随意運動において,ペーシング音の前補足運動野(pre-SMA)および補足運動野(SMA proper)に対する影響を,機能的MRIを使用し,健常成人10人を対象に検討した.運動課題は母指の各指への順序だった対立運動で,自己ペースで行う場合と,メトロノームによる聴覚誘導で行う場合を比較した.大脳皮質の賦活は,それぞれの領域に10の関心領域をとり,MRI信号強度(t値)として検出,分析した.右手では,自己ペース運動の場合,10例中6例で右のSMA properに,3例で左のSMA properに賦活が見られた.そして,ペーシング音により,各々,6例中5例,3例中2例で同領域の活動は消失もしくは減少した.一方,左手では,自己ペース運動の場合,10例中5例で右のSMA properに,1例で左のSMA properに賦活が見られた.そして,ペーシング音により,各々,5例中4例,1例中1例で同領域の活動は消失もしくは減少した.しかし右手,左手いずれも,pre-SMAの活動は1例のみにみられ,いずれもペーシング音で減少した.ペーシング音により,特にSMA properの活動が低下する傾向がみられ,こうした現象から,パーキンソン病に対し従来から行われる外的手がかりによる運動の改善には,補足運動野以外の賦活が関与していることが示唆された.

Supplementary motor area

10.2490/jjrm1963.41.472

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ラットにおけるNMS60を使用したMR血管造影 : Gd-DTPAとの比較

宏起吉川守男嶋田優介井上淳史妹尾重実世利

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The Characteristics of Inverter Type 50kW X-ray Generator : Resonance type, Inverter Frequency 20kHz

Japanese Journal of Radiological Technology (1998)

Shinji Abe Toru Negishi Izumi Ogura Yutai Katoh Atsushi Seno

10.6009/jjrt.kj00001351848

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Phantom and animal studies of a new hepatobiliary agent for MR imaging: Comparison of Gd‐DTPA‐DeA with Gd‐EOB‐DTPA

Journal of Magnetic Resonance Imaging (2003)

Kohki Yoshikawa Yusuke Inoue Masaaki Akahane Morio Shimada Sayaka Itoh

Abstract Purpose: To investigate the characteristics of Gd‐DTPA‐DeA as a hepatobiliary contrast agent for MR imaging in comparison with those of Gd‐EOB‐DTPA. Materials and Methods: We undertook phantom experiments to assess T1 relaxivity for Gd‐DTPA‐DeA, Gd‐EOB‐DTPA, and Gd‐DTPA in human plasma. For Gd‐DTPA‐DeA and Gd‐EOB‐DTPA, we evaluated the contrast effect in rats using an SPGR sequence. The contrast ratios of liver and abdominal aorta were measured up to 21 minutes after intravenous administration of the agents. Visualization of the bile duct and renal pelvis was also assessed. Results: In human plasma, T1 relaxivity was similar for Gd‐DTPA‐DeA and Gd‐EOB‐DTPA, and higher than those for Gd‐DTPA. Whereas the contrast ratio of liver peaked about five minutes after the injection of Gd‐EOB‐DTPA and was followed by a subsequent decline, a continuous rise was shown for Gd‐DTPA‐DeA, resulting in a larger maximal contrast effect. Contrast ratios of the abdominal aorta were larger for Gd‐DTPA‐DeA. Biliary excretion was observed for both agents but occurred earlier with Gd‐EOB‐DTPA. While renal excretion was shown for all rats three minutes after the injection of Gd‐EOB‐DTPA, it was not observed for Gd‐DTPA‐DeA. Conclusion: Gd‐DTPA‐DeA may be used as a hepatobiliary contrast agent and shows different pharmacokinetics from Gd‐EOB‐DTPA. J. Magn. Reson. Imaging 2003;18:204–209. © 2003 Wiley‐Liss, Inc.

10.1002/jmri.10349

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Neural activation during imitation of movements presented from four different perspectives: A functional magnetic resonance imaging study

Neuroscience Letters (2011)

Rui Watanabe Shu Watanabe Hironobu Kuruma Yoshiyuki Murakami Atsushi Seno

Neural substrate

10.1016/j.neulet.2011.08.016

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