Maurício José Santos Moreira

Universidade Federal do Rio Grande do Sul

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Lina Naomi Hashizume

Universidade Federal do Rio Grande do Sul

Carolina Schwertner

Universidade Federal do Rio Grande do Sul

Lavínia Schüler‐Faccini

Universidade Federal do Rio Grande do Sul

Clarissa Cavalcanti Fatturi Parolo

Universidade Federal do Rio Grande do Sul

Ana Paula Dall’Onder

Universidade Federal do Rio Grande do Sul

Débora Grando

Universidade Federal do Rio Grande do Sul

Natália Mincato Klaus

Universidade Federal do Rio Grande do Sul

Maria Beatriz Cardoso Ferreira

Universidade Federal do Rio Grande do Sul

Lars Löfqvist

Universidade Federal do Rio Grande do Sul

Clarissa Gewehr Stegues

Universidade Federal do Rio Grande do Sul

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Universidade Federal do Rio Grande do Sul

University of Rio Grande and Rio Grande Community College

Universidade Federal do Rio Grande

Universidade Estadual de Campinas (UNICAMP)

Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina

Université du Québec à Trois-Rivières

University of Gävle

Fundação Faculdade de Odontologia

Hospital de Clínicas de Porto Alegre

University of Pennsylvania

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AVALIAÇÃO DO EFEITO ANTIMICROBIANO DA 8-HIDROXIQUINOLINA EM BACTÉRIAS DE INTERESSE ODONTOLÓGICO – ESTUDO IN VITRO

REVISTA SAÚDE & CIÊNCIA ONLINE (2015)

Thaís de Cássia Negrini Lucas Bozzetti Pigozzi Rafael Morawski Maurício José Santos Moreira Lina Naomi Hashizume

Este estudo teve como objetivo avaliar o efeito da 8-hidroxiquinolina (HQ) contra alguns patogenos envolvidos na carie dentaria e estomatite, como o Streptococcus mutans (SM), Lacobacillus casei (LC) e Candida albicans (CA). Aliquotas de suspensoes padronizadas de cada microrganismo foram uniformemente colocadas em placas de agar de sangue (SM e CA) e Rogosa (LC). Discos de papel filtro esteril com diâmetro padronizado foram impregnados com solucao alcoolica de HQ em diferentes concentracoes (de 40 mg/mL a 0,019 mg/mL) e transferidos para placas de agar. A clorexidina 0,12% (CHX), etanol e agua esterilizada foram utilizados como controles. As placas foram incubadas a 37oC por 24h (CA) ou 48h em condicoes microaerofilas (SM e LC). O diâmetro dos halos de inibicao foi medido com um paquimetro digital e calculou-se a razao entre este diâmetro sobre o diâmetro do papel filtro. Os resultados foram analisados estatisticamente e observou-se que, para SM, o efeito antimicrobiano de HQ em concentracoes de 40 a 5 mg/mL foi estatisticamente superior a CHX. Este efeito foi mais baixo em concentracoes inferiores a 0,31 mg/mL. Para LC, a HQ em concentracoes de 40 a 1,25 mg / mL mostrou efeito semelhante a CHX. Para CA, apenas a HQ na concentracao de 40 mg/mL apresentou melhor efeito em comparacao com a CHX. Pode-se concluir que a HQ tem efeito antimicrobiano contra os agentes patogenicos da cavidade oral, principalmente contra a SM e CA, sendo um composto antimicrobiano promissor na odontologia.

10.35572/rsc.v4i3.273

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Cárie dentária em indivíduos com Síndrome de Down

Maurício José Santos Moreira

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Avaliação in vitro da atividade antimicrobiana de um enxaguatório bucal contendo malva e de seus componentes

Maurício José Santos Moreira

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Guidelines for the proposal of a system of design management indicators in product development companies

Paulo Roberto Nicoletti Dziobczenski Maurício José Santos Moreira Silva Bernardes

The contribution of design to businesses is known, but measuring this result has been a complex task. This paper proposes ways of selecting design management indicators by product development companies. As a method, case studies of companies based in southern Brazil were used. Results show that indicators can be chosen by means of three criteria of selection. In addition, this study presents guidelines to build a system of indicators based on criteria of selection.

