beheshti University of Medical Sciences

Cooperative Institutions

Lagos State Health Service Commission

106

Ekiti State University

102

Ospedale di Macerata

100

University of Macerata

Brunel University of London

Network Group (Czechia)

Shahid Beheshti University of Medical Sciences

Imam Hossein Hospital

Shahid Beheshti University

Istituti di Ricovero e Cura a Carattere Scientifico

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Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: Short Course Results

Research Square (Research Square) (2020)

Ahmad Ameri Nazanin Rahnama Rama Bozorgmehr Majid Mokhtari Mohammad Farahbakhsh

Abstract Objectives: The COVID-19 outbreak is affecting people worldwide. Most of the infected patients suffering from respiratory involvement that may progress to acute respiratory distress syndrome. This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiotherapy in patients with COVID-19 pneumonia. Methods: In this clinical trial, done in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen for their documented pneumonia. Participants were treated with whole-lung irradiation in a single fraction of 0.5 Gy plus national protocol for the management of COVID-19. Vital signs (including blood oxygenation and body temperature) and laboratory findings (IL-6 and CRP) were recorded before and after irradiation. Results: Between 21 May 2020 and 24 June 2020, five patients received whole-lung irradiation. They followed for 5-7 days to evaluate response to treatment and toxicities. The clinical and paraclinical findings of four patients (except for patient #4 that get worst and died on day 3) improved on the first day of irradiation. Patient #3 opted-out the trial on the third day of irradiation. The mean time to discharge was 6 days for the other three patients. No acute radiation-induced toxicity was recorded. Conclusion: With a response rate of 80%, whole-lung irradiation in a single fraction of 0.5 Gy had encouraging results in oxygen-dependent patients with COVID-19 pneumonia.

Pneumonitis

10.21203/rs.3.rs-40507/v1

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Citations (8)

Study on the Efficiency of a Multi-layer Perceptron Neural Network Based on the Number of Hidden Layers and Nodes for Diagnosing Coronary- Artery Disease

Jentashapir Journal of Health Research (2017)

Hamid Moghaddasi Bahareh Ahmadzadeh Reza Rabiei Mohammad Farahbakhsh

Background: Through the diagnostic decision support systems, potential patients or those who are on the threshold succumbing to a disease can be diagnosed early; thus, the prevention of unnecessary angiography for people not suffering from the coronary-artery disease as well as its dangers and costs can be avoided. The present study aimed at the efficiency evaluation of a multilayer perceptron neural network based on the number of hidden layers and nodes to diagnose coronary heart disease. Methods: A fundamental analysis was conducted on the provided data related to 13,228 patients who had undergone coronary angiography and the database (nine risk factors including age, gender, BMI, body fat, family history, smoking, blood cholesterol, diabetes, and high blood pressure) was investigated in this research using SPSS statistics (17.0) and R (2.13.2) software. In the next stage, through utilizing MATLAB (R2014a), 1332 different MLP neural networks were created. Results: Based on the largest area under the ROC curve, the best model of MLP neural network was selected involving two hidden layers; the first layer had 34 and the second one had 18 hidden nodes. This model had the highest efficiency of 82% in the diagnosis of coronary artery disease. Conclusions: The obtained results demonstrated that the MLP makes an acceptable approach to the diagnosis of coronary artery disease in patients without the need for performing angiography. The development of this model will result in creating an algorithm for decision support systems to diagnose coronary artery disease, as well.

Multilayer perceptron

Perceptron

10.5812/jjhr.63032

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Citations (5)

Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results

International Journal of Radiation Oncology*Biology*Physics (2020)

Ahmad Ameri Nazanin Rahnama Rama Bozorgmehr Majid Mokhtari Mohammad Farahbakhsh

Pneumonitis

10.1016/j.ijrobp.2020.07.026

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Citations (69)

Twin pregnant woman with COVID-19: a case report

DOAJ (DOAJ: Directory of Open Access Journals) (2020)

Seyedpouzhia Shojaei Mehran Kouchek Mir Mohammad Miri Sara Salarian Mohammad Sistanizad

A Case of pregnant woman (G2Ab1, twin pregnancy with microinjection, Gestational Age 23 weeks and 3 days) referred to our center with a complaints of fever and dry cough and dyspnea. She was admitted with a diagnosis of COVID-19. During the hospitalization, O2 saturation progressively decreased, which led to patient get intubate. Gradual recovery with treatment occurred and the patient was extubed. Unfortunately, she was intubated again due to decreased O2 saturation, 5 days later. Liver enzymes increased, then both fetuses died intrauterine, the cardiac output then declined to 10% and the mother died within hours.

