Satish Chandrasekhar Nair

Apollo Hospitals

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Halah Ibrahim

Khalifa University of Science and Technology

Jayadevan Sreedharan

Gulf Medical University

K.R. Panikkar

Jawaharlal Nehru Tropical Botanic Garden and Research Institute

Karthyayani Priya Satish

Kasturba Medical College, Mangalore

Thana Harhara

Shaikh Khalifa Medical City

David F. Smith

Emory University

Mahera Abdulrahman

Mohammed Bin Rashid University of Medicine and Health Sciences

Ronald A. Rimerman

University of Nebraska Medical Center

Ashwini Tayade

Datta Meghe Institute of Medical Sciences

Nandini Sethuraman

Apollo Hospitals

Cooperative Institutions

Tawam Hospital

United Arab Emirates University

University of Nebraska Medical Center

Shaikh Khalifa Medical City

Al Ain Hospital

Post Graduate Institute of Medical Education and Research

Johns Hopkins University

Apollo Hospitals

Gulf Medical University

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Acute presentation of Leriche syndrome in United Arab Emirates: A case report

Case Reports International (2014)

Omar Sherif Askar Abdel Noureldin Satish Chandrasekhar Nair

Introduction: Aortoiliac occlusive disease or Leriche syndrome is a serious condition in which patients usually present with the triad of chronic symptoms consisting of claudication of the buttocks and thighs, absent or decreased femoral pulses, and impotence. Our report, first from the gulf region, describes an acute severe presentation of Leriche syndrome which resulted in mortality. This case report helps emergency room physicians in the diagnosis and management of acute presentation of aortoiliac occlusive disease, especially in international settings. Case Report: A 32-year-old male presented to our emergency department as a referral from another hospital. He complained of severe back pain and bilateral leg weakness. The patient had two cardiac arrests, first one was in the operating room and died after the second arrest two days later in ICU. Conclusion: It is critical that the examining physician place aortoiliac occlusive disease high on the differential during patient assessment, given that the rapidity of diagnosis and further management has significant impact on morbidity and mortality.

Presentation (obstetrics)

10.5348/crint-2014-4-cr-2

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Citations (1)

Pediatric Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection – UAE

Journal of Infection and Public Health (2020)

Faiza Al Kindi Satish Chandrasekhar Nair Rayhan Hashmey

2019-20 coronavirus outbreak

Coronavirus Infections

Betacoronavirus

Coronavirus

10.1016/j.jiph.2020.01.181

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INHIBITORY EFFECTS OF NIGELLA SATIVA AND CROCUS SATIVA ON CHEMICAL CARCINOGENESIS IN MICE

M.J. Salomi Satish Chandrasekhar Nair K.R. Panikkar

Nigella sativa

Crocus

Cannabis sativa

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Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity

Cancer Letters (1991)

Satish Chandrasekhar Nair Beena Panikkar Krishnacharya G. Akamanchi K.R. Panikkar

Croton oil

Anticarcinogen

Ehrlich ascites carcinoma

10.1016/0304-3835(91)90121-w

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Citations (32)

Research Letter - Effect of cyclophosphamide pretreatment on hematological indices of Indian Bonnet monkeys

M. Daisy Mythili Satish Chandrasekhar Nair S. Gunasekaran

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Protective Effects of Crocetin on the Bladder Toxicity Induced by Cyclophosphamide

Cancer Biotherapy (1993)

Satish Chandrasekhar Nair K.R. Panikkar R.K. Parthod

Cyclophosphamide (CX) has been widely used as an anticancer agent, however obtaining a maximum therapeutic potential for CX has remained a challenge, for generating undesired toxic side effects to the bladder. Crocetin, a natural carotenoid has been employed in the present studies to ameliorate the bladder toxicity of CX. Interestingly, crocetin at a dose of 50 mg/Kg modulated the release of chloroacteldehyde, a urotoxic metabolite of CX in the urine of mice given combined treatment. Crocetin at the same dose significantly elevated Glutathione-S-Transferase enzyme activity both in the bladder and the liver of mice treated with CX. The exact mechanism of the protective effect of crocetin is not known, presumable it may act as an antioxidant, trapping and scavenging free radicals during the detoxification process. In Sarcoma-180 tumor bearing mice, crocetin has the ability to protect against CX induced bladder toxicity without altering its antitumor activity. Our studies are important to identify antioxidant rescue agents to overcome dose-limiting toxicity of CX.

