Laurie A. Milner

University of Rochester Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jane L. Liesveld

University of Rochester Medical Center

Michael W. Becker

University of Rochester

Gordon L. Phillips

Atrium Health Wake Forest Baptist

Jonathan W. Friedberg

University of Rochester

Louis S. Constine

University of Rochester Medical Center

Anna Bigas

Centro de Investigación Biomédica en Red de Cáncer

Paul M. Barr

University of Rochester Medical Center

Steven H. Bernstein

Bristol-Myers Squibb (United States)

Ann E. Woolfrey

Fred Hutch Cancer Center

Yuhchyau Chen

University of Rochester

Cooperative Institutions

University of Rochester Medical Center

University of Rochester

Strong Memorial Hospital

Fred Hutch Cancer Center

University of Washington

Seattle University

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Harvard University

Cancer Research Center

Washington University in St. Louis

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

Nature (2000)

Stacey S. Huppert Anh Le Eric H. Schroeter Jeff S. Mumm Meera Saxena

Cell fate determination

Intramembranous ossification

10.1038/35016111

Cite

Citations (323)

Factors associated with outcome after unrelated marrow transplantation for treatment of acute lymphoblastic leukemia in children

Blood (2002)

Ann E. Woolfrey Claudio Anasetti Barry E. Storer K Doney Laurie A. Milner

Cumulative incidence

Total body irradiation

Acute lymphocytic leukemia

10.1182/blood.v99.6.2002

Cite

Citations (126)

Phase I Study of Eltrombopag for Promoting Thrombopoiesis in Patients Undergoing Stem Cell Transplantation After Total Body Irradiation,

Blood (2011)

Jane L. Liesveld Gordon L. Phillips Michael W. Becker Louis S. Constine Jonathan W. Friedberg

Total body irradiation

Eltrombopag

Thrombopoietin receptor

10.1182/blood.v118.21.3295.3295

Cite

Citations (3)

Immunological relationship between β-N-acetylglucosaminidase and Proteinase I from Dictyostelium discoideum

Biochemical and Biophysical Research Communications (1980)

Gary L. Gustafson Laurie A. Milner

Immunoprecipitation

Proteolysis

Slime Mold

Mycetozoa

10.1016/0006-291x(80)90580-x

Cite

Citations (17)

Mapping of human H chain V region genes (VH4) using deletional analysis and pulsed field gel electrophoresis.

The Journal of Immunology (1992)

Ko Willems van Dijk Laurie A. Milner E C Milner

Abstract We have used molecular genetic mapping techniques to establish the order and approximate chromosomal locations of VH4 elements on both chromosomes 14 from a single patient. A total of 10 BglII restriction fragments carrying VH4 elements was characterized. The genomic order of VH4-carrying restriction fragments was determined by analysis of the pattern of loss of hybridizing bands from the genomes of a panel of monoclonal lymphoblastoid cell lines which had well characterized rearrangements of the Ig locus on each chromosome. Some individual elements were identified using sequence-specific oligonucleotide probes. Physical dimensions were estimated by the assignment of these ordered elements to large (50-350-kb) restriction fragments using two-dimensional pulse field gel electrophoresis. Six such fragments spanning approximately 890 kb were physically linked and ordered. The chromosomes differed with respect to the complement of VH4 elements, although no evidence was found of major differences in organization. The establishment of a panel of well characterized deletion lines facilitates the rapid mapping of defined restriction fragments carrying VH elements.

BglII

Restriction fragment

Restriction map

Restriction site

10.4049/jimmunol.148.9.2923

Cite

Citations (12)

Osteoblastic cells regulate the haematopoietic stem cell niche

Nature (2003)

Laura M. Calvi G. B. Adams Kathryn Weibrecht Jonathan M. Weber David P. Olson

10.1038/nature02040

Cite

Citations (3,383)

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

Blood (1999)

Laurie A. Milner Anna Bigas

Mediator

10.1182/blood.v93.8.2431

Cite

Citations (266)

Inhibition of granulocytic differentiation by mNotch1

Proceedings of the National Academy of Sciences (1996)

Laurie A. Milner Anna Bigas Raphael Kopan Carolyn Brashem‐Stein Irwin D. Bernstein

Effective hematopoiesis requires the commitment of pluripotent and multipotent stem cells to distinct differentiation pathways, proliferation and maturation of cells in the various lineages, and preservation of pluripotent progenitors to provide continuous renewal of mature blood cells. While the importance of positive and negative cytokines in regulating proliferation and maturation of hematopoietic cells has been well documented, the factors and molecular processes involved in lineage commitment and self-renewal of multipotent progenitors have not yet been defined. In other developmental systems, cellular interactions mediated by members of the Notch gene family have been shown to influence cell fate determination by multipotent progenitors. We previously described the expression of the human Notch1 homolog, TAN-1 , in immature hematopoietic precursors. We now demonstrate that constitutive expression of the activated intracellular domain of mouse Notch1 in 32D myeloid progenitors inhibits granulocytic differentiation and permits expansion of undifferentiated cells, findings consistent with the known function of Notch in other systems.

Multipotent Stem Cell

10.1073/pnas.93.23.13014

Cite

Citations (180)