Vaishali Londhe

Narsee Monjee Institute of Management Studies

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Rupali S. Bhadale

Narsee Monjee Institute of Management Studies

Madhura Rajadhyaksha

Narsee Monjee Institute of Management Studies

Suraj Bamankar

Narsee Monjee Institute of Management Studies

Kalyani Barve

Narsee Monjee Institute of Management Studies

Forum Jalundhwala

Narsee Monjee Institute of Management Studies

Atul P. Sherje

Shri Vile Parle Kelavani Mandal

Shailesh Kulkarni

Narsee Monjee Institute of Management Studies

Mangal S. Nagarsenker

Bombay College of Pharmacy

Nancy Pandita

Narsee Monjee Institute of Management Studies

Amrita Bajaj

Shri Vile Parle Kelavani Mandal

Cooperative Institutions

Narsee Monjee Institute of Management Studies

Shri Vile Parle Kelavani Mandal

Indian Institute of Technology Bombay

Rede de Química e Tecnologia

Chandigarh University

Banaras Hindu University

University of Nigeria

Hindu College of Pharmacy

Polytechnic Institute of Porto

Universidade Federal de Ouro Preto

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Inclusion Complex of Iloperidone with Sulfobutyl Ether Beta-Cyclodextrin: Characterization and Dissolution Studies

Rupali Sanjay Bhadale Vaishali Londhe

Iloperidone (ILO) is a second-generation antipsychotic drug and a first-line treatment approved by USFDA in May 2009. Iloperidone belongs to Biopharmaceutical Classification Systems (BCS) class II; thus, it is poorly water-soluble, highly permeable, and has pH-dependent solubility. Cyclodextrins and their derivatives have a wide range of applications in different formulations due to their complexation ability, which improves the solubility, stability, safety, and bioavailability of a drug. We have tried the complexation of iloperidone with sulfobutyl ether-β-cyclodextrin (SEβCD) to improve its solubility and dissolution. Complexation was done by the kneading method. The characterization of the SEβCD complexes with Iloperidone was done by FTIR, differential scanning calorimetry (DSC), saturation solubility, etc. A multimedia dissolution of the complex was carried out and compared with the plain drug. A significant improvement in drug release was found from SEβCD complexes in all media when compared with the drug alone.

Biopharmaceutical

Beta-Cyclodextrins

10.20944/preprints202103.0387.v1

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Formulation development and evaluation of fast dissolving film of telmisartan.

PubMed (2012)

Vaishali Londhe Kashmira B Umalkar

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.

Telmisartan

Folding endurance

Polyvinyl Alcohol

10.4103/0250-474x.10384

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NOVEL ORAL DELIVERY OF IBUPROFEN SOLUTION IN HARD GELATIN CAPSULES

International Journal of Pharmacy and Pharmaceutical Sciences (2019)

Forum Jalundhwala Vaishali Londhe Jnanadeva Bhat Surya N. Singh

Objective: The primary objective of the project was to formulate and evaluate hard capsule containing the solution of ibuprofen. It also included enhancement of solubility of ibuprofen in hydrophilic solvents to obtain a unit dose capsule acceptable for human consumption. Methods: Solution of ibuprofen was developed by the salt formation of partial drug using potassium hydroxide in PEG 600 and water. The solution was encapsulated in hard capsules with band sealing. The final formulation was evaluated for uniformity of weight, disintegration, drug content and stability. The dissolution profile was compared with that of available marketed tablets and softgels. Results: The capsules were evaluated and found compliant as per specifications mentioned in general monograph of capsules in IP 2014. The uniformity of weight of the batch of capsules was found to be 734.8 mg (±0.58). The disintegration time of these capsules was observed to be 4.45 min. The drug content was found to be 100.03% and the product is stable over three months of test period under room temperature as well as accelerated conditions. The dissolution profile showed that softgels take longer time to release the drug whereas marketed tablets showed a dissolution profile comparable with that of formulated capsules. Conclusion: The developed capsule is a unit dose of liquid containing solubilized ibuprofen delivering the drug directly into the gastrointestinal tract (GIT). These are newer solid oral dosage forms with higher patient compliance and ease in manufacturing. They require lesser steps and manufacturing area when compared to the manufacturing of compressed tablets.

