Mona M. El-Naa

University of Sadat City

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Gina S. El-Feky

Academy of Scientific Research and Technology

Mohamed F. El‐Refaei

University of Sadat City

Amany I. El-Brairy

October University of Modern Sciences and Arts

Sanaa A. Kenawy

Cairo University

Mohamed F. Attia

University of North Carolina at Chapel Hill

A. Salem

Suez Canal University

Abd El-Monem Abd El-Kader El-Torgoman

Menoufia University

Samah El-Ghlban

Menoufia University

Wesam A. Nasif

Umm al-Qura University

Azza S. Awad

Ahram Canadian University

Cooperative Institutions

National Research Centre

Cairo University

October University of Modern Sciences and Arts

Ain Shams University

Menoufia University

Tanta University

Al-Azhar University

Assiut University

National Water Research Center

Al-Azhar University

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Design, synthesis and structure–activity relationship of novel semi-synthetic flavonoids as antiproliferative agents

European Journal of Medicinal Chemistry (2014)

Fatma A. Ragab Tawfeek Ahmed Ali Yahya Mona M. El-Naa Reem K. Arafa

Flavones

Structure–activity relationship

10.1016/j.ejmech.2014.06.007

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Citations (34)

Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity

BMC Complementary and Alternative Medicine (2017)

Riham O. Bakr Mona M. El-Naa Soumaya S. Zaghloul Mahmoud Mohamed Omar

Nymphaea alba L. represents an interesting field of study. Flowers have antioxidant and hepatoprotective effects, rhizomes constituents showed cytotoxic activity against liver cell carcinoma, while several Nymphaea species have been reported for their hepatoprotective effects. Leaves of N. alba have not been studied before. Therefore, in this study, in-depth characterization of the leaf phytoconstituents as well as its antioxidant and hepatoprotective activities have been performed where N. alba leaf extract was evaluated as a possible therapeutic alternative in hepatic disorders.The aqueous ethanolic extract (AEE, 70%) was investigated for its polyphenolic content identified by high-resolution electrospray ionisation mass spectrometry (HRESI-MS/MS), while the petroleum ether fraction was saponified, and the lipid profile was analysed using gas liquid chromatography (GLC) analysis and compared with reference standards. The hepatoprotective activity of two doses of the extract (100 and 200 mg/kg; P.O.) for 5 days was evaluated against CCl4-induced hepatotoxicity in male Wistar albino rats, in comparison with silymarin. Liver function tests; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT) and total bilirubin were performed. Oxidative stress parameters; malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC) as well as inflammatory mediator; tumour necrosis factor (TNF)-α were detected in the liver homogenate. Histopathological examination of the liver and immunohistochemical staining of caspase-3 were performed RESULTS: Fifty-three compounds were tentatively identified for the first time in N.alba leaf extract, where ellagitannins represent the main identified constituents. Nine hydrocarbons, two sterols and eleven fatty acids were identified in the petroleum ether extract where, palmitic acid and linolenic acids represented the major saturated and unsaturated fatty acid respectively. N.alba AEE significantly improved the liver function, oxidative stress parameters as well as TNF-α in addition to the amelioration of histopathological features of the liver and a profound decrease in caspase-3 expression.These results shed light on the hepatoprotective effect of N. alba that is comparable with that of silymarin. The antioxidant activities of N. alba extract in addition to the inhibition of crucial inflammatory mediator, as TNF-α, might be the possible hepatoprotective mechanisms.

Petroleum ether

10.1186/s12906-017-1561-2

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Citations (31)

Comparative study on beneficial effects of vitamins B and D in attenuating doxorubicin induced cardiotoxicity in rats: Emphasis on calcium homeostasis

Biomedicine & Pharmacotherapy (2021)

Heba H. Awad Marwa O. El-Derany Eman M. Mantawy Haidy E. Michel Mona M. El-Naa

The use of doxorubicin (DOX) to treat various tumors is limited by its cardiotoxicity. This study aimed to investigate and compare the cardioprotective effects of nicotinamide (NAM) and alfacalcidol (1α(OH)D3), against DOX-induced cardiotoxicity. Sprague Dawley male rats received DOX (5 mg/kg, i.p.) once/week for four consecutive weeks. Treated groups received either NAM (600 mg/kg, p.o.) for 28 consecutive days or 1α(OH)D3 (0.5 ug/kg, i.p.) once/week for four consecutive weeks. DOX elicited marked cardiac tissue injury manifested by elevated serum cardiotoxicity indices, conduction and histopathological abnormalities. Both NAM and 1α(OH)D3 successfully reversed all these changes. From the mechanistic point of view, DOX provoked intense cytosolic and mitochondrial calcium (Ca2+) overload hence switching on calpain1 (CPN1) and mitochondrial-mediated apoptotic cascades as confirmed by upregulating Bax and caspase-3 while downregulating Bcl-2 expression. DOX also disrupted cardiac bioenergetics as evidenced by adenosine triphosphate (ATP) depletion and a declined ATP/ADP ratio. Moreover, DOX upregulated the Ca2+ sensor; calmodulin kinase II gamma (CaMKII-δ) which further contributed to cardiac damage. Interestingly, co-treatment with either NAM or 1α(OH)D3 reversed all DOX associated abnormalities by preserving Ca2+ homeostasis, replenishing ATP stores and obstructing apoptotic events. Additionally, DOX prompted nuclear factor kappa B (NF-κB) dependent inflammatory responses and subsequently upregulated interleukin-6 (IL-6) expression. Co-treatment with NAM or 1α(OH)D3 effectively obstructed these inflammatory signals. Remarkably, NAM showed superior beneficial cardioprotective properties over 1α(OH)D3. Both NAM and 1α(OH)D3 efficiently attenuated DOX-cardiomyopathy mainly via preserving Ca2+ homeostasis and diminishing apoptotic and inflammatory pathways. NAM definitely exhibited effective cardioprotective capabilities over 1α(OH)D3.

