Liang-Liang Gao

Northwest University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yuan Guo

Northwest University

Xudong Xu

Institute of Hydrobiology

Xiaoqian Liu

Zhejiang University

Jianjian Zhang

Ministry of Education of the People's Republic of China

Tao Guo

Shaanxi Normal University

Wang Zhi-min

Yunnan University of Traditional Chinese Medicine

Guangwei Wang

Northwest University

Shulin Pang

Northwest University

Hui‐Min Gao

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhimin Wang

Southwest University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Northwest University

Ministry of Education of the People's Republic of China

Shenyang Pharmaceutical University

Chinese Academy of Sciences

State Administration of Traditional Chinese Medicine of the People's Republic of China

Fudan University

China Academy of Chinese Medical Sciences

Beijing Institute of Technology

Qingdao University of Science and Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Three Novel Sterols Isolated from Selaginella tamariscina with Antiproliferative Activity in Leukemia Cells

Planta Medica (2007)

Liang-Liang Gao Shiliang Yin Zhan‐Lin Li Sha Yi Yue‐Hu Pei

Three new sterols, 3β,16α-dihydroxy-5α,17β-cholestan-21-carboxylic acid (1), 3β-acetoxy-16α-hydroxy-5α,17β-cholestan-21-carboxylic acid (2) and 3β-(3-hydroxybutyroxy)-16α-hydroxy-5α,17β-cholestan-21-carboxylic acid (3) were isolated from Selaginella tamariscina (Beauv.) Spring (Selaginellaceae). Their structures were elucidated based on NMR analyses. The growth inhibitory effects and differentiation induction abilities of compounds 1 - 3 were determined in human leukemia HL-60 cells. Compound 1 was more effective than compounds 2 and 3 in inhibiting cell growth, but compound 3 was more effective than compounds 1 and 2 in enhancing induction of all-trans-retinoic acid differentiation.

10.1055/s-2007-981562

Cite

Citations (30)

Isolation of cinnamic acid derivatives from the root of Rheum tanguticum Maxim.ex Balf. and its significance

Journal of Medicinal Plants Research (2012)

Liang-Liang Gao

Eight compounds (1-8) including two naphthalene glycosides, three tannins and three cinnamic acid derivatives were isolated from Rheum tanguticum Maxim.ex Balf. for the first time, except compounds 1, 6, 7 and 8. Their structures were determined mainly by NMR and MS techniques. The result is of significance for comparison and analysis between different rhubarbs by various chromatographic methods. Key words: Rhubarb, Rheum tanguticum, cinnamic acid.

Cinnamic acid

Isolation

10.5897/jmpr11.1497

Cite

Citations (15)

Chemical constituents of the roots of Rheum officinale

Chemistry of Natural Compounds (2013)

Liang-Liang Gao Xudong Xu Junshan Yang

Rheum (plant)

Natural product

10.1007/s10600-013-0689-7

Cite

Citations (27)

Fourier transform mid-infrared spectroscopy (FT-MIR) combined with chemometrics for quantitative analysis of dextrin in Danshen (Salvia miltiorrhiza) granule

Journal of Pharmaceutical and Biomedical Analysis (2015)

Guo Tao Wei-Hong Feng Xiaoqian Liu Hui‐Min Gao Wang Zhi-min

Dextrin

Chemometrics

Excipient

Salvia miltiorrhiza

Granule (geology)

10.1016/j.jpba.2015.11.021

Cite

Citations (25)

Dual-emissive near-infrared fluorogenic probe with enhanced cellular uptake capability for sensitive tracking of cellular polarity

Chinese Chemical Letters (2024)

Xu Qu Baohua Ji Haocheng Gong Guangwei Wang Liang-Liang Gao

Polarity (international relations)

10.1016/j.cclet.2024.110766

Cite

Citations (0)

A Novel Lactam Metabolite from Penicillium sclerotium D35

Chemistry of Natural Compounds (2021)

Tingjiang Liu Chi Gong Jing Zhao D. Dan T. T. Zhang

Lactam

10.1007/s10600-021-03378-y

Cite

Citations (0)

