Luana B. Xavier

Universidade Federal de Minas Gerais

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Fernando M. Reis

Universidade Federal de Minas Gerais

Iêda de Fátima Oliveira Silva

Universidade Federal de Minas Gerais

Ana Lúcia Cândido

Universidade Federal de Minas Gerais

Karina Braga Gomes

Universidade Federal de Minas Gerais

Cláudia N. Ferreira

University of Haifa

Daisy K. D. de Oliveira

Universidade Federal de Minas Gerais

Mariana F. Sales

Universidade Federal de Minas Gerais

Kathryna Fontana Rodrigues

Universidade Federal de Minas Gerais

Josianne Nicácio Silveira

Universidade Federal de Minas Gerais

Kathryna F. Rodrigues

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

Centro Universitário de Belo Horizonte

Rathenau Instituut

Hospital das Clínicas da Universidade Federal de Minas Gerais

Catholic University of Angola

University of Siena

Institut Cochin

Université Paris Cité

Inserm

Universidade Estadual de Feira de Santana

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Evaluation of PCSK9 levels and its genetic polymorphisms in women with polycystic ovary syndrome

Gene (2017)

Luana B. Xavier Mirelle O. Sóter Mariana F. Sales Daisy K. D. de Oliveira Helton José Reis

PCSK9

Dyslipidemia

Proprotein Convertases

Lipid Profile

Kexin

10.1016/j.gene.2017.11.006

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Citations (21)

Polymorphisms in vitamin D receptor gene, but not vitamin D levels, are associated with polycystic ovary syndrome in Brazilian women

Gynecological Endocrinology (2018)

Luana B. Xavier Natália Alves Gontijo Kathryna Fontana Rodrigues Ana Lúcia Cândido Fernando M. Reis

This study aimed to investigate the association between vitamin D (VitD) levels, polymorphisms in VDR gene (ApaI, BsmI, FokI, and TaqI) and the polycystic ovary syndrome (PCOS) in a group of Brazilian women. A total of 100 patients with PCOS and 100 control women were included. The quantification of 25-hydroxyvitamin D (25(OH)D) was performed in high-performance liquid chromatography (HPLC). Polymorphisms on VDR gene were performed by PCR-RFLP. The BsmI AG genotype was more frequent in PCOS group, while the GG genotype was more frequent in the control group (p = .007). The frequency of the Taql CC genotype was higher in PCOS group, while the CT genotype was the most frequent in the control group (p = .021). Mean serum VitD levels were similar between the groups. However, there was a negative correlation between VitD levels and Ferriman-Gallwey score (p = .031, r = −.260) in the PCOS group. The TaqI and BsmI polymorphisms were associated with PCOS. Moreover, VitD levels are associated with the clinical hyperandrogenism. The data suggest the role of VitD in PCOS development and its complications.

FokI

TaqI

Hyperandrogenism

10.1080/09513590.2018.1512966

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Citations (26)

Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome

Journal of Assisted Reproduction and Genetics (2017)

Laura Machado Lara Carvalho Cláudia N. Ferreira Daisy K. D. de Oliveira Kathryna F. Rodrigues Rita Carolina Figueiredo Duarte

Haptoglobin

Pathogenesis

Lipid Profile

10.1007/s10815-017-1030-3

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Citations (16)