Cardiotoxicity

Homeostasis

10.1016/j.biopha.2021.111679

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Citations (28)

Corrigendum to “Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats” [J. Drug Deliv. Sci. Technol. 72 (2022) 103388]

Journal of Drug Delivery Science and Technology (2022)

A. Salem Amira Montaser Mona M. El-Naa Gina S. El-Feky Samah El-Ghlban

Alpha (finance)

10.1016/j.jddst.2022.103647

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Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats

Journal of Drug Delivery Science and Technology (2022)

A. Salem Ahmed Saeed Saad Mona M. El-Naa Gina S. El-Feky Samah El-Ghlban

10.1016/j.jddst.2022.103388

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Citations (2)

Flexible nano-sized lipid vesicles for the transdermal delivery of colchicine; in vitro/in vivo investigation

Journal of Drug Delivery Science and Technology (2018)

Gina S. El-Feky Mona M. El-Naa Azza A. Mahmoud

Ex vivo

Zeta potential

10.1016/j.jddst.2018.10.036

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Citations (24)

Antioxidant and Apoptotic Effects of Caffeic Acid Phenethyl Ester Induced Marked Inhibition on Human Breast Cancer Cell Line

Asian Journal of Biochemistry (2010)

Mohamed F. El-Refa Mona M. El-Naa

Cancer cell lines

MCF-7

10.3923/ajb.2011.82.89

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Citations (4)

Effect of Thymoquinone and Omega-3 on Intestinal Ischemia/Reperfusion Induced Hepatic Dysfunction in Rats

British Journal of Pharmacology and Toxicology (2014)

Sanaa A. Kenawy Mohamed E. H. ElSayed Azza S. Awad Ahmed M. Fayez Mona M. El-Naa

Intestinal Ischemia-Reperfusion (I/R) is a complex phenomenon causing local and remote tissue destruction and multiple-organ dysfunction. The present study investigates the effect of thymoquinone and omega-3 on intestinal I/R-induced hepatic dysfunction. Sixty four Wistar albino rats were randomly allocated into four experimental groups: sham control, intestinal I/R control, thymoquinone (10 mg/kg) and omega-3 (300 mg/kg) pre-treated groups respectively. Intestinal I/R model were established by clamping the superior mesenteric artery for 30 min followed by 60 min reperfusion. Serum levels of aspartate Amino Transferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP) were measured. Hepatic tissue contents of Malondialdehyde (MDA), reduced Glutathione (GSH), Myeloperoxidase (MPO) and Tumor Necrosis Factor alpha (TNF-α) and Superoxide Dismutase (SOD) activity were measured. Apoptosis in hepatic tissue cells was determined by immunities to chemical analysis of caspase-3. Hepatic histopathological examination was carried out. Intestinal I/R elevated serum AST, ALT and ALP levels. In-addition, hepatic tissue SOD activity and GSH content were decreased, while MDA, MPO and TNF-&alpha contents were increased. Pre-treatment with thymoquinone or omega-3 corrected the histopathological changes and serum AST, ALT, ALP levels as well as hepatic tissue activity of SOD and GSH contents. In-addition, hepatic tissue contents of MDA and MPO were decreased. Furthermore, immunohistochemical examination showed remarkable activation of caspase-3 activity in hepatic tissue after intestinal I/R, which were corrected by thymoquinone or omega-3 pre-treatment. The protective potential of thymoquinone and omega-3 on hepatic dysfunction could be attributed to the known antioxidant, antiapoptotic and anti-inflammatory effects of test drugs.

Thymoquinone

Malondialdehyde

10.19026/bjpt.5.5183

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Composite carbohydrate interpenetrating polyelectrolyte nano-complexes (IPNC) as a controlled oral delivery system of citalopram HCl for pediatric use: in-vitro/in-vivo evaluation and histopathological examination

Drug Delivery and Translational Research (2018)

Rabab Kamel Haidy Abbas Mona M. El-Naa

10.1007/s13346-018-0506-8

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Citations (6)

Inhibitory effect of caffeic acid phenethyl ester on mice bearing tumor involving angiostatic and apoptotic activities