Sarath P. Gunasekera

Smithsonian Marine Station

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Valerie J. Paul

Smithsonian Marine Station

Ross E. Longley

Oklahoma Medical Research Foundation

M. Uvais S. Sultanbawa

University of Peradeniya

Hendrik Luesch

University of Florida

Shirley A. Pomponi

Harbor Branch Oceanographic Institute

Francis J. Schmitz

University of Oklahoma

Amy E. Wright

Massachusetts General Hospital

Peter J. McCarthy

Harbor Branch Oceanographic Institute

Malika Gunasekera

Harbor Branch Oceanographic Institute

Max Teplitski

University of Florida

Cooperative Institutions

University of Florida

Harbor Branch Oceanographic Institute

Smithsonian Marine Station

University of Hawaii System

Cornell University

University of Hawaiʻi at Mānoa

Florida Atlantic University

Smithsonian Institution

National Cancer Institute

University of Peradeniya

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Sarasinoside A1: a saponin containing amino sugars isolated from a sponge

The Journal of Organic Chemistry (1988)

Francis J. Schmitz Mohamad B. Ksebati Sarath P. Gunasekera Santosh Kumar Agarwal

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSarasinoside A1: a saponin containing amino sugars isolated from a spongeFrancis J. Schmitz, Mohamad B. Ksebati, Sarath P. Gunasekera, and Santosh AgarwalCite this: J. Org. Chem. 1988, 53, 25, 5941–5947Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/jo00260a025https://doi.org/10.1021/jo00260a025research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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10.1021/jo00260a025

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Citations (35)

Natural products from Caribbean octocorals demonstrate bioactivity against Vibrio coralliilyticus strains

Coral Reefs (2024)

Matteo Monti Aurora Giorgi Valerie J. Paul Sarath P. Gunasekera Lawrence J. Houk

10.1007/s00338-024-02516-6

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A New Cytotoxic Sterol Methoxymethyl Ether from a Deep Water Marine Sponge Scleritoderma sp. cf. paccardi

Journal of Natural Products (1996)

Sarath P. Gunasekera Michelle Kelly‐Borges Ross E. Longley

24(R)-Methyl-5α-cholest-7-enyl 3β-methoxymethyl ether (1), a new sterol ether, has been isolated from a deep-water marine sponge Scleritoderma sp. cf. paccardi. Compound 1 exhibited in vitro cytotoxicity against the cultured murine P-388 tumor cell line with an IC50 of 2.3 μg/mL. The isolation and structure elucidation of 1 by NMR spectroscopy is described.

Sponge

10.1021/np9600311

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Citations (16)

Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta

The Journal of Organic Chemistry (1991)

Sarath P. Gunasekera Malika Gunasekera Peter J. McCarthy

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissolutaSarath P. Gunasekera, Malika Gunasekera, and Peter McCarthyCite this: J. Org. Chem. 1991, 56, 16, 4830–4833Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://doi.org/10.1021/jo00016a006RIGHTS & PERMISSIONSArticle Views453Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (453 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts

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10.1021/jo00016a006

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Citations (89)

Synthesis of microcolin analogs using trimethylsilylated lactams

Tetrahedron Letters (1997)

Ralph–Heiko Mattern Sarath P. Gunasekera Oliver J. McConnell

Lactam

10.1016/s0040-4039(97)00336-5

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Citations (15)

Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics

Marine Drugs (2023)

Julie L. Meyer Sarath P. Gunasekera A. L. Brown Yousong Ding Stephanie Miller

Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. Although black band disease mats are predominantly composed of the cyanobacterial species Roseofilum reptotaenium, other filamentous cyanobacterial strains and bacterial heterotrophs are readily detected. Through chemical ecology and metagenomic sequencing, we uncovered cryptic strains of Roseofilum species from Siderastrea siderea corals that differ from those on other corals in the Caribbean and Pacific. Isolation of metabolites from Siderastrea-derived Roseofilum revealed the prevalence of unique forms of looekeyolides, distinct from previously characterized Roseofilum reptotaenium strains. In addition, comparative genomics of Roseofilum strains showed that only Siderastrea-based Roseofilum strains have the genetic capacity to produce lasso peptides, a family of compounds with diverse biological activity. All nine Roseofilum strains examined here shared the genetic capacity to produce looekeyolides and malyngamides, suggesting these compounds support the ecology of this genus. Similar biosynthetic gene clusters are not found in other cyanobacterial genera associated with black band disease, which may suggest that looekeyolides and malyngamides contribute to disease etiology through yet unknown mechanisms.

