Min Xiong

Guangzhou Medical University

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Yue Lü

Beijing Dao Pei Hospital

Yanli Zhao

Kunming University of Science and Technology

Zhijie Wei

Beijing Dao Pei Hospital

Deyan Liu

Beijing Dao Pei Hospital

Ruijuan Sun

Beijing Dao Pei Hospital

Jia-Rui Zhou

Beijing Dao Pei Hospital

Xingyu Cao

Beijing Dao Pei Hospital

Dao‐Pei Lu

Beijing Dao Pei Hospital

Zhentao Zhang

Wuhan University

Hongxing Liu

Hebei Medical University

Cooperative Institutions

Huazhong University of Science and Technology

Wuhan University

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Renmin Hospital of Wuhan University

Sichuan University

Sun Yat-sen University

Shanghai Jiao Tong University

Peking University

Central South University

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Efficacy and Safety of CD28- or 4-1BB-Based CD19 CAR-T Cells in B Cell Acute Lymphoblastic Leukemia

Molecular Therapy — Oncolytics (2020)

Xiangyu Zhao Junfang Yang Xian Zhang Xin‐an Lu Min Xiong

CD19-directed chimeric antigen receptor-T (CAR-T) cells with a 4-1BB or CD28 co-stimulatory domain have shown impressive antitumor activity against relapsed or refractory B cell acute lymphoblastic leukemia (r/r B-ALL). However, a parallel comparison of their performances in r/r B-ALL therapy has not been sufficiently reported. Here, we manufactured 4-1BB- and CD28-based CD19 CAR-T cells using the same process technology and evaluated their efficacy and safety in r/r B-ALL therapy based on pre-clinical and exploratory clinical investigations. In B-ALL-bearing mice, a similar antitumor effect and CAR-T kinetics in peripheral blood were observed at the CAR-T dose of 1 × 107/mouse. However, when the dose was decreased to 1 × 106/mouse, 4-1BB CAR-T cells were more potent in eradicating tumor cells and showed longer persistence than CD28 CAR-T cells. Retrospective analysis of an exploratory clinical study that used 4-1BB- or CD28-based CAR-T cells to treat r/r B-ALL was performed. Compared with CD28 CAR-T cells, 4-1BB CAR-T cells resulted in higher antitumor efficacy and less severe adverse events. This study demonstrated that the performance of 4-1BB CAR-T cells was superior to that of CD28 CAR-T cells in suppressing CD19+ B-ALL, at least under our manufacturing process. CD19-directed chimeric antigen receptor-T (CAR-T) cells with a 4-1BB or CD28 co-stimulatory domain have shown impressive antitumor activity against relapsed or refractory B cell acute lymphoblastic leukemia (r/r B-ALL). However, a parallel comparison of their performances in r/r B-ALL therapy has not been sufficiently reported. Here, we manufactured 4-1BB- and CD28-based CD19 CAR-T cells using the same process technology and evaluated their efficacy and safety in r/r B-ALL therapy based on pre-clinical and exploratory clinical investigations. In B-ALL-bearing mice, a similar antitumor effect and CAR-T kinetics in peripheral blood were observed at the CAR-T dose of 1 × 107/mouse. However, when the dose was decreased to 1 × 106/mouse, 4-1BB CAR-T cells were more potent in eradicating tumor cells and showed longer persistence than CD28 CAR-T cells. Retrospective analysis of an exploratory clinical study that used 4-1BB- or CD28-based CAR-T cells to treat r/r B-ALL was performed. Compared with CD28 CAR-T cells, 4-1BB CAR-T cells resulted in higher antitumor efficacy and less severe adverse events. This study demonstrated that the performance of 4-1BB CAR-T cells was superior to that of CD28 CAR-T cells in suppressing CD19+ B-ALL, at least under our manufacturing process.

10.1016/j.omto.2020.06.016

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The influence and curative effect analysis of tashione IIA injection liquid to the blood flow and change knowledge of unstable angina suffers

Sichuan Medical Journal (2008)

Min Xiong

Objective Compare the influence and curative effect analysis of tanshinone ⅡA to the blood flow and change knowledge of unstable angina suffers.Methods Review and analyze the 80 unstable angina suffers who are divided into curing team with 40 suffers and comparison team with 40 suffers.The curing team were given tanshinone ⅡA injection liquid 40mg,and the comparison team were given tanshen injection liquid 250ml,vein drop injection liquid,qd,and continuous 14d.Check the blood flow and change index after 14d injection.Results The curative effect of curing team is better than the comparison team;the change of blood flow and change index is obvious after curing for the curing team(P0.05).Conclusion tanshinone ⅡA injection liquid can improve curative effect,and improve the blood flow and change quality of unstable angina suffers effectively.

Unstable angina

Stable angina

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[An experimental study of prevention of peridural adhesion following laminectomy].