Triterpenoids from Euphorbia maculata and Their Anti-Inflammatory Effects

Molecules (2018)

Yi Sun Liang-Liang Gao Mengyue Tang Baomin Feng Yue‐Hu Pei

Euphorbia maculata is a medicinal plant of the Euphorbiaceae family, which can produce anti-inflammatory and cancer chemopreventive agents of triterpenoids. The present study reports on the bioactive triterpenoids of this plant. Two new lanostane-type triterpenoids, named (3S,4S,7S,9R)-4-methyl-3,7-dihydroxy-7(8→9) abeo-lanost-24(28)-en-8-one (1) and 24-hydroperoxylanost-7,25-dien-3β-ol (2), together with 15 known triterpene derivatives, were isolated from Euphorbia maculata. The structures of the new compounds were determined on the basis of extensive spectroscopic data (UV, MS, ¹H and 13C-NMR, and 2D NMR) analysis. All tetracyclic triterpenoids (1⁻11) were evaluated for their anti-inflammatory effects in the test of TPA-induced inflammation (1 μg/ear) in mice. The triterpenes exhibited significant anti-inflammatory activities.

Euphorbiaceae

Terpene

Anti-inflammatory

Euphorbia

Lanostane

10.3390/molecules23092112

Cite

Citations (32)

Bioactivity-Guided Fractionation of Antioxidative Constituents of Ligustrum lucidum

Chemistry of Natural Compounds (2017)

Liang-Liang Gao Xiaoqian Liu Chun Li Zhimin Wang

10.1007/s10600-017-2046-8

Cite

Citations (4)

Characterization of the Processing of Dry Lily (Lilium davidiiDuch.) Bulbs by Mid-Infrared Spectroscopy

Analytical Letters (2016)

Tao Guo Wei-Hong Feng Xiaoqian Liu Hui‐Min Gao Wang Zhi-min

Sulfur fumigation and blanching have been commonly used to process dry lily bulbs. However, they have several disadvantages; in particular, the former involves health and environmental risks. This study focuses on identifying the processing methods used in dry lily products by mid-infrared spectroscopy. The peak near 1029 cm−1 was red-shifted by 3–6 cm−1, and the intensity of the peak at 1153 cm−1 increased significantly when the lilies were blanched. Furthermore, differences in the processing methods were observed in second derivative infrared spectra. The small shoulder from 1019.0 to 1016.3 cm−1 disappeared after blanching, and the peak shapes from 1030 to 980 cm−1 varied for blanched and unblanched materials. Moreover, the ratio of peak area and peak height at 822 and 667 cm−1 significantly increased following sulfur fumigation. The results show that infrared spectroscopy allows characterization of the processing of dry lily bulbs.

Lilium

10.1080/00032719.2016.1151438

Cite

Citations (1)

Rapid identification and simultaneous analysis of multiple constituents from Rheum tanguticum Maxim. ex Balf. by UPLC/Q-TOF-MS

Natural Product Research (2017)

Liang-Liang Gao Tao Guo Xudong Xu Junshan Yang

Rhubarb contains biologically active compounds such as anthraquinones, anthrones, stilbenes and tannins. A rapid and efficient UPLC/Q-TOF-MS/MS method was developed and applied towards identifying the constituents of Rheum tanguticum Maxim. ex Balf. for the first time. Chemical constituents were separated and investigated by UPLC/Q-TOF-MS/MS in the negative ion mode. The ESI-MS2 fragmentation pathways of four types of compounds were interpreted, providing a very useful guidance for the characterisation of different types of compounds. Based on the exact mass information, fragmentation characteristic and LC retention time of 7 reference standards, 30 constituents were tentatively identified from the methanol extract of R. tanguticum. Among them, seven compounds were described for the first time from R. tanguticum and two from the genus Rheum were described for the first time. The analytical tool used here is valuable for the rapid separation and identification of multiple and minor constituents in methanol extracts of R. tanguticum.

Anthraquinones

Rheum (plant)

Retention time

10.1080/14786419.2017.1280491

Cite

Citations (25)