Suzana Uzun

University of Zagreb

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Oliver Kozumplik

Klinika za psihijatriju Vrapče

197

Ninoslav Mimica

University of Zagreb

156

Nela Pivac

Rudjer Boskovic Institute

Matea Nikolac Perković

Rudjer Boskovic Institute

Gordana Nedić Erjavec

Rudjer Boskovic Institute

Vera Folnegović-Šmalc

University of Zagreb

DŠ

Dubravka Švob Štrac

Rudjer Boskovic Institute

Lucija Tudor

Rudjer Boskovic Institute

Marcela Konjevod

Rudjer Boskovic Institute

Ivan Požgain

University of Osijek

Cooperative Institutions

University of Zagreb

University Hospital Centre Zagreb

Klinika za psihijatriju Vrapče

Psychiatric Hospital Sveti Ivan

University Psychiatric Hospital

University of Osijek

Rudjer Boskovic Institute

Ministry of Health

University of Mostar

Sisters of Charity Hospital

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Complications in the treatment of patient who took high doses of alprazolam

Suzana Uzun Oliver Kozumplik Klementina Ružić

Bolesnica u dobi od 59 godina, tijekom života nije bila u psihijatrijskom tretmanu. Povremeno bi uzimala alprazolam tablete (ukupno tri tablete dnevno od 0, 5 mg) zadnjih godinu dana. Na pregledu psihijatra kod kojeg se javila zbog problema sa spavanjem negirala je uzimanje bilo kakvih lijekova, a na upite o uzimanju benzodiazepina navodila je da samo povremeno uzme tabletu alprazolama 0, 5 mg. Buduci da je u psihickom statusu dominirala depresivna simptomatila u terapiju je ukljucen fluvoksamin u dnevnoj dozi od 100 mg, uz alprazolam u dnevnoj dozi od 0, 5 mg i zolpidem u vecernjoj dozi od 5 mg. Treceg dana lijecenja bolesnica se javila u bolnicu zbog izražene napetosti, razdražljivosti, tjeskobe, tremora ruku, pojacanog znojenja i problema sa spavanjem. Ucinjena je obrada koja je iskljucila organski supstrat, a bolesnica je potvrdila uzimanje visokih doza alprazolama prije zapocinjanja psihijatrijskog tretmana. Tijekom bolnickog lijecenja doza alprazolama je postupno snižena i potom je alprazolam iskljucen iz terapije. Pri otpustu iz bolnice bolesnici je preporuceno da u terapiji dalje uzima fluvoksamin u vecernjoj dozi od 100 mg, uz zolpidem u vecernjoj dozi od 10 mg.

Alprazolam

Zolpidem

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Analiza posterske aktivnosti do kraja 2006. godine u svrhu sagledavanja stručno-znanstvene aktivnosti u Psihijatrijskoj bolnici Vrapče

Socijalna psihijatrija (2024)

Ninoslav Mimica Suzana Uzun Oliver Kozumplik Nikola Žaja Tamara Sabo

10.24869/spsih.2024.83

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The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder

International Journal of Molecular Sciences (2023)

Lucija Tudor Gordana Nedić Erjavec Matea Nikolac Perković Marcela Konjevod Suzana Uzun

The molecular underpinnings of post-traumatic stress disorder (PTSD) are still unclear due to the complex interactions of genetic, psychological, and environmental factors. Glycosylation is a common post-translational modification of proteins, and different pathophysiological states, such as inflammation, autoimmune diseases, and mental disorders including PTSD, show altered N-glycome. Fucosyltransferase 8 (FUT8) is the enzyme that catalyzes the addition of core fucose on glycoproteins, and mutations in the FUT8 gene are associated with defects in glycosylation and functional abnormalities. This is the first study that investigated the associations of plasma N-glycan levels with FUT8-related rs6573604, rs11621121, rs10483776, and rs4073416 polymorphisms and their haplotypes in 541 PTSD patients and control participants. The results demonstrated that the rs6573604 T allele was more frequent in the PTSD than in the control participants. Significant associations of plasma N-glycan levels with PTSD and FUT8-related polymorphisms were observed. We also detected associations of rs11621121 and rs10483776 polymorphisms and their haplotypes with plasma levels of specific N-glycan species in both the control and PTSD groups. In carriers of different rs6573604 and rs4073416 genotypes and alleles, differences in plasma N-glycan levels were only found in the control group. These molecular findings suggest a possible regulatory role of FUT8-related polymorphisms in glycosylation, the alternations of which could partially explain the development and clinical manifestation of PTSD.

Fucosyltransferase

Glycome

10.3390/ijms24065706

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Clinical trial going on for 10 years - how is it possible?

Psychiatria Danubina (2009)

Ninoslav Mimica Vera Folnegović-Šmalc Suzana Uzun Oliver Kozumplik

In this short text a number of conditions which should be obtained and achieved are discussed, all in purpose to maintain the clinical trial for 10 years or more.

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Patients with catatonic schizophrenia do not have better prognsis then patients with paranoid schizophrenia

Schizophrenia Research (2012)

Ninoslav Mimica Vera Folnegović-Šmalc Suzana Uzun Oliver Kozumplik

Paranoid schizophrenia

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Metabolomic and glycomic findings in posttraumatic stress disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2018)

Marcela Konjevod Lucija Tudor Dubravka Švob Štrac Gordana Nedić Erjavec Coral Barbas

Metabolome

Glycomics

Omics

Glycome

10.1016/j.pnpbp.2018.07.014

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Citations (44)

Od Konferencije o demencijama do CROCAD-14

Ninoslav Mimica Goran Šimić Morana Ivičić Suzana Uzun Oliver Kozumplik

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Treatment with haloperidol and changes in glucose values in patients with schizophrenia

Oliver Kozumplik Suzana Uzun Ninoslav Mimica Miro Jakovljević

Results: Patient, 39 years old, with diagnosis of schizophrenia, was in psychiatric treatment for the past 20 years. The patient's compli-ance with previous oral antipsychotic therapy was poor and for that reason she was treated with haloperidol depot during period of 5 years. The patient occasionally had ideas of reference, but with such treatment she was able to function in her social activities and at work. At control examination, the patient reported often being thirsty and also reported frequent urination. The laboratory exami-nation and examination of specialist of internal medicine were advised. Results of laboratory examination showed glucose value above the reference range. In the same time, there was no change in patient's body weight. Also, there was no change in patient's diet. Treatment with haloperidol was discontinued and treatment with fluphenazine was initiated, again as depot injection, because of poor compliance with oral antipsychotic therapy. The patient responded well to such therapy, she was able to function in her social activities and at work, and values of glucose gradually returned to previous values (within reference range).Conclusion: Laboratory examination showed glucose value above the reference range in the patient who was treated with haloperidol depot ; after switching to fluphenazine depot values of glucose gradually returned to previous values (within reference range). Policy of full disclosure: None.

Fluphenazine

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Clonazepam augmentation during treatment with antipsychotics in aggressive psychiatric inpatients - pilot study

Medica Jadertina (2018)

Ninoslav Mimica Suzana Uzun Gordan Makarić Oliver Kozumplik Tajana Ljubin Golub

Clonazepam

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Postupanje zdravstvenog osoblja prema osobama starije životne dobi

Senka Repovečki Krešimir Radić Suzana Uzun Jasminka Bektić Hodžić Marija Kušan Jukić

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