PubMed (1998)

Min Xiong Yueming Song L Liu

In order to find an ideal biological material to prevent peridural adhesion following laminectomy, 30 rabbits were used as animal model, in each of which 2 defects with a size of 1 cm x 0.5 cm were made following laminectomy of L3, L5 spine. One of the defects was covered extradurally with chitosan, gelatin foam or PLA membrane respectively, while the other defect was exposed as control. All of these animals were sacrificed on the 2nd, 4th, 6th, 8th and 10th week after operation, and the extradural fibrosis and adhesion of every animal were evaluated by gross observation and histological examinations. It was revealed that in the chitosan and PLA membrane groups, the extradural tissue was smooth without thickening and there was no fibrous proliferation or adhesion in the epidural cavity, and that in the chitosan group, the growth of fibroblast was restrained but the growth of the epithelial cells was promoted significantly, thus, wound healing was rapid. In the control group and gelatin foam group, obvious extradural fibrosis and adhesion were observed and the extradural space had almost disappeared. Therefore, it was concluded that the biodegradable PLA membrane and chitosan were both an ideal material in the prevention of postoperative epidural adhesion.

Gelatin

Epidural space

Tissue Adhesion

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Unmanipulated haplo-identical donor transplantation compared with identical sibling donor had better anti-leukemia effect for refractory/relapsed acute myeloid leukemia not in remission status

Annals of Hematology (2020)

Yue Lü Yanli Zhao Jianping Zhang Min Xiong Xingyu Cao

Cumulative incidence

Hematology

Refractory (planetary science)

Salvage therapy

10.1007/s00277-020-04283-0

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A comparative study of B_(16) melanoma strains in vitro

Chun‐Kui Shao Min Xiong

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Study on diagnosis and treatment of postoperative lumbar discitis

Zhonghua Yiyuan Ganranxue Zazhi (2013)

Sen Chen Hao Peng Min Xiong Liao Meimei

Discitis

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Body Mass Index and Risk of Female Reproductive System Tumors Subtypes: A Meta-analysis of Mendelian Randomization Study

Xiya Jiang Lan Zheng Min Xiong Senlin Wang Qinqin Jin

Participant or population Sample inclusion criteria: Have GWAS sequencing data and corresponding clinical information, including data release year, race, gender, research institution, sample size, PMID number, etc. Intervention There must be some difficult to avoid random errors in the selection and inclusion of IVs.Therefore, it is necessary to carry out "Leave-oneout" analysis of the data, eliminate one SNP in turn, and calculate the Mendelian randomisation analysis effect of the remaining SNP.Through the display of forest maps, we can intuitively judge the INPLASY

Mendelian Randomization

10.37766/inplasy2024.4.0025

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[The experimental study of the anti-damage effect of iminoethyl-lysine on noise-induced cochlea damage in guinea pig].

PubMed (2002)

Min Xiong Jiping Su Jian Wang Qinglian He Deng Hengshan

To investigate the anti-damage effect of iminoethyl-lysine on noise-induced cochlea damage in guinea pig.40 healthy red eye guinea pigs were randomly divided into 4 groups: Group A, normal control group; Group B, noise group; Group C, noise and drug group; Group D, iminoethyl-lysine group. Guinea pigs of both group B and group C were exposed to 115 dB white noise for 6 hours/day for 6 days. Group C and Group D were treated with iminoethyl-lysine(10 mg/kg) intraperitoneally, while Group B were treated with the same volume of physiological saline. ABR hearing threshold was measured in all animals before and after experiment. The expression of inducible nitric oxide synthase(NOS II) in the cochlea was examined by the method of immunohistochemistry. Also the cochlea of four groups were examined with scanning electronic microscope. ABR hearing threshold, expression of NOS II and structure of cochlea of four groups were compared with each other.There was no significant difference in ABR hearing threshold among four groups before the experiment(P > 0.05). There was no significant ABR hearing threshold shift in Group A and Group D after the experiment(P > 0.05), and there was significant ABR hearing threshold shift in Group B and Group C(P < 0.05). After the experiment, the ABR hearing threshold of group B(60.23 +/- 11.23) dB, was higher than that of Group C(38.46 +/- 7.24) dB, P < 0.05. The expression of NOS II was negative in the cochlea of Group A and Group D, but was stronger in Group B than that in Group C. The damage of outer hair cells of cochlea of Group B was more severe than that of Group C.The expression of NOS II in the guinea pig's cochlea damaged by noise is positive. Iminoethyl-lysine could inhibit the activity of NOS II and has the anti-damage effect on noise-induced cochlea damage. It is indicated that nitric oxide plays an important role in the pathogenesis of noise-induced hearing loss.

Group A

Auditory fatigue

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Danhong enhances recovery from residual dizziness after successful repositioning treatment in patients with benign paroxysmal positional vertigo

American Journal of Otolaryngology (2014)

Wenting Deng Chuanhong Yang Min Xiong FU Xiao-yan Huangwen Lai

10.1016/j.amjoto.2014.07.001

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Supplementary Figure 2 from VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages

Yan Zhang Quanjun Guo Zhujun Zhang Nan Bai Ze Liu

<p>PDF file - 2087KB, Administration of 1,25(OH)2D3 protects VDR expression and decreases metastasis induced by TNF-alpha and TGF-beta1 in MCF7 cells.</p>

10.1158/1541-7786.22514158.v1

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