Hiroyuki Ishida

Kyoto City Hospital

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Toshihiko Imamura

Kyoto Prefectural University of Medicine

Takao Yoshihara

Osaka University

Akira Morimoto

Kobe University

Fuminori Katsukawa

Keio University

Masami Inoue

Osaka Medical Center for Cancer and Cardiovascular Diseases

Shinsaku Imashuku

Suita Tokushukai Hospital

Katsuyoshi Koh

Saitama Children's Medical Center

Yuko Oguma

Keio University

Hajime Hosoi

Doshisha Women's College of Liberal Arts

Souichi Adachi

Kyoto University

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Kyoto Prefectural University of Medicine

118

Kyoto University

117

Keio University

114

The University of Tokyo

Osaka University

Nagoya University

National Hospital Organization

Tohoku University

Kyushu University

Pediatrics and Genetics

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Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan

Modern Rheumatology (2022)

Hidehiko Narazaki Shinji Akioka Y. Akutsu Mariko Araki Mikiya Fujieda

Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted, they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan registry database, which was established to continuously collect data for paediatric rheumatic diseases.Pediatric Rheumatology International Collaborate Unit Registry version 2 (PRICUREv2) is a registry database established by the Pediatric Rheumatology Association of Japan. The registry data were analysed for the age of onset, time to diagnosis, sex differences, seasonality, and other factors.Our data showed the same trend regarding rates of paediatric rheumatic diseases reported in Japan and other countries. The age of onset was lower in juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis and higher in systemic lupus erythematosus and Sjögren's syndrome. The time to diagnosis was relatively short in JIA and systemic lupus erythematosus but longer in juvenile dermatomyositis and Sjögren's syndrome. Rheumatoid factor-positive polyarticular JIA showed a seasonality cluster with regard to onset.PRICUREv2 aided the retrieval and evaluation of current epidemiological information on patients with paediatric rheumatic diseases. It is expected that the data collection will be continued and will be useful for expanding research in Japan.

Juvenile Dermatomyositis

Juvenile rheumatoid arthritis

10.1093/mr/roac112

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Citations (3)

LSD1 Inhibitor Activates Retinoic Acid Pathway in MLL Fusion Positive Acute Myeloid Leukemia

Blood (2012)

Mio Yano Toshihiko Imamura Kenichi Sakamoto Hideki Yoshida Atsushi Fujiki

Tretinoin

10.1182/blood.v120.21.1345.1345

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Exercise Intensities and Enjoyment Derived by Senior Short Tennis Players : Comparison of Game Effects with Opponents of Different Combined Skill Levels

Journal of Japan Society of Sports Industry (2014)

Noboru Harada Yuko Oguma Hiroyuki Ishida Takehiko SANO

PURPOSE : This study aims to verify the effect of differences in the skill level of opponents and doubles partners regarding exercise intensity and enjoyment of healthy senior people with no experience in playing tennis or short tennis when playing doubles games of short tennis.METHODS : Twenty-four Japanese senior novices (52-77 years old ; 8 males, 16 females) played four different types of doubles games, one game each against two different opponents (novice and skilled) and with two different partners (novice and skilled) . Exercise intensity was assessed by acceleration and heart rate, measured by an ActivTracer® AC-301A (GMS) , while enjoyment was evaluated using the Physical Activity Enjoyment Scale.RESULTS : When playing against novice opponents, mean acceleration with a skilled partner (130.3 mG) was significantly lower than with a novice partner (138.1 mG) , but when playing against skilled opponents, there was no significant difference between a skilled partner and a novice partner. When paired with a skilled partner, mean acceleration against skilled opponents (148.2 mG) was significantly higher than against novice opponents (130.3 mG) , but when paired with a novice partner, there was no significant difference between skilled opponents and novice opponents. There was a significant main effect of the opponents for mean heart rate when playing against skilled opponents (124.8 beats/min) than against novice opponents (120.2 beats/min) , but no significant main effect of partners was evident. There was no significant difference in enjoyment level among games.CONCLUSION : This study demonstrates that when senior people with no experience start playing short tennis, they should carefully consider the skill level of their partners and opponents so that they can gradually increase their exercise intensity. The study also indicates how senior people can derive enjoyment from short tennis irrespective of the level of play of their opponents or doubles partners.

10.5997/sposun.24.1_17

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A CASE OF SYSTEMIC LUPUS ERYTHEMATOSUS ASSOCIATED WITH ACQUIRED VON WILLEBRAND'S SYNDROME AND CIRCULATING ANTICOAGULANT

Nihon Naika Gakkai Zasshi (1984)

Tsuyoshi MAEDA Toshiaki Ando Yasuhiro Nakamura Hiroyuki Ishida Kenjiro Kikuchi

今回,われわれは, SLEに合併した後天性von Willebrand症候群の1例を経験し,凝固学的異常の機序を凝固因子に対するinhibitorの面から詳細に検討する機会を得たので報告する.症例は25才の女性.主訴は月経過多,関節痛と原因不明の発熱.現症では軽度の貧血と肝腫を認めた.検査成績にて,鉄欠乏性貧血,白血球減少,血清梅毒反応偽陽性.抗核抗体(+),抗DNA抗体(+), C3, C4, CH50低値, Coombs test (+),抗白血球抗体および抗血小板抗体(〓)をみた.凝固学的には,第VIII因子凝固活性(19%),第VIII因子関連抗原(30%), von Willebrand因子(36%),第IX, XI, XII因子, prothrombin活性(PT),活性化部分thromboplastin活性(APTT),血小板粘着能およびristocetin凝集能の低下を認めた. ristocetin凝集能が抗lgGkappaと抗IgA抗体により改善したことから,本例の血漿中にIgG kappaおよびIgA分画にristocetin凝集抑制因子が存在することが示唆された.また,抗IgG抗体および抗IgM抗体による中和試験でAPTTが改善したことから,これらの分画に含まれる循環抗凝血素の存在が推測された.そして,この凝固障害はsteroid療法により著明な改善をみた.以上より,本例は後天性von Willebrand症候群を呈し,さらに循環抗凝血素による凝固障害を合併したprobable SLEと診断.この凝固障害発症機序には,少なくとも一部,免疫学的機序が関与しているものと推測された.

