Tao-Hsin Chang

Centre for Human Genetics

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Fu-Lien Hsieh

Johns Hopkins University

Tzu‐Ping Ko

Institute of Biological Chemistry, Academia Sinica

Eric Oldfield

University of Illinois Urbana-Champaign

Po‐Huang Liang

Institute of Biological Chemistry, Academia Sinica

W.Y. Jeng

National Cheng Kung University

Rui Guo

University of Pennsylvania

Andrew H.‐J. Wang

Taipei Medical University

Jeremy Nathans

Johns Hopkins University

M.P. Hudock

University of Illinois Urbana-Champaign

E. Yvonne Jones

Centre for Human Genetics

Cooperative Institutions

National Taiwan University

Institute of Biological Chemistry, Academia Sinica

University of Oxford

Centre for Human Genetics

Johns Hopkins University

National Yang Ming Chiao Tung University

University of Illinois Urbana-Champaign

Academia Sinica

Howard Hughes Medical Institute

Johns Hopkins Medicine

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Notum deacylates Wnt proteins to suppress signalling activity

Nature (2015)

Satoshi Kakugawa Paul F. Langton M. Zebisch Steven Howell Tao-Hsin Chang

10.1038/nature14259

Cite

Citations (396)

Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes.

Journal of Clinical Investigation (1996)

S L Tsai M H Chen Chau‐Ting Yeh Chia‐Ming Chu Aung Lin

In vitro studies in patients with hepatitis B virus (HBV) infection have suggested that hepatocytolysis induced by CD8+ cytotoxic T lymphocytes (CTLs) is the most important effector pathway in eliminating infected cells. The recognition is implicated in the endogenously processed HBV antigens in the context of HLA class I molecules presented on the liver cell membrane. However, the naturally occurring HBV peptide antigens have not yet been demonstrated. We report here that a naturally processed peptide antigen P2 was isolated from HLA class I molecules of HBV-infected liver cell membrane. The P2 peptide exhibited the activity of sensitizing target cells for lysis by CD8+ CTLs. The P2 sequence (YVNVNMGLK) purified from liver tissue was in concordance with that encoded by the viral genome for the HBV nucleocapsid antigen or HBcAg 88-96. P2 peptide could also be isolated from the EBV-transformed B cells that were transfected by HBcAg-expressing vector. The P2 epitope, sharing the HLA-A11 binding motifs, was recognized by HLA-A11-restricted CD8+ CTLs. The data provided direct evidence that, in hepatitis B patients, antigenic peptides of HBV were processed by hepatocytes, presented with the class I MHC molecules, and recognized by CD8+ CTLs.

HBcAg

10.1172/jci118450

Cite

Citations (76)

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GPP

Rui Guo T.P. Ko C.K.-M. Chen W.Y. Jeng Tao-Hsin Chang

Geranylgeranyl pyrophosphate

10.2210/pdb2e8x/pdb

Cite

Citations (0)

Spectral shaping of the biphoton state from multiplexed thermal atomic ensembles

APS Division of Atomic, Molecular and Optical Physics Meeting Abstracts (2019)

Tao-Hsin Chang Guin-Dar Lin H. H. Jen

We theoretically investigate the spectral property of a biphoton state from multiplexed thermal atomic ensembles. This biphoton state originates from the cascade emissions, which can be generated by two weak pump fields under four-wave mixing condition. Under this condition, a signal photon from the upper transition, chosen in a telecommunication bandwidth, can be generated along with a correlated idler photon from the lower infrared transition. We can spectrally shape the biphoton state by multiplexing the atomic ensembles with frequency-shifted emissions, where the entropy of entanglement can be analyzed via Schmidt decompositions. We find that this spectral entanglement increases when more vapor cells are multiplexed with correlated or anti-correlated signal and idler fields. The eigenvalues in Schmidt bases approach degenerate under this multiplexing scheme, and corresponding Schmidt numbers can be larger than the number of the multiplexed vapor cells, showing the enlarged entropy of entanglement and excess correlated modes in continuous frequency spaces. We also investigate the lowest entropy of entanglement allowed in the multiplexing scheme, which is preferential for generating a pure single photon source. This shows the potentiality to spectrally shape the biphoton source, where high-capacity spectral modes can be applied in long-distance quantum communication and multimode quantum information processing.

