Kateřina Sheardová

St. Anne's University Hospital Brno

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Jakub Hort

St. Anne's University Hospital Brno

Martin Vyhnálek

St. Anne's University Hospital Brno

Jan Laczó

Charles University

Ross Andel

Arizona State University

Zuzana Nedelská

Charles University

Irena Rektorová

Masaryk University

Kamil Vlček

Czech Academy of Sciences, Institute of Physiology

Ivana Gažová

Charles University

Rafał Marciniak

St. Anne's University Hospital Brno

Hana Marková

Charles University

Cooperative Institutions

St. Anne's University Hospital Brno

University Hospital Brno

Masaryk University

Charles University

International Clinical Research Center, St. Anne's University Hospital Brno

University Hospital in Motol

Inserm

Karolinska Institutet

Harvard University

Universitat Autònoma de Barcelona

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Emotional prosody recognition is impaired in Alzheimer’s disease

Alzheimer s Research & Therapy (2022)

Jana Amlerová Jan Laczó Zuzana Nedelská Martina Laczó Martin Vyhnálek

Abstract Background The ability to understand emotions is often disturbed in patients with cognitive impairments. Right temporal lobe structures play a crucial role in emotional processing, especially the amygdala, temporal pole (TP), superior temporal sulcus (STS), and anterior cingulate (AC). Those regions are affected in early stages of Alzheimer´s disease (AD). The aim of our study was to evaluate emotional prosody recognition (EPR) in participants with amnestic mild cognitive impairment (aMCI) due to AD, AD dementia patients, and cognitively healthy controls and to measure volumes or thickness of the brain structures involved in this process. In addition, we correlated EPR score to cognitive impairment as measured by MMSE. The receiver operating characteristic (ROC) analysis was used to assess the ability of EPR tests to differentiate the control group from the aMCI and dementia groups. Methods Eighty-nine participants from the Czech Brain Aging Study: 43 aMCI due to AD, 36 AD dementia, and 23 controls, underwent Prosody Emotional Recognition Test. This experimental test included the playback of 25 sentences with neutral meaning each recorded with different emotional prosody (happiness, sadness, fear, disgust, anger). Volume of the amygdala and thickness of the TP, STS, and rostral and caudal parts of AC (RAC and CAC) were measured using FreeSurfer algorithm software. ANCOVA was used to evaluate EPR score differences. ROC analysis was used to assess the ability of EPR test to differentiate the control group from the aMCI and dementia groups. The Pearson’s correlation coefficients were calculated to explore relationships between EPR scores, structural brain measures, and MMSE. Results EPR was lower in the dementia and aMCI groups compared with controls. EPR total score had high sensitivity in distinguishing between not only controls and patients, but also controls and aMCI, controls and dementia, and aMCI and dementia. EPR decreased with disease severity as it correlated with MMSE. There was a significant positive correlation of EPR and thickness of the right TP, STS, and bilateral RAC. Conclusions EPR is impaired in AD dementia and aMCI due to AD. These data suggest that the broad range of AD symptoms may include specific deficits in the emotional sphere which further complicate the patient’s quality of life.

Emotional prosody

10.1186/s13195-022-00989-7

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Diagnostikujeme a léčíme demence správně a včas? Výsledky průzkumu ve světle nových doporučení

Psychiatrie pro praxi (2012)

Martin Vyhnálek Aleš Bartoš Václav Dostál Vanda Franková Iva Holmerová

10Neurologicke odděleni, Pardubicka krajska nemocnice, Pardubice 11Centrum klinických neurověd, Neurologicka klinika 1. LF UK a VFN, Praha 12Neurologicka klinika, LF UK a FN Hradec Kralove 13Výzkumna skupina Aplikovane neurovědy, CEITEC MU, Brno 14Psychiatricka lecebna Dobřany Průzkum mezi 150 ambulantnimi neurology, psychiatry a geriatry zjisťoval aktualni zvyklosti v diagnostice a lecbě kognitivnich poruch v CR. Vice než polovina pacientů s kognitivni poruchou byla diagnostikovana až ve středně pokrocilem a pozdnim stadiu. Výsledky ukazuji nedostatecne uživani zobrazovacich metod v diagnostice. Větsina pacientů s diagnozou Alzheimerovy choroby je lecena kognitivy. Potvrzuje se siroke uživani neucinných nootropik.

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THE RELATIONSHIP BETWEEN LIVING ALONE AND STRESS FROM A LIFE COURSE PERSPECTIVE

Innovation in Aging (2024)

