ИА

И. А. Ботвиньева

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ЛВ

Л. В. Ренге

Kemerovo State Medical Academy

ЛГ

Л. Г. Баженова

Kemerovo State Medical Academy

ИА

И. А. Панина

МП

М. П. Корф

ЕВ

Елена Владимировна Осипова

The First Republican Clinical Hospital of the Ministry of Health of the Udmurt Republic

ЛН

Л. Н. Колбасин

Autonomous Healthcare

НИ

Н. И. Кононенко

Kursk Regional Clinical Oncology Center

НЕ

Н. Е. Павленко

ОН

О. Н. Давыдова

ВБ

В. Б. Веледницкий

Cooperative Institutions

Ministry of Health of the Russian Federation

Research Centre for Medical Genetics

Russian Academy of Sciences

Russian Medical Academy of Continuous Professional Education

Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan

Novokuznetsk State Institute of Advanced Medical Education

Federal Medical-Biological Agency

Kazan State Medical Academy

Tver State Technical University

Research Institute of Medical Genetics of Russian Academy of Medical Sciences

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Белки острой фазы воспаления в прогнозе состояния новорожденного при беременности, осложненной многоводием, и при риске внутриутробной инфекции

Клиническая лабораторная диагностика (2012)

И. А. Ботвиньева Л. В. Ренге Zorina Rm Л. Г. Баженова В. Н. Зорина

The content of a-macroglobulin associated with pregnancy, a2-glycoprotein, a1-antitripsin, and lactoferrin in blood serum of pregnant women and umbilical serum under hydramnion and risk of development of intrauterine infection of fetus is in-vestigated. It is demonstrated that in case of presence in blood of pregnant woman of G-antibodies to C. trachomatis under low titers (1:20, 1:40) the increase of lev-els of a-macroglobulin, a2-glycoprotein, a1-antitripsin and especially of lactoferrin in serum of pregnant women testifies the high risk of presence of intrauterine in-fection of fetus and probability of birth of child with low values on Apgar scale.

Lactoferrin

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АУДИТ РАННЕГО ПРЕНАТАЛЬНОГО СКРИНИНГА В СУБЪЕКТАХ РОССИЙСКОЙ ФЕДЕРАЦИИ. ЧАСТЬ 2. РЕСПУБЛИКА АДЫГЕЯ — ЯРОСЛАВСКАЯ ОБЛАСТЬ

Медицинская генетика (2015)

Л. А. Жученко П. А. Голошубов Е. Н. Андреева Е. А. Калашникова Е В Юдина

Early combined prenatal screening for frequent chromosomal abnormalities and congenital disorders was organized in the Russian Federation in 2010 on the initiative of the Ministry of Health and Social Development and with the support of the Government of the Russian Federation in accordance with FMF guidelines. The first results achieved in the implementation of the activities of new screening model, and the evaluation of key indicators and the general condition of the early prenatal screening in the regions and the federal districts of Russia are presented.

Christian ministry

10.1234/xxxx-xxxx-2014-8-3-60

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Хламидийная инфекция у беременных Юга Кузбасса

Вестник Российского университета дружбы народов. Серия: Медицина (2012)

Л. Г. Баженова В. Н. Зорина Л. В. Ренге И. А. Ботвиньева Андрей Николаевич Полукаров

Prevalence of antibodies IgG to Ch. trachomatis was researched into among 15 000 pregnant women of South of Kuzbass during 5 years, estimation of efficiency of additional testing by method of immunoenzyme analysis of levels of IgG antibodies to MOMP+pgp3, Hsp60 in blood of pregnant women with antibodies to Ch. trachomatis and symptoms of fetoplacental failure was carried out. It is revealed that antibodies were detected among 38,5% of pregnant women in 2011 and it is by 22,1% higher than in 2007, due to more revealing of pregnant women with a low titre (1:5-1:10). The research confirmed the efficiency of diagnosis chlamydial infection only with help of estimation titre IgG to Chlamydia trachomatis and showed that only a part of pregnant women, carrying antibodies to Ch. trachomatis and having antibodies to Hsp60, need a specific antibiotic therapy to take preventive measures against development of intrauterine infection. This diagnostic approach to estimation of risks in infection of a fetus of pregnant women carrying antibodies to Ch. trachomatis can be recommended to obstetriciangynecologists and neonatologists.

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АУДИТ РАННЕГО ПРЕНАТАЛЬНОГО СКРИНИНГА В СУБЪЕКТАХ РОССИЙСКОЙ ФЕДЕРАЦИИ.ЧАСТЬ 1. АЛТАЙСКИЙ КРАЙ — ПЕРМСКИЙ КРАЙ

Медицинская генетика (2015)

Л. А. Жученко П. А. Голошубов Е. Н. Андреева Е. А. Калашникова Е В Юдина

Christian ministry

10.1234/xxxx-xxxx-2014-7-3-51

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CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION

Medical Immunology (Russia) (2014)

И. А. Ботвиньева Л. В. Ренге V. N. Zorina R. M. Zorina Андрей Николаевич Полукаров

We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cord blood sera, obtained at delivery. We had found high levels of TNFα, IL-6, IL-8, IL-10 in sera from umbilical cord blood, and increased levels of TNFα in maternal sera before delivery in a group of women with high Apgar scores of their children (≥ 8 points), in comparison with control group. High levels of TNFα, IL-6, IL-10 in sera from umbical cord and increased serum concentrations of IL-6, IL-10, IL-1ra and TNFα before delivery were evaluated in group of women with circulating antibodies against C. trachomatis during pregnancy and with low degrees of newborn children (< 7 by Apgar score). We suggest that high cytokine levels in maternal blood and in sera of umbilical cord blood from women with polyhydramnios and circulating antibodies against C. trachomatis sufficiently correlate with high clinical risk of intrauterine infection in newborns. However, high inter-individual variability of the cytokine parameters does not permit their usage as independent diagnostic criteria.

Cord blood

Apgar score

10.15789/1563-0625-2013-3-277-282

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Риски репродуктивного здоровья женщины: проектный подход и здоровьесберегающие технологии

Medical Almanac (2013)

I.I. Stolnikova Елена Александровна Евстифеева Елена Владимировна Борисова С.И. Филиппченкова И. А. Ботвиньева

The interdisciplinary project of modern medico-psychological approaches and economic calculations for preservation of reproductive function of the woman, allowing to understand her motives and expectations concerning undesirable pregnancy and through reflexive technologies is submitted to stimulate it to adoption of the correct decision in case of the prevention of pregnancy and arising risks of loss of function of a child-bearing.

Reflexivity

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