10.3390/md21020076

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Chemical investigation of ceylonese plants. Part 23. Extractives of Hydnocarpus octandra Thw. (Flacourtiaceae); isolation and characterisation of six new triterpenoids

Journal of the Chemical Society. Perkin transactions I/Journal of the Chemical Society. Perkin transactions. I (1977)

Sarath P. Gunasekera M. Uvais S. Sultanbawa

From the bark H. octandra-Thw., six new triterpenoids named octandrolal (3a), octandrolol (3c), octandrolic acid (3e), octandronal (3b), octandronol (3d), and octandronic acid (3f) have been isolated, interrelated, and identified. Seven other, known triterpenoids and mangostin have also been isolated and characterised. Timber and fruit pericarp gave β-sitosterol and friedelin. Molecular rotation differences of friedelane derivatives are discussed.

Friedelin

Isolation

10.1039/p19770000418

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Citations (19)

Marine Natural Products: Pyrrololactams from Several Sponges

Journal of Natural Products (1985)

Francis J. Schmitz Sarath P. Gunasekera Vijai Lakshmi L. M. Viranga Tillekeratne

Two pyrrololactams, likely degradation products of more complex known guanidines, were isolated from several marine sponges. 5-Bromo- and 4,5-dibromopyrrole-1-carboxylic acid methyl esters were also isolated. A complex guanidine metabolite, poorly soluble in DMSO, was found to give sharp, reproducible nmr spectra in acid media.

Sponge

Guanidine

10.1021/np50037a008

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Citations (66)

Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida

Molecules (2022)

Sarath P. Gunasekera Sofia Kokkaliari Ranjala Ratnayake Thomas Sauvage Larissa A. H. dos Santos

Dysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound was determined by spectroscopic methods and comparisons between HRMS and NMR data with its reported methyl ester. The absolute configuration of the single chiral center was determined by the conversion of 1 to the methyl ester and the comparison of its specific rotation data with the two known methyl ester isomers, 2 and 3. Molecular sequencing with 16S rDNA indicated that this cyanobacterium differs from Caldora penicillata (Oscillatoriales) and represents a previously undocumented and novel Caldora species. Dysidazirine (2) showed weak cytotoxicity against HCT116 colorectal cancer cells (IC50 9.1 µM), while dysidazirine carboxylic acid (1) was non-cytotoxic. Similar cell viability patterns were observed in RAW264.7 cells with dysidazirine only (2), displaying cytotoxicity at the highest concentration tested (50 µM). The non-cytotoxic dysidazirine carboxylic acid (1) demonstrated anti-inflammatory activity in RAW264.7 cells stimulated with LPS. After 24 h, 1 inhibited the production of NO by almost 50% at 50 µM, without inducing cytotoxicity. Compound 1 rapidly decreased gene expression of the pro-inflammatory gene iNOS after 3 h post-LPS treatment and in a dose-dependent manner (IC50 ~1 µM); the downregulation of iNOS persisted at least until 12 h.

Sponge

IC50

10.3390/molecules27051717

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Citations (13)

Plant Anticancer Agents XX.* Constituents ofNicandra physalodes

Planta Medica (1981)

Sarath P. Gunasekera G. Cordell Nikki L. Farnsworth

The known withanolide nicandrenone (1) is primarily responsible for the in vitro cytotoxicity of extracts prepared from Nicandra physalodes (Solanaceae).

Withanolide

10.1055/s-2007-971530

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Citations (14)