Four-wave mixing

Source

Cite

Citations (0)

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

eLife (2015)

Tao-Hsin Chang Fu-Lien Hsieh M. Zebisch Karl Harlos Jonathan Elegheert

Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although unrelated to Wnt, Norrin activates the Wnt/β-catenin pathway. Signal complex formation involves Frizzled4 (Fz4), low-density lipoprotein receptor related protein 5/6 (Lrp5/6), Tetraspanin-12 and glycosaminoglycans (GAGs). Here, we report crystallographic and small-angle X-ray scattering analyses of Norrin in complex with Fz4 cysteine-rich domain (Fz4CRD), of this complex bound with GAG analogues, and of unliganded Norrin and Fz4CRD. Our structural, biophysical and cellular data, map Fz4 and putative Lrp5/6 binding sites to distinct patches on Norrin, and reveal a GAG binding site spanning Norrin and Fz4CRD. These results explain numerous disease-associated mutations. Comparison with the Xenopus Wnt8–mouse Fz8CRD complex reveals Norrin mimics Wnt for Frizzled recognition. The production and characterization of wild-type and mutant Norrins reported here open new avenues for the development of therapeutics to combat abnormal Norrin/Wnt signalling.

LRP5

10.7554/elife.06554

Cite

Citations (112)

Structure of Vaccinia virus A27

Tao-Hsin Chang Tzu‐Ping Ko Fu-Lien Hsieh A.H.J. Wang

10.2210/pdb3vop/pdb

Cite

Citations (0)

Identification of a putative amidase gene in yeastSaccharomyces cerevisiae

Nucleic Acids Research (1990)

Tao-Hsin Chang John Abelson

Journal Article Identification of a putative amidase gene in yeast Saccharomyces cerevisiae Get access T.-H. Chang, T.-H. Chang Division of Biology, 147-75, California Institute of Technology, Pasadena, CA 91125, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Abelson J. Abelson Division of Biology, 147-75, California Institute of Technology, Pasadena, CA 91125, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 23, 1 December 1990, Page 7180, https://doi.org/10.1093/nar/18.23.7180 Published: 01 January 1990 Article history Published: 01 January 1990 Received: 15 October 1990

Identification

Gene technology

Amidase

10.1093/nar/18.23.7180

Cite

Citations (18)

High-fidelity Rydberg controlled-Z gates with optimal pulses

arXiv (Cornell University) (2023)

Tao-Hsin Chang Tzyy-Ing Wang H. H. Jen Ying-Cheng Chen

High-fidelity control-$Z$ ($C_Z$) gates are essential and mandatory to build a large-scale quantum computer. In neutral atoms, the strong dipole-dipole interactions between their Rydberg states make them one of the pioneering platforms to implement $C_Z$ gates. Here we numerically investigate the time-optimal pulses to generate a high-fidelity Rydberg $C_{Z}$ gate in a three-level ladder-type atomic system. By tuning the temporal shapes of Gaussian or segmented pulses, the populations on the intermediate excited states are shown to be suppressed within the symmetric gate operation protocol, which leads to a $C_{Z}$ gate with a high Bell fidelity up to $99.92\%$. These optimized pulses are robust to thermal fluctuations and the excitation field variations. Our results promise a high-fidelity and fast gate operation under amenable and controllable experimental parameters, which goes beyond the adiabatic operation regime under a finite Blockade strength.

High fidelity

10.48550/arxiv.2303.16395

Cite

Citations (2)

Enhanced Specificity of Mint Geranyl Pyrophosphate Synthase by Modifying the R-Loop Interactions

Journal of Molecular Biology (2010)

Fu-Lien Hsieh Tao-Hsin Chang Tzu‐Ping Ko Andrew H.‐J. Wang

Heterotetramer

Geranylgeranyl pyrophosphate

Farnesyl pyrophosphate

10.1016/j.jmb.2010.10.011

Cite

Citations (4)

Spectrally entangled biphoton state of cascade emissions from a Doppler-broadened atomic ensemble

Journal of Physics B Atomic Molecular and Optical Physics (2019)

Tao-Hsin Chang Guin-Dar Lin H. H. Jen

We theoretically investigate the spectral property of biphoton state from the cascade emissions from a Doppler-broadened atomic ensemble. This biphoton state is spontaneously created in the four-wave-mixing process. The upper transition of the emissions lies in telecom bandwidth, which prevails in fiber-based quantum communication for low-loss transmission. We obtain the spectral property in terms of superradiant decay rates of the lower transition, excitation pulse durations, and temperature of the medium. We quantify their frequency entanglement by Schmidt decomposition and find that more entangled source can be generated with longer excitation pulses, enhanced decay rates, and significant Doppler broadening. A minimally entangled biphoton source can also be located at some optimal temperature of the atoms. This allows spectral shaping of continuous frequency entanglement, which is useful in multimode long-distance quantum communication.

10.1088/1361-6455/ab1303

Cite

Citations (2)