J. K. M. C. Gonsalves

Universidade Federal de Sergipe

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Rogéria de Souza Nunes

Universidade Federal de Sergipe

Ricardo LC Albuquerque‐Júnior

Universidade Tiradentes

Lucindo José Quintans‐Júnior

Universidade Federal de Sergipe

A. M. Costa

Universidade Federal de Sergipe

Sócrates C.H. Cavalcanti

Universidade Federal de Sergipe

Enilton A. Camargo

Universidade Federal de Sergipe

Damião Pergentino de Sousa

Universidade Federal da Paraíba

Waldecy Lucca‐Júnior

Universidade Federal de Sergipe

Vera Lúcia Corrêa Feitosa

Universidade Federal de Sergipe

Jullyana de Souza Siqueira Quintans

Universidade Federal de Sergipe

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Universidade Federal de Sergipe

Universidade Tiradentes

Brazilian Network Information Center

Faculdades Guarulhos

Universidade Federal do Piauí

Universidade Federal do Vale do São Francisco

Universidade São Francisco

Universidade Federal do Rio Grande do Norte

Universidade Federal de Ciências da Saúde de Porto Alegre

Universidade Federal do Rio Grande do Sul

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Microencapsulação do óleo essencial de Citrus sinensis (L) Osbeck pelo método da coacervação simples

J. K. M. C. Gonsalves A. M. Costa Damião Pergentino de Sousa Sócrates C.H. Cavalcanti Rogéria de Souza Nunes

Dengue, a major public health problem in the world, is transmitted by Aedes aegypti. The chemical control, mainly organophosphates, is one of the most effective. However, the resistance shows up as a major problem. A viable alternative vector control would be the use of monoterpenes or their complex mixtures (essential oils). Limonene, the main constituent of essential oil of Citrus sinensis, has strong larvicidal activity against larvae of Aedes aegypti. Therefore, the use of oil in the larvicidal control of Aedes aegypti proved to be adequate. However, the low stability of essential oil (volatility, oxidation of the constituents, among others), use direct disadvantage and needs to be microencapsulation. In this sense microcapsules were prepared by simple coacervation and characterized by FTIR. Chitosan was used as a polymer forming wall showed a degree of deacetylation of 87.31%, the yield of the process of formation of microcapsules was 82.81% and the encapsulation efficiency of the essential oil was 31.16%. With the spectroscopic characterization was possible to observe the cross-linking of chitosan by glutaraldehyde (formation of imine grouping - 1656 cm-1).

Citrus × sinensis

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Improvement of wound tissue repair by chitosan films containing (–)‐borneol, a bicyclic monoterpene alcohol, in rats

International Wound Journal (2014)

Rosana de Souza Siqueira Barreto Jullyana de Souza Siqueira Quintans André Sales Barreto Ricardo LC Albuquerque‐Júnior Juliana Gouveia Galvão

The aim of this study was to investigate the wound-healing activity of (-)-borneol (BOR) incorporated in chitosan film on healing protocol in rodents. To assess the BOR wound-healing potential, male Wistar rats were subjected to a full-thickness excisional wound. The animals were divided into three groups: dressed with chitosan-based film (QUIN); dressed with chitosan-based film containing 0·5% BOR (QUIBO05); or dressed with chitosan-based film containing 1% BOR (QUIBO1). Dressing the wound areas and histological analysis were performed on the 3rd, 7th, 14th, and 21st days. The myeloperoxidase (MPO) activity was assessed on the third and seventh days after surgical procedures. Wounds dressed with chitosan-based film containing BOR reduced significantly the MPO activity (P < 0·001), showed significantly larger wound retraction rates (7 days, P < 0·05), improved the granulation reaction, and also provided better collagenisation density and arrangement during wound healing. It is suggested that BOR modulates the wound-healing process and is a promising compound to be used in wound care. This product may be quite useful in improving wound healing and could be a new biotechnological product with healing properties and clinical application. Further ongoing studies will enable us to understand the precise mechanisms whereby BOR improves the wound-healing process.

Granulation tissue

Borneol

Granulation

Wound dressing

Wound treatment

Wound care

10.1111/iwj.12385

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Citations (24)