Junyub Lim Ross Andel Kateřina Sheardová John V. Pavlik Jana Amlerová

Abstract Background/objectives Social isolation may affect psychological well-being, but understanding this link across adulthood is limited. We examined living alone in relation to dealing with daily stress among younger, middle-aged, and older adults. Methods Data from Terrapino, a new mobile application designed to support cognitive health, were utilized. Psychological well-being was assessed with a 10-item index of dealing with daily stress over the past month (get angry, feel like things are piling up, feel like being on top of things, etc.) reported as never/sometimes/often/very often. Demographic, health, and lifestyle information was also collected. Results Complete data were available for 6,154 users who gave consent to allow reports of aggregate data (mean=57.2±14.4, range 18-103 years, 73% were female). Users were categorized as young (18-30 years, n=331), middle-aged (31-60 years, n=3,058), and older (61+ years, n=2,765) adults, of whom 45% (52% male/42% female), 20% (17% male/21% female), and 32% (15% male/39% female) young, middle-aged, and older adults, respectively, lived alone. Controlling for sex, education, and comorbidity, young adults who lived alone had poorer ability to deal with daily stress (Estimate=0.22, p<.05), no differences existed among middle-aged adults (p>.05) and better ability to deal with daily stress emerged among older adults living alone (Estimate=-0.11, p<.01). Discussion Using data from a freely available mobile application, young users who lived alone dealt with daily stress relatively poorly, whereas their older counterparts showed opposite trends regardless of comorbidity. This study sets the stage for research into mobile application use to improve well-being of older adults living alone.

Life course approach

Course (navigation)

10.1093/geroni/igae098.3752

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Answer to Letter to the Editor: Vascular risk factors do not contribute to motor and cognitive impairment in Parkinson's Disease by Dr Sławek et al.

Parkinsonism & Related Disorders (2009)

Ivan Rektor David Goldemund Kateřina Sheardová Irena Rektorová Zuzana Michálková

10.1016/j.parkreldis.2009.07.004

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Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

Alzheimer s & Dementia (2023)

Mária Čarná Isaac G. Onyango Stanislav Katina Dušan Holub Jan Novotný

The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD. HIGHLIGHTS: Cerebrospinal fluid changes associated with aging are perturbed in Alzheimer's disease Paradoxically, in Alzheimer's disease, the choroid plexus exhibits increased cytokine levels without evidence of inflammatory activation or infiltrates In Alzheimer's disease, increased choroid plexus volumes correlate with age and cognitive performance.

Pathogenesis

Choroid

10.1002/alz.12970

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Hyperintenzivní léze reagující na steroidy u pacienta sCreutzfeldt-Jakobovou nemocí

Česká a slovenská neurologie a neurochirurgie (2010)

Kateřina Sheardová R. Matěj Irena Rektorová

Hyperintenzivni leze reagujici na steroidy u pacienta s Creutzfeldt-Jakobovou nemoci - leze bile hmoty u CJD castecně ustoupily po aplikaci kortikosteroidů přes klinickou progresi onemocněni.

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Biomarker counseling, disclosure of diagnosis, and follow‐up in patients with mild cognitive impairment: A European survey of EADC centers

Alzheimer s & Dementia (2020)

Kristian Steen Frederiksen Rune Nielsen David J. Robinson Lucrezia Hausner Bernard Hanseeuw

Abstract Background The concept of mild cognitive impairment (MCI) was developed as a research to capture a group of patients with objectively measurable cognitive impairment not fulfilling the criteria for dementia but has since diffused into clinical practice in many centers. The objective of the present survey was to assess practices with regards to diagnostic procedure and disclosure including biomarker counselling and management in patients with MCI. Methods The present study was designed as an online survey of medical doctors working in European Alzheimer Disease Centers (EADC). Results A total of 34 center coordinating doctors out of 41 (80.9 %) and 110 out of 213 (50.6 %) individual doctors responded to the survey. Almost all respondents had access to MRI (98.2%; n=108) and CSF sampling (91.8%; n=101), whereas fewer had access to 18F‐FDG‐PET (74.5%; n=82) and amyloid PET (50.9%; n=56). Most, but not all respondents, always or usually discussed the decision to order biomarkers with patients with MCI (85.7%; n=90) and dementia (81.1 %; n=86). Nearly half (49.5 % n=54) of respondents found that the diagnosis of MCI was meaningful to a great extent, whereas this was 75.5 % (n=84) for dementia (z=3.77; p=0.0002). Almost all respondents reported always or usually following up MCI (95.2%; n=100) and dementia patients (90.48%; n=95). Half (50.5%; n=53) of respondents reported following MCI patients for 5 or more years and for dementia 45.3% (n=48). Conclusion We found that biomarkers are widely used in patients with MCI, but that not all patients receive adequate pre and post biomarker counselling. For a considerable proportion of practices, we found considerable variability across centers. This may indicate that clinicians lack guidance on issues related to diagnostic disclosure including biomarker sampling.

10.1002/alz.039026

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The effect of physiological aging on spatial navigation in a computerized human analog of the Morris Water Maze

Journal of the Neurological Sciences (2013)

Ivana Gažová Jan Laczó Ivana Mokrišová Kateřina Sheardová Jakub Hort

Water maze

10.1016/j.jns.2013.07.1196

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Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer’s disease and three sex- and age-matched healthy controls

Stem Cell Research (2021)

Jan Raška Hana Klímová Kateřina Sheardová Veronika Fedorová Hana Hříbková

Human induced pluripotent stem cell (iPSC) lines were generated from patients with spontaneous late-onset Alzheimer's disease (AD) and three healthy control individuals. Peripheral blood mononuclear cells were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer's disease in vitro.

10.1016/j.scr.2021.102378

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P059: Influence of perceived social support on cognitive decline in rural community-dwelling seniors

European Geriatric Medicine (2014)

Daniel Hudeček Kateřina Sheardová Jakub Hort

Rural community

Cognitive Decline

10.1016/s1878-7649(14)70234-7

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