Crocetin

10.1089/cbr.1993.8.339

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Simulation-based Uptraining Improves Provider Comfort in the Management of Critically Ill Patients With Covid-19

Circulation (2020)

Joseph Horowitz Eugene Yuriditsky Satish Chandrasekhar Nair Bella Kaufman

2019-20 coronavirus outbreak

Coronavirus Infections

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Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein.

Molecular Endocrinology (1996)

Viravan Prapapanich S Chen Satish Chandrasekhar Nair Ronald A. Rimerman David F. Smith

A 48-kDa protein (p48) that transiently associates with progesterone receptor during cell-free assembly in rabbit reticulocyte lysate was isolated by two-dimensional gel separation. Tryptic peptide sequences were generated and used to develop an antipeptide antiserum recognizing p48 by Western immunostaining, and this antiserum was used to monitor purification of native p48 from reticulocyte lysate. Eight mouse monoclonal antibodies capable of immunoprecipitating vertebrate p48 were generated. These monoclonal antibodies served as probes to clone ten p48 cDNAs from a HeLa cDNA expression library. One of the cloned cDNAs was sequenced in its entirety and codes for a 369-amino acid protein (calculated Mr = 41,324). Northern blot analysis of RNA from multiple human tissues suggest that p48 may be ubiquitously expressed. Expression of human p48 cDNA in vitro yielded a product that comigrated with rabbit p48 by SDS-PAGE and associated with progesterone receptor in a similar manner. Immunoprecipitation of p48 complexes revealed a common association of p48 with hsp70 and, to a lesser extent, with hsp90 and p60. Thus, it appears that p48 is a novel component of the cytoplasmic molecular chaperone machinery.

Immunoprecipitation

Reticulocyte

10.1210/mend.10.4.8721986

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Citations (109)

The Development of a Clinical Research Model Complementing Medical Residency and the Assessment of Research Productivity

Cureus (2023)

Satish Chandrasekhar Nair Khaled M. Aldahmani

Despite modern healthcare infrastructure, there is a paucity of information about the clinical research framework supporting healthcare in the United Arab Emirates (UAE). Therefore, this study aimed to assess research performance productivity, and the clinical research framework, complementing medical residency, at the nation's hub for clinical research.

Harmonization

Clinical Research

10.7759/cureus.48684

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International Residency Program Directors on Implementing Educational Transformation: A Qualitative Study of Their Experiences and Strategies for Overcoming Challenges

Journal of Graduate Medical Education (2021)

Debalina Dutta Halah Ibrahim Dora J. Stadler Joseph Cofrancesco Satish Chandrasekhar Nair

ABSTRACT Background Residency program directors (PDs) need to navigate diverse roles and responsibilities as clinical teachers, administrators, and drivers of educational improvement. Little is known about the experience of PDs leading transformation of international residency programs. Objective We explored the lived experiences of international residency PDs and developed an understanding of how PDs manage educational program transformation. Methods Using a phenomenological approach, semi-structured interviews were conducted with current and former PDs involved in the transformation to competency-based medical education in the first international settings to be accredited by the Accreditation Council for Graduate Medical Education-International (ACGME-I). Thirty-three interviews with PDs from Qatar, Singapore, and the United Arab Emirates were conducted from September 2018 to July 2019, audio-recorded, and transcribed. Data were independently coded by 2 researchers. A thematic analysis was conducted and patterns that reflected coping and managing educational reform were identified. Results PDs described distinctive patterns of navigating the educational transformation. Five themes emerged: PDs (1) embraced continuous learning and self-development; (2) managed change in the context of their local settings; (3) anticipated problems and built support networks to effectively problem-solve; (4) maintained relationships with stakeholders for meaningful and constructive interactions; and (5) focused on intrinsic qualities that helped them navigate challenges. Conclusions International PDs were presented with significant challenges in implementing educational transformation but coped successfully through distinctive patterns and methods.

10.4300/jgme-d-21-00050.1

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Citations (5)