Alexander Kluttig

Martin Luther University Halle-Wittenberg

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Karin Halina Greiser

German Cancer Research Center

Johannes Haerting

Martin Luther University Halle-Wittenberg

Henry Völzke

Universitätsmedizin Greifswald

Sabine Schipf

Heinrich Heine University Düsseldorf

Karl Werdan

University Hospital in Halle

Daniel Tiller

Martin Luther University Halle-Wittenberg

Annette Peters

Helmholtz Zentrum München

Christa Meisinger

University of Augsburg

Oliver Kuß

Heinrich Heine University Düsseldorf

Rafael Mikolajczyk

Martin Luther University Halle-Wittenberg

Cooperative Institutions

Charles R. Drew University of Medicine and Science

177

Martin Luther University Halle-Wittenberg

133

St. Paul's Hospital

112

Helmholtz Zentrum München

107

Heidelberg University

107

Heinrich Heine University Düsseldorf

101

Ludwig-Maximilians-Universität München

101

University of Cambridge

Charité - Universitätsmedizin Berlin

University of Groningen

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Genetic markers of tumour necrosis factor α in aggressive and chronic periodontitis

Journal Of Clinical Periodontology (2008)

Susanne Schulz Helmut K.G. Machulla Wolfgang Altermann Jana Klapproth Uta Zimmermann

Abstract Aim: Tumour necrosis factor α (TNF α ) plays an important role in the pathogenesis of periodontitis. TNF α production is influenced by gene polymorphisms. The aim of this study was to evaluate links between genetic variants and chronic/aggressive periodontitis in a multivariate model. Subjects: One hundred and twenty‐three periodontitis patients (chronic: n =54, aggressive: n =69) and 52 healthy controls without periodontitis were included in the study. Material and Methods: Single nucleotide polymorphisms (SNPs) c.−308G>A, c.−238G>A and haplotypes were analysed by a polymerase chain reaction with sequence‐specific primers (PCR‐SSP). The clinical investigation included smoking status, plaque and bleeding indexes, pocket depth and attachment loss. Results: Prevotella intermedia occurred more frequently in individuals positive for the −308GG/−238GG haplotype combination (Odds Ratio=2, 95% Confidence interval: 1.1–3.7, p =0.037, 1− β =61%). In binary logistic regression analyses, this TNF α haplotype could not be shown to be associated with periodontitis considering smoking, age, gender and approximal plaque index or subgingival bacterial colonization as confounding factors. Conclusions: Although the genetic background of TNF α could be shown to be associated with subgingival colonization with P. Intermedia , there is no evidence that it is an independent risk factor for periodontitis in multivariate models.

Aggressive periodontitis

Prevotella intermedia

10.1111/j.1600-051x.2008.01226.x

Cite

Citations (34)

Faktenblatt: Epidemiologie des multiplen Myeloms in Deutschland

Deleted Journal (2025)

Christine Eisfeld Frederik Peters Annemarie Schultz Andreas Stang Hiltraud Kajüter

10.1007/s00761-025-01680-w

Cite

Citations (0)

Krebserkrankungen des Ösophagus und ösophagogastrischen Übergangs: Inzidenz und Überleben in Deutschland, 2019–2022

Deleted Journal (2024)

Andreas Stang Ina Wellmann Bernd Holleczek Hiltraud Kajüter Alexander Katalinic

Primäre maligne Krebserkrankungen des Ösophagus und des ösophagogastrischen Übergangs sind prognostisch ungünstige Krebserkrankungen. Das Ziel dieser Arbeit ist es, für den aktuellsten Zeitraum 2019–2022 bundesweite Inzidenzen dieser Krebserkrankungen sowie die absoluten 5‑Jahres-Überlebenswahrscheinlichkeiten zu schätzen. Wir schlossen alle inzidenten Krebsfälle des Ösophagus (ICD-10: C15) und des ösophagogastrischen Übergangs (ICD-10: C16.0) aller Krebsregister in Deutschland der Jahre 2019–2022 ein. Wir ermittelten rohe und altersspezifische Inzidenzraten sowie altersgruppenspezifische durchschnittliche jährliche Neuerkrankungszahlen dieser Erkrankungen. Wir ermittelten die absoluten 5‑Jahres-Überlebenswahrscheinlichkeiten mittels Periodenansatz für die Periode 2018–2022 für ausgewählte Krebsregister. Insgesamt wurden 30.171 Patienten mit Ösophaguskrebs (davon 23,1 % Frauen) und 17.905 Patienten mit Krebs des ösophagogastrischen Übergangs (davon 22,5 % Frauen) registriert. Die Inzidenzrate pro 100.000 Personenjahre des Zeitraums 2019–2022 betrug für den Ösophaguskrebs 14,1 und 4,1 für Männer bzw. Frauen. Die korrespondierenden Inzidenzraten für Krebs des ösophagogastrischen Übergangs betrugen 8,4 und 2,4. Die absoluten 5‑Jahres-Überlebenswahrscheinlichkeiten unterschieden sich zwischen Männern und Frauen nur wenig. Sowohl im ersten Jahr als auch in den ersten 5 Jahren nach Diagnose von Ösophaguskrebs bzw. Krebs des ösophagogastrischen Übergangs zeigte sich sowohl bei Männern als auch bei Frauen, dass die Sterblichkeit bei Krebserkrankungen des ösophagogastrischen Übergangs geringer war als beim Ösophaguskrebs. Die ermittelten Inzidenzraten beruhen auf den Krebsregisterdaten aller Bundesländer in Deutschland, sodass auf spezifische Schätzverfahren für Deutschland insgesamt verzichtet und Selektionseffekte vermieden werden konnten. Wir präsentieren in dieser Übersichtsarbeit eine Zusammenfassung grundlegender Maßzahlen zur Häufigkeit von bösartigen Neubildungen des Ösophagus und des ösophagogastrischen Übergangs und der Prognose von Patienten mit diesen Krebserkrankungen.

