Zhi‐Wen Zhou

Wuhan University

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Feng‐Cheng Jia

Wuhan Institute of Technology

An‐Xin Wu

Central China Normal University

Xu Cheng

Lanzhou University

Yan‐Dong Wu

Johns Hopkins Medicine

Qun Cai

Ningbo Medical Center Lihuili Hospital

Deng‐Kui Li

Xi'an Jiaotong University

Shi‐Fen Jiang

Central China Normal University

Xiao‐Hui Wen

Central China Normal University

Qin Zhang

Sichuan University

Si‐Jie Zheng

Central China Normal University

Cooperative Institutions

Chinese Academy of Sciences

Wuhan University

Central China Normal University

Wuhan Institute of Physics and Mathematics

Huazhong University of Science and Technology

Wuhan National Laboratory for Optoelectronics

University of Chinese Academy of Sciences

Lanzhou University

Sichuan University

Hubei Normal University

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A concise construction of 12H-benzo[4,5]thiazolo[2,3-b]quinazolin-12-ones via an unusual TBHP/Na₂CO₃ promoted cascade oxidative cyclization and interrupted Dimroth rearrangement

Chemical Communications (2016)

Zhi‐Wen Zhou Feng‐Cheng Jia Xu Cheng Shi‐Fen Jiang Yan‐Dong Wu

An efficient transition-metal-free cascade reaction has been developed for the facile synthesis of 12H-benzo[4,5]thiazolo[2,3-b]quinazolin-12-one derivatives from commercially available isatins and 2-haloaryl isothiocyanates. A preliminary mechanistic study suggested an interrupted Dimroth rearrangement was the key step for the successful transformation.

10.1039/c6cc09376k

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Citations (28)

Synthesis of SCF₃‐Substituted Sulfonium Ylides from Sulfonium Salts or α‐Bromoacetic Esters

Advanced Synthesis & Catalysis (2021)

Yushan Xiao Yimin Jia Jinfeng Huang Xiangyu Li Zhi‐Wen Zhou

Abstract A metal‐free direct trifluoromethylthiolation of sulfonium ylides with an electrophilic trifluoromethylthiolating reagent has been established, in which sulfonium salt or α‐bromoacetic ester is employed as sulfonium ylide precursors. This trifluoromethylthiolation enables the straightforward construction of SCF 3 ‐substituted sulfonium ylides from a wide range of substrates, including ketones, esters, and even PEGylated substrates. Moreover, the application of this approach in large‐scale preparation and the fluorescence and fluorine‐19 magnetic resonance imaging capabilities of the product are also explored. magnified image

Sulfonium

Ylide

10.1002/adsc.202101271

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Citations (3)

Copper-Catalyzed Multicomponent Domino Reaction of 2-Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives

The Journal of Organic Chemistry (2016)

Xu Cheng Feng‐Cheng Jia Zhi‐Wen Zhou Si‐Jie Zheng Li Han

An efficient three-component domino reaction of 2-bromoaldehydes, benzylamines, and sodium azide has been developed for the synthesis of quinazoline derivatives. This domino process involves copper-catalyzed SNAr, oxidation/cyclization, and denitrogenation sequences. The mild catalytic system enabled the effective construction of three C–N bonds in one operation.

Sodium azide

Quinazoline

Domino

10.1021/acs.joc.5b02843

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ChemInform Abstract: Divergent Synthesis of Quinazolin‐4(3H)‐ones and Tryptanthrins Enabled by a tert‐Butyl Hydroperoxide/K₃PO₄‐Promoted Oxidative Cyclization of Isatins at Room Temperature.

ChemInform (2016)

Feng‐Cheng Jia Zhi‐Wen Zhou Xu Cheng Yan‐Dong Wu An‐Xin Wu

Abstract A facile synthesis of various functionalized quinazolinones from commercially available isatins and amidine hydrochlorides is presented.

10.1002/chin.201644157

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Citations (0)

Switchable Access to 3-Carboxylate-4-quinolones and 1-Vinyl-3-carboxylate-4-quinolones via Oxidative Cyclization of Isatins and Alkynes

Organic Letters (2018)

Shi‐Fen Jiang Xu Cheng Zhi‐Wen Zhou Qin Zhang Xiao‐Hui Wen

An efficient transition-metal-free oxidative cyclization reaction using isatins and alkynes for the facile synthesis of structurally diverse 4-quinolones has been developed. Intriguingly, switchable access to substituted 3-carboxylate-4-quinolones and 1-vinyl-3-carboxylate-4-quinolones could be achieved by choosing a different base in the reaction. The obtained products could undergo further transformations, increasing the application potential of the method in organic synthesis.

Carboxylate

Base (topology)

10.1021/acs.orglett.8b01645

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Citations (35)

ChemInform Abstract: Intramolecular Decarboxylative Coupling as the Key Step in Copper‐Catalyzed Domino Reaction: Facile Access to 2‐(1,3,4‐Oxadiazol‐2‐yl)aniline Derivatives.

ChemInform (2015)

Xu Cheng Feng‐Cheng Jia Qun Cai Deng‐Kui Li Zhi‐Wen Zhou

Abstract (Oxadiazolyl)aniline derivatives (III) and (V) are obtained by a copper‐catalyzed domino reaction of simple and easily available isatins and hydrazides.

Domino

Cascade reaction

10.1002/chin.201532156

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ChemInform Abstract: Copper‐Catalyzed Multicomponent Domino Reaction of 2‐Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives.

ChemInform (2016)

Xu Cheng Feng‐Cheng Jia Zhi‐Wen Zhou Si‐Jie Zheng Li Han

Sodium azide

10.1002/chin.201632175

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ChemInform Abstract: Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy.

ChemInform (2016)

Feng‐Cheng Jia Zhi‐Wen Zhou Xu Cheng Qun Cai Deng‐Kui Li

The process is based on an elegant domino reaction between ortho-brominated, chlorinated, iodinated, or fluorinated benzonitriles, aryl or hetarylaldehydes, and sodium azide.

Domino

10.1002/chin.201604153

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Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy

Organic Letters (2015)

Feng‐Cheng Jia Zhi‐Wen Zhou Xu Cheng Qun Cai Deng‐Kui Li

A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved consecutive iron-mediated [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, oxidation, and copper-catalyzed denitrogenation sequences. The formed structure is the privileged core in drugs and bioactive molecules.

Domino

Sodium azide

10.1021/acs.orglett.5b02020

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Citations (56)

Temperature‐Controlled Base‐Promoted Cyclization for the Synthesis of 2‐Amino‐4H‐benzo[d][1,3]thiazin‐4‐ones and 2‐Thioxo‐4(3H)‐quinazolinones

Asian Journal of Organic Chemistry (2017)

Zhi‐Wen Zhou Feng‐Cheng Jia Xu Cheng Shi‐Fen Jiang Yan‐Dong Wu

Abstract A base‐promoted and highly selective temperature‐dependent tandem oxidation/decarboxylative cyclization of isothiocyanates and isatins has been developed. This method allows the chemodivergent synthesis of 4 H ‐benzo[ d ][1,3]thiazin‐4‐ones and 2‐thioxo‐2,3‐dihydroquinazolin‐4(1 H )‐ones in moderate to high yields.

Tandem

Base (topology)

10.1002/ajoc.201700443

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Citations (8)