Simona Quattrone

University of Reggio Calabria

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Domenico Giordano

Azienda Ospedaliera Sant'Andrea

A. Di Benedetto

Azienda Ospedaliera Universitaria Policlinico "G. Martino"

Rosario D’Anna

University of Messina

Francesco Corrado

Humanitas University

Angelo Santamaria

University of Messina

Basilio Pintaudi

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

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University of Messina

University of Modena and Reggio Emilia

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Azienda Ospedaliera Universitaria Policlinico "G. Martino"

Istituto Ortopedico Gaetano Pini

Tescan (Czechia)

United States Congress

European Gravitational Observatory

Azienda Ospedaliera Sant'Andrea

Sapienza University of Rome

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Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome

Menopause The Journal of The North American Menopause Society (2010)

Domenico Giordano Francesco Corrado Angelo Santamaria Simona Quattrone Basilio Pintaudi

The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women.Eighty postmenopausal women affected by the metabolic syndrome were enrolled prospectively in the study and treated with diet plus supplementation of myo-inositol (2 g BID plus diet: intervention group) or with diet plus placebo (control group) for 6 months. They were evaluated at baseline and after 6 months for insulin resistance (homeostasis model assessment ratio [HOMA] insulin resistance), lipid profile, and blood pressure.Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown.Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women.

10.1097/gme.0b013e3181e8e1b1

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