Ibuprofen

Capsule

10.22159/ijpps.2019v11i6.32659

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Unlocking relief: formulation, characterization, and in vivo assessment of salicylic acid–loaded microemulgel for psoriasis management

Naunyn-Schmiedeberg s Archives of Pharmacology (2024)

Viswanath Baboy Lotlikar Sanjay Sharma Vaishali Londhe

Characterization

10.1007/s00210-024-03447-3

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Widespread applications of host-guest interactive cyclodextrin functionalized polymer nanocomposites: Its meta-analysis and review

Carbohydrate Polymers (2020)

Pooja R. Bakshi Vaishali Londhe

Thermal Stability

Hydrophobe

Polymer nanocomposite

Surface Modification

10.1016/j.carbpol.2020.116430

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Citations (27)

Exosome as a Natural Gene Delivery Vector for Cancer Treatment

Current Cancer Drug Targets (2020)

Prasad Pofali Adrita Mondal Vaishali Londhe

Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size 40-100 nm secreted from multivesicular bodies into the extracellular environment by most of the cell types in-vivo and in-vitro. As a natural nanocarrier, exosomes are immunologically inert, biocompatible, and can cross biological barriers like the blood-brain barrier, intestinal barrier, and placental barrier.This review focusses on the role of exosome as a carrier to efficiently deliver a gene for cancer treatment and diagnosis. The methods for loading of nucleic acids onto the exosomes, advantages of exosomes as a smart intercellular shuttle for gene delivery and therapeutic applications as a gene delivery vector for siRNA, miRNA and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and also the limitations of exosomes as a gene carrier are all reviewed in this article.Mostly, electroporation and chemical transfection are used to prepare gene loaded exosomes.Exosome-mediated delivery is highly promising and advantageous in comparison to the current delivery methods for systemic gene therapy. Targeted exosomes, loaded with therapeutic nucleic acids, can efficiently promote the reduction of tumor proliferation without any adverse effects.In the near future, exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer.

Exosome

Nanocarriers

10.2174/1568009620666200924154149

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Citations (21)

Author response for "The Rise of Extracellular Vesicles as New Age Biomarkers in Cancer Diagnosis: Promises and Pitfalls"

Suraj Bamankar Vaishali Londhe

Extracellular Vesicles

10.1177/15330338221149266/v2/response1

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Oral jelly of metformin hydrochloride – Formulation development using Design of Experiments and characterization

Journal of Drug Delivery Science and Technology (2021)

Shailesh Kulkarni Vaishali Londhe

Metformin Hydrochloride

Hydrochloride

10.1016/j.jddst.2021.102519

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Lurasidone-β-cyclodextrin complexes: Physicochemical characterization and comparison of their antidepressant, antipsychotic activities against that of self microemulsifying formulation

Journal of Molecular Structure (2017)

Vaishali Londhe Aishwarya B. Deshmane Sarita R. Singh Yogesh A. Kulkarni

Pharmacodynamics

Antipsychotic drug

Lurasidone

10.1016/j.molstruc.2017.12.042

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Citations (16)

Inclusion Complexes of Hydroxy Propyl-β-Cyclodextrin and Paliperidone: Preparation and Characterization

Current Drug Discovery Technologies (2015)

Atul P. Sherje Vaishali Londhe

In the present investigation, an attempt has been made to improve aqueous solubility of a BCS class II drug by making an inclusion complex with Hydroxypropyl-β-cyclodextrin (HP-β-CD). Paliperidone (PALI) was selected as a model drug for the study. It is practically insoluble in water with low oral bioavailability. It is a major active metabolite of risperidone approved for the treatment of schizophrenia in adults. The inclusion complexes were prepared in 1:1 (PALI: HP-β-CD) molar ratio. Phase solubility studies were performed according to Higuchi Connors method to determine the optimum conditions for the complexation. The prepared solid inclusion complexes were characterized by Differential Scanning Calorimetry (DSC), Fourier- Transform Infrared Spectroscopy (FT-IR), Powder X-ray Diffractometry (PXRD), Scanning Electron Microscopy (SEM) and Proton Nuclear Magnetic Resonance Spectroscopy ((1)H-NMR). Dissolution study was performed using USP apparatus II in phosphate buffer, pH 6.8 (37 ± 0.5°C). The solid state characterization studies confirmed the formation of inclusion complex between PALI and HP-β-CD. The aqueous solubility and in-vitro dissolution study showed that the solubility and dissolution rate of drug were considerably improved by complexation with HP-β-CD with respect to the drug alone. The enhanced solubility and dissolution may help to improve in-vivo performance of PALI. Thus, the binary complexation of PALI with HP-β-CD can be used as an approach for its solubility enhancement.

10.2174/1570163812666150109103618

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Citations (16)