2019-20 coronavirus outbreak

Twin Pregnancy

Conjoined twins

10.22037/jcma.v5i1.29688

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Citations (9)

Neurological features and outcome in COVID-19: dementia can predict severe disease

Journal of NeuroVirology (2021)

Mehran Ghaffari Hossein Ansari Nahid Beladimoghadam Seyed Hossein Aghamiri Mehrdad Haghighi

The COVID-19 pandemic has infected more than 22 million people worldwide. Although much has been learned about COVID-19, we do not know much about its neurological features and their outcome. This observational study was conducted on the patients of Imam Hossein Hospital, and 361 adult patients (214 males) with confirmed diagnosis of COVID-19 from March 5, 2020 to April 3, 2020, were enrolled. Data was gathered on age, sex, comorbidities, initial symptoms, symptoms during the disease course, neurological symptoms, and outcome. The mean age of the patients was 61.90 ± 16.76 years. The most common initial symptoms were cough, fever, and dyspnea. In 21 patients (5.8%), the initial symptom was neurological. History of dementia was associated with severe COVID-19 disease (odds ratio = 1.28). During the course of the disease, 186 patients (51.52%) had at least one neurological symptom, the most common being headache (109 [30.2%]), followed by anosmia/ageusia (69, [19.1%]), and dizziness (54, [15%]). Also, 31 patients had neurological complications (8.58%). Anosmia, ageusia, dizziness, and headache were associated with favorable outcome (P < 0.001), while altered mental status and hemiparesis were associated with poor outcome. The mortality rate of patients who had neurological complications was more than twice than that of patients without neurological complication (P = 0.008). Almost half of the patients experienced at least one neurological symptom, which may be the initial presentation of COVID-19. Dementia appears to be associated with severe COVID-19. Mortality was higher in patients with neurological complications, and these patients needed more intensive care.

Anosmia

Neurological examination

10.1007/s13365-020-00918-0

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Citations (32)

Investigating relationship of talent management and organizational entrepreneurship

International journal of life sciences & earth sciences (2019)

Fereydoon Azma Mohammad Farahbakhsh Reza Safarzad Ehsan Farahnaki

Introduction: talent management is a comprehensive strategy and an approach to international human resource practices and a commitment to widespread sharing of the belief that human resource is a priority and a source of competitive advantage. Talent management ensures the organizations that competent individuals with the right skills have taken the right position. The aim of this study was to investigate the relationship between talent management and organizational entrepreneurship. Methodology: The present study is an applied one in terms of its nature and purpose, and it is a descriptive and correlational one in terms of the data collection method to test the hypothesis. The population of this study included experts, officials, supervisors and middle and top managers of Golestan province Gas Company who have at least 7 years’ experience. Accordingly, a total number of 51 participated in the study. A questionnaire was used to collect data. Data analysis was carried out through SPSS software for descriptive data and SMART PLS software for inferential data. Results: This study shows that there is a significant positive relationship between talent management and organizational entrepreneurship, and components of each of the main criteria also have a significant relationship with each other. Conclusion: The findings suggest that managers should improve their organization's talent management system in order to increase innovation and competitiveness. These systems can complete and implement various initiatives by creating opportunities to achieve talent resources and providing transparency in selection criteria.

Talent Management

Statistical population

Middle management

10.31295/ijle.v2n1.76

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Citations (4)

Amikacin liposome and Mycobacterium avium complex: A systematic review

PLoS ONE (2022)

Moein Zangiabadian Donya Malekshahian Erfan Arabpour Sahel Shafiee Dolat Abadi Fartous Yazarlou