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Avaliação das condições de saúde bucal de crianças com síndrome de Down

Maurício José Santos Moreira Carolina Schwertner Clarissa Gewehr Stegues Débora Grando Lavínia Schüler‐Faccini

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Fluoride Availability and Stability in Children's Toothpastes in Uruguay.

PubMed (2017)

Licet Álvarez Loureiro Anunzziatta Fabruccini Maurício José Santos Moreira Marisa Maltz Lina Naomi Hashizume

The purpose of this study was to evaluate the availability and stability of fluoride in children's toothpastes in Uruguay.Six commercial brands of children's toothpaste available in Uruguay were tested. Analyses were made when the dentifrices were purchased (fresh samples) and after one year of storage (aged samples). Total fluoride (TF) and total soluble fluoride (TSF) concentrations were determined using an ion specific electrode.Four of the children's dentifrices showed TF concentration similar to that specified on the package. Three products showed similar concentrations of TF and TSF with no variations after the one-year storage period. Two dentifrices showed an initial insoluble fluoride concentration greater than 50 percent, which increased with toothpaste aging.Most tested toothpastes showed a decrease in the soluble fluoride content with aging. The high quantity of insoluble fluoride found in two tested dentifrices may compromise their anti-caries efficacy.

Dentifrice

Toothpaste

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Salivary secretory IgA concentration and dental caries in children with Down syndrome

Special Care in Dentistry (2017)

Lina Naomi Hashizume Carolina Schwertner Maurício José Santos Moreira Adriana Simon Coitinho Lavínia Schüler‐Faccini

ABSTRACT Purpose To evaluate the relationship between salivary secretory immunoglobulin A (sIgA) concentration and dental caries in children with Down syndrome (DS) and compare it with findings in non‐DS children. Methods The sample comprised 61 DS children and 52 non‐DS children, aged 6 to 14 years. Caries experience, plaque index (PI), and gingival bleeding index (GBI) were recorded. Saliva samples were collected from all children. Total salivary sIgA concentrations were determined using an enzymatic assay method. Results Caries experience in primary and permanent dentitions were similar in DS and non‐DS children. However, PI and GBI values were significantly lower in DS compared to non‐DS children. DS children had higher salivary sIgA concentrations compared to non‐DS children. No difference in sIgA concentration was observed between children with and without caries experience in either group. Conclusions DS children have higher salivary sIgA concentrations than non‐DS children. However, this finding did not correlate with caries experience in the study population.

Secretory IgA

10.1111/scd.12222

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In vitro Antimicrobial Activity of the Components of a Mouthwash Containing Malva sylvestris

Pesquisa Brasileira em Odontopediatria e Clínica Integrada (2012)