10.1007/s00761-024-01650-8

Cite

Citations (0)

Association of subendocardial viability ratio and mortality in the elderly population: results from the CARdiovascular disease, Living and Ageing in Halle study

Journal of Hypertension (2023)

Artjom Schott Alexander Kluttig Rafael Mikolajczyk Anne Großkopf Karin Halina Greiser

Objectives: The subendocardial viability ratio (SEVR) reflects the balance of myocardial oxygen supply and demand. Low SEVR indicates a reduced subendocardial perfusion and has been shown to predict mortality in patients with kidney disease and diabetes. The aim of this study is to investigate the association of SEVR and mortality in the elderly population. Methods: We analysed data from the CARdiovascular disease, Living and Ageing in Halle (CARLA) study. SEVR was estimated noninvasively by radial artery tonometry and brachial blood pressure measurement. The study population was divided into a low (SEVR ≤130%) and normal (SEVR >130%) SEVR group. Cox-regression was used for survival analysis. Results: In total, 1414 participants (635 women, 779 men) aged from 50 to 87 years (mean age 67.3 years) were included in the analysis. The all-cause mortality was 22.7% during a median follow-up of 10.5 years. The unadjusted association of SEVR with all-cause mortality decreased from 3.52 (1.31–9.46) [hazard ratio (95% confidence interval) for low SEVR ≤ 130% versus normal SEVR > 130%] among those younger than 60 years to 0.86 (0.50–1.48) among those older than 80 years and from 1.81 (0.22–14.70) to 0.75 (0.30–1.91) for cardiovascular mortality. Sex-specific unadjusted analyses demonstrated an association of SEVR with all-cause and cardiovascular mortality in men [2.32 (1.61–3.34) and 2.24 (1.18–4.24)], but not in women [1.53 (0.87–2.72) and 1.14 (0.34–3.82)]. Conclusion: Our data suggests that SEVR is an age dependent predictor for all-cause mortality, predominantly in men younger than 60 years.

10.1097/hjh.0000000000003579

Cite

Citations (4)

Erratum zu: Krebserkrankungen des Ösophagus und ösophagogastrischen Übergangs: Inzidenz und Überleben in Deutschland, 2019–2022

Deleted Journal (2025)

Andreas Stang Ina Wellmann Bernd Holleczek Hiltraud Kajüter Alexander Katalinic

10.1007/s00761-025-01678-4

Cite

Citations (0)

Chronic disease outcome metadata from German observational studies – public availability and FAIR principles

Scientific Data (2023)

Carolina Schwedhelm Katharina Nimptsch Wolfgang Ahrens Hans Martin Hasselhorn Karl‐Heinz Jöckel

Abstract Metadata from epidemiological studies, including chronic disease outcome metadata (CDOM), are important to be findable to allow interpretability and reusability. We propose a comprehensive metadata schema and used it to assess public availability and findability of CDOM from German population-based observational studies participating in the consortium National Research Data Infrastructure for Personal Health Data (NFDI4Health). Additionally, principal investigators from the included studies completed a checklist evaluating consistency with FAIR principles (Findability, Accessibility, Interoperability, Reusability) within their studies. Overall, six of sixteen studies had complete publicly available CDOM. The most frequent CDOM source was scientific publications and the most frequently missing metadata were availability of codes of the International Classification of Diseases, Tenth Revision (ICD-10). Principal investigators’ main perceived barriers for consistency with FAIR principles were limited human and financial resources. Our results reveal that CDOM from German population-based studies have incomplete availability and limited findability. There is a need to make CDOM publicly available in searchable platforms or metadata catalogues to improve their FAIRness, which requires human and financial resources.