The prevalence of Mycobacterium avium complex (MAC) is increasing globally. Macrolide-based multidrug regimens have been recommended as the first-line treatment for patients with MAC pulmonary disease. However, developing macrolide resistance was associated with poor treatment outcomes and increased mortality. In 2018, the U.S. Food and Drug Administration approved liposomal amikacin for inhalation (LAI) to treat refractory MAC pulmonary disease. The current systematic review aimed to evaluate LAI's outcomes and adverse events in MAC pulmonary disease.The systematic search was performed in PubMed/Medline, EMBASE, and the Cochrane Controlled Register of Trials (CENTRAL) up to March 8, 2022. The search terms included Mycobacterium avium complex, MAC, amikacin, and liposomal amikacin.After reviewing 1284 records, four papers met the inclusion criteria, including three clinical trials and one prospective cohort study. These studies showed that adding LAI to guideline-based therapies can increase sputum culture conversion rate and achieve early sustained (negative sputum culture results for 12 months with treatment) and durable (negative sputum culture results for three months after treatment) negative sputum culture. In addition, extended LAI use was a potential benefit in patients considered refractory to initial treatment. The most prevalent treatment-emergent adverse events (TEAE) reported in the LAI group were the respiratory TEAE.LAI could increase the sputum culture conversion rate and achieve early sustainable, durable negative sputum culture. However, additional large-scale research is required to confirm the results.

Sputum culture

Amikacin

Culture conversion

10.1371/journal.pone.0279714

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Citations (2)

Evaluation Of tuberculin skin test and booster effect in hemodialysis patients

Archives of Clinical Infectious Diseases (2006)

Masomeh Alimagham Saied Aminiafshar Latif Gachkar Kamran Sharafim Mohammad Farahbakhsh

Background : Tuberculosis is an endemic disease in Iran which may occur more frequently among hemodialysis patients. We have evaluated tuberculin skin test (TST) in hemodialysis patients in a university hospital in 2003-2004. Materials and methods : Sixty-seven hemodialyis patients were enrolled for tuberculin skin tests. Indurations were measured 48-72 hours after the injection and then on the 7th day. Those with indurations less than 5mm in TST1 were introduced for TST2. Results : Of 67 patients, 18(26.9%) had indurations of less than 5mm in TST1 and were introduce for TST2 among whom 7 (39%) had an induration measured less than 5mm. Of 18 cases, 11 (61%) were revealed to have booster effect that represent a ratio of 16% of all studied hemodialysis patients in our study. Conclusion : It seems that the second TST is a better indicator of infectivity in hemodialysis patients, especially for patients who require repeated or annual estimation for M. tuberculosis infection. Keywords : Hemodialysis, Booster effect, Tuberculosis, Tuberculin skin test.

Booster (rocketry)

Skin test

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Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

World Journal of Emergency Surgery (2023)

Massimo Sartelli Philip S. Barie Federico Coccolini Mohamed Abbas Lilian M. Abbo

Abstract Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or “golden rules,” for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.

10.1186/s13017-023-00518-3

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Citations (35)

Think about Neurobrucellosis, When a Man Cries

International journal of molecular and clinical microbiology (2015)

Mohammad Farahbakhsh Laleh Alizadeh Zahra Arab‐Mazar Mehrdad Haghighi ‪Simin Dokht Shoaei

Neurobrucellosis (N.B) is a rare and severe form of systemic Brucella infection. We introduced an unusual case that “Psychologic Symptoms” was the most prominent complaints of his family. He was a 50-year-old man who has worked in butchery. His problems had begun 2 months prior to his admission with mood disorders, arthralgia, weakness, headache, and night sweats; he has recurrent crying with no obvious environmental problem! Wright agglutination test, Coomb’s Wright and 2ME were negative 2 times in outpatient work-ups and the other lab tests weren’t useful in diagnosis. Treatment trials for acute sinusitis and aseptic meningitis have had some improvements of symptoms but his clinical condition was not acceptable. A brain MRI was performed; results indicated few T2W hypersignal points of white matter specially periventricular. Brucellosis serologic tests were requested “for third time” and the results were positive.The patient has treated with cotrimoxazole, doxycycline, and rifampicin for 6 months. Two weeks after this treatment, all of mentioned symptoms subsided. The brain MRI 6 weeks after treatment was repeated, and the previously seen lesions had improved. The lumber puncture 3 months after treatment was repeated and results were normal. Conclusion: It can be concluded that when a patient in an endemic area suffers from chronic mood disorders, headache, fever, and other non-specific manifestations that cannot be explained by other etiologies; it may be a case of NB. In this case, the “repeated” Wright test and excellent response to NB treatment confirmed the diagnosis.

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