Ristocetin

Lupus anticoagulant

Prothrombin time

10.2169/naika.73.680

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Radiation intensity measurement in VUV wavelength region behind strong shock wave for future sample return missions

9th AIAA/ASME Joint Thermophysics and Heat Transfer Conference (2014)

Hiroki Takayanagi Kazuhisa Fujita Hiroyuki Ishida Kazuhiko Yamada Takashi Abe

Radiation measurements in VUV wavelength region behind strong shock wave around 14 km/s at 5 Pa and 12 km/s at 30 Pa with air are conducted in Hyper Velocity Shock Tube developed in JAXA Chofu Space Center in order to expect the radiative heating for future sample return missions from Jupiter Trojans and comet surfaces. For high shock velocity, the thickness of the first diaphragm and pressure inside the compression tube are investigated theoretically and experimentally. Calibrated with a Deuterium lamp, the absolute spectral radiances in VUV region are estimated. By setting it at the measurement positions, spectral radiance in VUV wavelength region can be obtained.

Intensity

Radiant intensity

Sample (material)

10.2514/6.2014-2965

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Citations (4)

Transportation Demand Management

Elsevier eBooks (2006)

Hiroyuki Ishida Eiichi Taniguchi Tetsuro Hyodo Akira Sasaki Hideo Ando

10.1016/b978-008044799-5/50114-5

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The relationship between SDF-1α/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats

Neurological Research (2009)

Tatsuki Itoh Takao Satou Hiroyuki Ishida Shozo Nishida Masahiro Tsubaki

Objective: The actual relationship between neural stem cells and SDF-1α/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1α (SDF-1α) and its receptor, CXCR4, could contribute to neural stem cells migration after brain injury. In the present study, the temporal relationship between neural stem cells (NSCs) and SDF-1α/CXCR4 around a damaged area was investigated using a rat traumatic brain injury (TBI) model. Methods: We used molecular biology techniques and immunohistochemistry to investigate the relationship between SDF-1α/CXCR4 expression and NSCs existence around a damaged area after TBI in the rat brain. Results: SDF-1α mRNA expression and SDF-1α protein synthesis did not increase after TBI. However, SDF-1α leaked from the injured area and diffused into the cortex 1–3 days after TBI. Subsequently, the levels of CXCR4 mRNA expression and CXCR4 protein synthesis increased significantly. Many small cells with a nestin-positive cytoplasm and fibers also showed immunopositivity for both CXCR4 and SOX-2, but not for GFAP, 3–7 days after TBI. Moreover, a proportion of the CXCR4-positive cells and fibers also showed immunostaining for neurofilaments. Discussion: These results suggest that the leaked SDF-1α attracted CXCR4-positive NSCs as well as elongated nerve fibers. It is considered that the SDF-1α/CXCR4 system in the brain contributes to neural stem cells appearance and maturation after TBI. Therefore, exploitation of the SDF-1α/CXCR4 system around a damaged area may improve the brain dysfunction after TBI.

Nestin

Neurofilament

Immunostaining

10.1179/174313208x332995

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Citations (75)

Retrospective analysis of children with high‐risk acute myeloid leukemia who underwent allogeneic hematopoietic stem cell transplantation following complete remission with initial induction chemotherapy in the AML‐05 clinical trial

Pediatric Blood & Cancer (2019)

Nobuyuki Hyakuna Yoshiko Hashii Hiroyuki Ishida Katsutsugu Umeda Yoshiyuki Takahashi

In the AML-05 clinical trial conducted by the Japanese Pediatric Leukemia/Lymphoma Group from 2006 to 2010, children with high-risk acute myeloid leukemia (HR AML) received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at first complete remission (CR1). The aim of this study was to investigate the impact of allo-HSCT on the outcome of HR AML. Patients with either monosomy 7, 5q-, t(16;21), Ph1, FLT3-ITD, or induction failure after the first course of chemotherapy were eligible for transplant. Of 53 children with HR AML, 51 received allo-HSCT-45 in CR1, five in CR2, and one with non-CR. t(8;21), t(9;11), and t(16;21) abnormalities were identified in eight, five, and four patients, respectively. The stem cell sources varied-bone marrow in 30 patients, peripheral blood in three, and cord blood in 18. The median follow-up was 62 months. The overall survival (OS) rates at 3 years were 73% and 25% for patients who received transplant at CR1 and ≥CR2, respectively. Multivariable analysis showed that patients with chronic graft-versus-host disease (cGVHD) had better OS. This study supports that allo-HSCT is a suitable treatment for HR AML in CR1. The favorable outcome associated with cGVHD indicates that a graft-versus-leukemia effect might be occurring.

Induction chemotherapy

10.1002/pbc.27875

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Citations (13)

Role of platelet-derived chemokines (RANTES and ENA-78) after stem cell transplantation

Transplant Immunology (2006)

Shosaku� Nomura Kazuyoshi� Ishii Shigenori Kanazawa Norihito Inami Yuri Kamitsuji

10.1016/j.trim.2005.12.001

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Citations (21)

Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT

Bone Marrow Transplantation (2012)