10.1038/s41597-023-02726-7

Cite

Citations (2)

Kohortenstudie zu Risikofaktoren für Herz-Kreislauf-Krankheiten in einer urbanen älteren ostdeutschen Allgemeinbevölkerung (CARLA-Studie)

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz (2012)

Johannes Haerting Alexander Kluttig Karin Halina Greiser Sebastian Nuding Karl Werdan

10.1007/s00103-012-1493-4

Cite

Citations (15)

Association of domain-specific physical activity and cardiorespiratory fitness with all-cause and cause-specific mortality in two population-based cohort studies

Scientific Reports (2018)

Martin Bahls Stefan Groß Sebastian E. Baumeister Henry Völzke Sven Gläser

Abstract Physical activity (PA) reduces the risk for mortality. Whether the beneficial effects of PA are domain specific is unclear. We associated leisure time (LTPA), sports (SPA) and work (WPA) related PA and cardiorespiratory fitness (CRF) with all-cause mortality in two German population-based cohorts. We used data of the Study of Health in Pomerania (SHIP, n = 2,935, median age 53; 48% male) and the Cardiovascular Disease, Living and Ageing in Halle study (CARLA, n = 1,776, median age 64 and 54% male). Mortality was determined after a median follow-up of 8.2 years in SHIP (n = 332) and 11.5 years in CARLA (n = 409). LTPA (SHIP: hazard ratio [HR] per standard deviation [SD] 0.82 95%-CI 0.73 to 0.91 and CARLA: HR per SD 0.70: 95%-CI 0.59 to 0.82) and SPA (SHIP: HR per SD 0.80 95%-CI 0.71 to 0.91 and CARLA: HR per SD 0.70 95%-CI 0.60 to 0.82) but not WPA were inversely associated with all-cause mortality. In a subsample CRF was inversely related to mortality and positively to LTPA and sports SPA. No association was found for WPA. Our results may suggest that the inverse association between PA and mortality are partly influenced by higher CRF.

Association (psychology)

10.1038/s41598-018-34468-7

Cite

Citations (34)

Neue Ergebnisse zur Epidemiologie des Typ 2 Diabetes – Süd-Nord-Gradient in der Prävalenz des bekannten Typ 2 Diabetes in Deutschland (DIAB-CORE Verbund)

Diabetologie und Stoffwechsel (2011)

Sabine Schipf Andreas Werner T. Tamayo Rolf Holle Michaela Schunk

Hintergrund: In Deutschland gibt es bislang wenig populationsbezogene Daten zur regionalen Verteilung des Typ 2 Diabetes mellitus (T2DM). Ein Zusammenschluss von populationsbasierten Studien aus unterschiedlichen Regionen Deutschlands im DIAB-CORE Verbund des Kompetenznetz Diabetes liefert erstmals die Datengrundlage für regionale Analysen. Diese ermöglichen Schätzungen zur Prävalenz des T2DM und dessen Variabilität in unterschiedlichen Regionen Deutschlands.

10.1055/s-0031-1277263

Cite

Citations (1)

Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization – design and objectives of the Diagnosis Optimisation Study (DIOS)

BMC Cancer (2007)

Alexander Kluttig Pietro Trocchi A. Heinig Hans-Juergen Holzhausen Christiane Taege

The planned nationwide implementation of mammography screening 2007 in Germany will increase the occurrence of mammographically detected breast abnormalities. These abnormalities are normally evaluated by minimal invasive core biopsy. To minimize false positive and false negative histological findings, quality assurance of the pathological evaluation of the biopsies is essential. Various guidelines for quality assurance in breast cancer diagnosis recommend applying the B-classification for histopathological categorization. However, to date there are only few studies that reported results about reliability and validity of B-classification. Therefore, objectives of our study are to determine the inter- and intraobserver variability (reliability study) and construct and predictive validity (validity study) of core biopsy evaluation of breast abnormalities. This paper describes the design and objectives of the DIOS Study. All consecutive asymptomatic and symptomatic women with breast imaging abnormalities who are referred to the University Hospital of Halle for core breast biopsy over a period of 24 months are eligible. According to the sample size calculation we need 800 women for the study. All patients in the study population underwent clinical and radiological examination. Core biopsy is performed by stereotactic-, ultrasound- or magnetic resonance (MR) guided automated gun method or vacuum assisted method. The histopathologic agreement (intra- and interobserver) of pathologists and the histopathologic validity will be evaluated. Two reference standards are implemented, a reference pathologist and in case of suspicious or malignant findings the histopathologic result of excision biopsy. Furthermore, a self administrated questionnaire which contains questions about potential risk factors of breast cancer, is sent to the participants approximately two weeks after core biopsy. This enables us to run a case-control-analysis (woman with breast cancer histological verified after excision are defined as cases, woman without malignant breast lesions are defined as controls) to investigate the predictive values of various risk factors on breast cancer risk. The analysis of reliability and validity of the histopathological evaluation of core biopsy specimens of breast abnormalities is intended to provide important information needed for a high quality in breast cancer diagnostic and for planning of treatment strategies.

Breast imaging

Breast biopsy

10.1186/1471-2407-7-100

Cite

Citations (12)