Zoi F. Plyta

National Centre of Scientific Research "Demokritos"

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Elias A. Couladouros

Agricultural University of Athens

Vassilios P. Papageorgiou

Aristotle University of Thessaloniki

ÉR

Éric Rose

McGill University

Damien Prim

Centre National de la Recherche Scientifique

Jean‐Philippe Tranchier

Centre National de la Recherche Scientifique

A. T. Strongilos

Piedmont Athens Regional

F. Rose‐Munch

Sorbonne Université

Audrey Auffrant

École Polytechnique

Vassilios Roussis

National and Kapodistrian University of Athens

Andreana N. Assimopoulou

Aristotle University of Thessaloniki

Cooperative Institutions

Centre National de la Recherche Scientifique

Agricultural University of Athens

Université Paris-Sud

National Centre of Scientific Research "Demokritos"

Laboratoire de Synthèse Organique

Université Paris-Saclay

Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion

Institut Galien Paris-Saclay

Université Paris Cité

Sorbonne Université

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Synthesis of nitrile ligands bearing tricarbonyl (η6-arene)chromium complexes and conjugated spacers

Tetrahedron Letters (2000)

Jean‐Philippe Tranchier René Chavignon Damien Prim Audrey Auffrant Zoi F. Plyta

10.1016/s0040-4039(00)00454-8

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Citations (28)

Inhibition of topoisomerase I by naphthoquinone derivatives

Bioorganic & Medicinal Chemistry Letters (1998)

Zoi F. Plyta Tianhu Li Vassilios P. Papageorgiou Antonios S. Mellidis Andreana N. Assimopoulou

Naphthoquinone

1,4-Naphthoquinone

10.1016/s0960-894x(98)00600-3

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Citations (77)

ChemInform Abstract: Efficient Synthesis of Aminonaphthoquinones and Azidobenzohydroquinones: Mechanistic Considerations of the Reaction of Hydrazoic Acid with Quinones. An Overview

ChemInform (1997)

Elias A. Couladouros Zoi F. Plyta Serkos A. Haroutounian Vassilios P. Papageorgiou

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Hydrazoic acid

10.1002/chin.199718291

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Citations (0)

ChemInform Abstract: Heteroannulation of Naphthoquinones. Studies on the Reaction of 2‐ Bromo‐2,3‐dihydronaphthoquinone Derivatives with 1,2‐Binucleophiles.

ChemInform (1996)

Elias A. Couladouros Zoi F. Plyta Theodoros Iliadis Vassilios Roussis Vassilios P. Papageorgiou

10.1002/chin.199650040

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ChemInform Abstract: Asymmetric Synthesis of Alkannin and Shikonin.

ChemInform (1998)

Elias A. Couladouros Zoi F. Plyta A. T. Strongilos Vassilios P. Papageorgiou

10.1002/chin.199801259

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Cover Picture: Chem. Eur. J. 8/2002

Chemistry - A European Journal (2002)

Elias A. Couladouros A. T. Strongilos Vassilios P. Papageorgiou Zoi F. Plyta

The cover picture shows a schematic representation of the parallel history of alkannin and shikonin. Dioscorides, the founder of pharmacognosy, in his work “De Materia Medica”, around 77 AD (book shown under the magnifying lens), described the therapeutic properties of the roots of the plant Anchusa tinctoria (also known as Alkanna tinctoria). Concurrently, at the other half of the northern hemisphere, in China, the extracts from the roots of the plant Lithospermum erythrorhizon were used for silk dyeing and as crude anti-inflammatory drugs by the famous surgeon Hua To. At the beginning of 20th century, Japanese chemists Majima and Kuroda isolated a red pigment from Lithospermum erythrorhizon, which later proved to be shikonin (structure shown in the picture). In 1936, Brockmann “connected” the two stories by elucidating the structure of the red component of Anchusa tinctoria to be the optical antipode of shikonin, namely alkannin (shown in the mirror). Since then, many articles regarding the chemistry, biology, and pharmacological profile of alkannin, shikonin, the racemic mixture (shikalkin), and their derivatives have been reported. Today, the title compounds and their analogues constitute the major active ingredients of several commercially available ointments, such as HELIXDERM and Koushikon. An efficient and scalable synthesis of these molecules is presented by E. A. Couladouros et al. on p. 1795 ff.

10.1002/1521-3765(20020415)8:8<1757::aid-chem1757>3.0.co;2-r

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Efficient Synthesis of Aminonaphthoquinones and Azidobenzohydroquinones: Mechanistic Considerations of the Reaction of Hydrazoic Acid with Quinones. An Overview

The Journal of Organic Chemistry (1997)

Elias A. Couladouros Zoi F. Plyta Serkos A. Haroutounian Vassilios P. Papageorgiou

Parameters useful to predict and control the reaction outcome of conjugate addition of hydrazoic acid to quinones have been studied, and the optimum conditions for the efficient synthesis of aminonaphthoquinones and azidobenzohydroquinones are reported. The application of this reaction for the efficient formal synthesis of dephostatin is also presented.

Hydrazoic acid

Conjugate

10.1021/jo9614708

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Citations (59)

ChemInform Abstract: Tricarbonyl(η⁶‐arene)chromium and Ferrocene Complexes Linked with Aromatic Spacers.

ChemInform (1999)

Zoi F. Plyta Damien Prim Jean‐Philippe Tranchier F. Rose‐Munch Éric Rose

10.1002/chin.199947189

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Citations (0)

ChemInform Abstract: Inhibition of Topoisomerase I by Naphthoquinone Derivatives.

ChemInform (1999)

Zoi F. Plyta Tianhu Li Vassilios P. Papageorgiou Antonios S. Mellidis Andreana N. Assimopoulou

Naphthoquinone

10.1002/chin.199910105

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Citations (1)

Heteroannulation of naphthoquinones. Studies on the reaction of 2‐bromo‐2,3‐dihydronaphthoquinone derivatives with 1,2‐binucleophiles.

Journal of Heterocyclic Chemistry (1996)

Elias A. Couladouros Zoi F. Plyta Theodoros Iliadis Vassilios Roussis Vassilios P. Papageorgiou

Abstract Heterocyclic derivatives of naphthoquinones were synthesized via their 2‐bromo‐2,3‐dehydro‐intermediates. This new route may lead to the formation of benzo[ a ]phenothiazin‐5‐ones, benzo[ f ]quinoxalin‐6‐ones as well as their 1,4 (or 7,10) dihydroxy‐derivatives in high yields. The possible mechanisms involved in the formation of these compounds are discussed.

10.1002/jhet.5570330331

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Citations (3)