Maurício José Santos Moreira Maria Beatriz Cardoso Ferreira Lina Naomi Hashizume

Objetivo: Avaliar a atividade antimicrobiana in vitro dos componentes (tirotricina, quinosol e tintura de malva) de um enxaguatorio bucal contendo malva (Malvatricin®) sobre Streptococcus mutans, Lactobacillus spp. e um pool de micro-organismos da cavidade bucal. Metodo: Para a verificacao do potencial antimicrobiano do enxaguatorio bucal contendo malva (Malvatricin®) e de seus diferentes componentes, a metodologia utilizada foi a da difusao em agar-cilindro em placas. Utilizaram-se dez placas com agar Brain Heart Infusion para cada micro-organismo e foram testadas as seguintes solucoes: Malvatricin®, tirotricina, quinosol e tintura de malva. Como controle positivo foi utilizada uma solucao de clorexidina 0,12%. As placas foram incubadas por 24 horas a 37°C em anaerobiose. Apos 24 horas, mensuraram-se os diâmetros das zonas de inibicao. Utilizou-se o teste de Kruskal-Wallis, seguido pelo teste de comparacoes multiplas, quando indicado, para comparar o efeito de cada substância sobre os micro-organismos testados. O nivel de significância adotado foi de 5%. Resultados: Sobre Streptococcus mutans, Lactobacillus e um pool de micro-organismos da cavidade bucal, Malvatricin® apresentou valores de medianas 23,47; 8,61 e 11,23, respectivamente. O quinosol apresentou resultado semelhante ao de Malvatricin®, mostrando-se efetivo para inibir o crescimento microbiano de todos os micro-organismos (27,17; 9,33; 12,53). A tirotricina (0; 5,66; 0) e a tintura de malva (0; 0; 4,29) apresentaram pouca ou nenhuma atividade antimicrobiana. A clorexidina apresentou as maiores zonas de inibicao frente a todos os micro-organismos testados (30,06; 15,54; 20,89). Conclusao: Os resultados do presente estudo sugerem que, dentre os componentes presentes na composicao do produto comercial Malvatricin®, a substância quinosol apresenta a maior atividade antimicrobiana frente aos micro-organismos testados. E que a atividade antimicrobiana verificada para o produto comercial provavelmente deva-se a acao da substância quinosol, presente em sua composicao.

10.4034/pboci.v12i4.1337

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Genotypic diversity and acidogenicity of Streptococcus mutans in Down syndrome children

Special Care in Dentistry (2019)

Maurício José Santos Moreira Natália Mincato Klaus Ana Paula Dall’Onder Débora Grando Clarissa Cavalcanti Fatturi Parolo

Abstract Aims To evaluate the genotypic diversity and acidogenicity of Streptococcus mutans ( S. mutans ) and the potential association of these factors with dental caries experience in children with DS compared to non‐DS children (controls). Methods and results Seventeen children (age 6‐12 years) with high salivary S. mutans counts (> 2.5 × 10 5 CFU/mL) were selected and divided into two groups: DS and non‐DS. Five children in each group were caries‐free, while the remainder had elevated caries experience. S. mutans isolates were obtained from each participant. The genotypic profile of the isolates was analyzed with the AP‐PCR methodology. The acidogenicity of a representative strain from each genotype of S. mutans was also evaluated. DS children had 16 different S. mutans genotypes, while the control group had 21. Twelve genotypes were present in both groups and one of them was associated with caries‐free status ( P < .05). Although the acidogenicity of the genotypes found in DS children was significantly lower ( P < .05) compared to controls, this fact was not associated with caries experience in both groups. Conclusions DS children have a lower S. mutans genotypic diversity and genotypes with lower acidogenicity than those of non‐DS children. However these findings were not associated with their caries experience.

Early childhood caries

10.1111/scd.12420

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Dental caries and associated factors in twins with Down syndrome: a case report

Special Care in Dentistry (2016)

Maurício José Santos Moreira Carolina Schwertner Ana Paula Dall’Onder Natália Mincato Klaus Clarissa Cavalcanti Fatturi Parolo

ABSTRACT Down syndrome (DS) is the most common genetic disorder in humans, but its incidence in monozygotic twins is extremely rare. The aim of this study was to determine the factors associated with dental caries in a pair of monozygotic twin girls with DS, where one had caries experience and the other did not. Clinical examination, salivary Streptococcus mutans ( S. mutans ) levels and their genotypic diversity, the biochemical composition of the dental biofilm, the frequency of sucrose consumption, and toothbrushing habits were assessed from the twin girls. Twin with caries experience showed higher levels of S. mutans in the saliva and lower concentrations of calcium, phosphate, and fluoride and higher concentrations of extracellular polysaccharides in the biofilm compared to her sister. Genotypic diversity of S. mutans was also higher in the twin with caries experience. Dental biofilm composition showed different patterns of cariogenicity between the two sisters, which may also by itself explain the difference in the dental caries between them.

Dental plaque

10.1111/scd.12213

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