Philip R. Cohen

Touro University California

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Sharon Oviatt

Monash University

David R. McGee

Bellevue College

Razelle Kurzrock

University of California, San Diego

Hector J. Levesque

University of Toronto

Martha E. Pollack

University of Pittsburgh

Sanjeev Kumar

TU Dresden

Jerry L. Morgan

Denver Health Medical Center

Ryan R Riahi

DermSurgery Associates

Ira Smith

Oregon Health & Science University

Marcus J. Huber

General Motors (United States)

Cooperative Institutions

Howard Hughes Medical Institute

University of California, San Diego

Harvard University

National Institutes of Health

The University of Texas MD Anderson Cancer Center

University of Washington

University of North Carolina at Chapel Hill

Stanford University

Columbia University

University of Toronto

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Data from Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade

Natalie Galanina Aaron M. Goodman Philip R. Cohen Garrett M. Frampton Razelle Kurzrock

<div>AbstractKaposi sarcoma (KS) is an incurable, human immunodeficiency virus (HIV)-associated malignancy. We reviewed 320 immunotherapy-treated patient records. Seventeen had HIV-associated malignancies, including nine men with KS. Median viral load was 20 copies/mL (range, undetectable to 549,704) and median CD4 count was 256 cells/μL (range, 10–603). Eight patients received nivolumab and one received pembrolizumab. Six patients (67%) achieved partial (N = 5) or complete remission (N = 1). No drug-related grade >2 toxicities occurred. In seven patients, CD4 counts increased (P = 0.09). Tissue and/or blood-derived circulating tumor DNA (ctDNA) was evaluated by next-generation sequencing. Four evaluable patients each showed anomalies in distinct genes: TP53, KRAS, TLL2, PTPN6 (tissue and/or ctDNA), and NF1 (ctDNA). Tumor mutational burden was low, and PD-L1 immunohistochemistry was negative (three and four assessable patients, respectively). Responders included patients with low CD4 counts, high HIV load, and/or visceral disease. In summary, checkpoint blockade demonstrated significant antitumor activity and low toxicity in patients with HIV-associated KS. Cancer Immunol Res; 6(10); 1129–35. ©2018 AACR.</div>

Immune checkpoint

10.1158/2326-6066.c.6548191

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Genodermatoses with malignant potential.

PubMed (1992)

Philip R. Cohen

Disease-associated malignancy may occur in several inherited conditions with dermatologic manifestations. These genodermatoses include nevoid basal cell carcinoma syndrome, Cowden's disease, multiple endocrine neoplasia syndromes, neurofibromatosis and Peutz-Jeghers syndrome. Although most of these genodermatoses are rare, recognition of their cutaneous features can facilitate early diagnosis of the systemic condition and surveillance for neoplasm. Appropriate evaluation of the patient's family, as well as genetic counseling, should be performed when the diagnosis of a genodermatosis with malignant potential is established.

Genodermatosis

Peutz–Jeghers syndrome

Cowden syndrome

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Picture of the Month

Archives of Pediatrics and Adolescent Medicine (1988)

Philip R. Cohen

10.1001/archpedi.1988.02150070099036

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The role of voice in human-machine communication

National Academy Press eBooks (1994)

Philip R. Cohen Sharon Oviatt

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Multiple skin neoplasms at one site (MUSK IN A NEST): collision tumor consisting of epidermal (macular seborrheic keratosis) and dermal (lichen amyloidosis) components

Dermatology Online Journal (2022)

Jennifer Laborada Christof P Erickson Antoanella Calame Philip R. Cohen

A collision tumor is a neoplastic lesion comprised of two or more tumors consisting of distinct cell populations in the concurrent location. Multiple skin neoplasms at one site (MUSK IN A NEST) is a term recently coined to describe two or more cutaneous benign or malignant tumors occurring at the same anatomic site. In retrospective studies, seborrheic keratosis and cutaneous amyloidosis have both individually been documented as a component of a MUSK IN A NEST. This report describes a 42-year-old woman who presented with a pruritic skin condition on her arms and legs of 13 years' duration. Skin biopsy results showed epidermal hyperplasia with hyperkeratosis, hyperpigmentation of the basal layer with mild acanthosis, and evidence of amyloid deposition in the papillary dermis. Based on the clinical presentation and pathology findings, a concurrent diagnosis of macular seborrheic keratosis and lichen amyloidosis was established. A MUSK IN A NEST consisting of a macular seborrheic keratosis and lichen amyloidosis is likely a more common occurrence than implied by the paucity of published cases of this phenomenon.

Seborrheic keratosis

Acanthosis

Keratosis

10.5070/d328559259

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Spoken language in interpreted telephone dialogues

Computer Speech & Language (1992)

Sharon Oviatt Philip R. Cohen

Chunking (psychology)

Indirection

Spoken Language

Exploratory research

10.1016/0885-2308(92)90021-u

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Citations (45)

Referring as a Collaborative Process

Philip R. Cohen Jerry Morgan Martha E. Pollack

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Intention = choice + commitment

National Conference on Artificial Intelligence (1987)

Philip R. Cohen Hector J. Levesque

This paper provides a logical analysis of the concept of intention as composed of two more basic concepts, choice (or goal) and commitment. By making explicit the conditions under which an agent can drop her goals, i.e., by specifying how the agent is committed to her goals, the formalism provides analyses for Bratman's three characteristic functional roles played by intentions [Bratman, 1986], and shows how agents can avoid intending all the foreseen side-effects of what they actually intend. Finally, the analysis shows how intentions can be adopted relative to a background of relevant beliefs and other intentions or goals. By relativizing one agent's intentions in terms of beliefs about another agent's intentions (or beliefs), we derive a preliminary account of interpersonal commitments.

Formalism (music)

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The efficiency of multimodal interaction for a map-based task

Philip R. Cohen David R. McGee Josh Clow

This paper compares the efficiency of using a standard direct-manipulation graphical user interface (GUI) with that of using the QuickSet pen/voice multimodal interface for supporting a military task. In this task, a user places military units and control measures (e.g., various types of lines, obstacles, objectives) on a map. Four military personnel designed and entered their own simulation scenarios via both interfaces. Analyses revealed that the multimodal interface led to an average 3.5-fold speed improvement in the average entity creation time, including all error handling. The mean time to repair errors also was 4.3 times faster when interacting multimodally. Finally, all subjects reported a strong preference for multimodal interaction. These results indicate a substantial efficiency advantage for multimodal over GUI-based interaction during map-based tasks.

Interface (matter)

Multimodal Interaction

Graphical user interface

Task Analysis

10.3115/974147.974193

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Citations (43)

Representing and executing protocols as joint actions

Sanjeev Kumar Marcus J. Huber Philip R. Cohen

Families of conversation protocols can be expressed formally as partially ordered landmarks where the landmarks represent the state of affairs that must be brought about during the goal-directed execution of a protocol. Then, concrete protocols represented as joint action expressions can be derived from the partially ordered landmarks and executed directly by joint intention interpreters, thus nearly eliminating the need to implement a separate protocol handling system. This approach also supports (1) flexibility in the actions used to achieve landmarks, (2) shortcutting protocol execution, and (3) application of the joint intention theory to provide automatic exception handling along with a correctness criterion for protocols.

10.1145/544862.544869

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Citations (30)