Carolina Foot Gomes de Moura

Universidade Federal de São Paulo

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Daniel Araki Ribeiro

Universidade Federal de São Paulo

Flávia Andressa Pidone Ribeiro

Universidade Federal de São Paulo

Odair Aguiar

Universidade Federal de São Paulo

Victor Hugo Pereira da Silva

Universidade Federal de São Paulo

Celina Tizuko Fujiyama Oshima

Universidade Federal de São Paulo

Wagner Vilegas

Universidade Estadual Paulista (Unesp)

Marcelo José Dias Silva

Universidade Federal de Alfenas

Gustavo Protasio Pacheco de Jesus

Centro Universitário Lusíada

Bianca Andrade Handan

Universidade Federal de São Paulo

Ana Cláudia Muniz Rennó

Universidade Federal de São Paulo

Cooperative Institutions

Universidade Federal de São Paulo

Universidade de São Paulo

Universidade Estadual de Campinas (UNICAMP)

Fundação de Apoio à Universidade Federal de São Paulo

Universidade Estadual Paulista (Unesp)

Instituto de Saúde

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Metropolitana de Santos

Universidade Federal de São Carlos

Hospital de Clínicas da Unicamp

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Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats

Environmental Science and Pollution Research (2014)

Victor Hugo Pereira da Silva Carolina Foot Gomes de Moura Flávia Andressa Pidone Ribeiro Augusto César Camilo Dias Seabra Pereira

Comet Assay

10.1007/s11356-014-3261-5

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Citations (10)

Effects Of Paradoxal Sleep Deprivation On Liver Functionality Of Sedentary Rats

Medicine & Science in Sports & Exercise (2017)

Marcus L. Santos Marcos Mônico‐Neto Kil Sun Lee Carolina Foot Gomes de Moura Daniel Araki Ribeiro

PURPOSE: Evaluate the influence of PSD and sleep recovery (SR) on the integrity and functionality of liver in sedentary rats METHODS: Thirty male Wistar rats, 3 month old, were distributed into 3 groups: Control (CTRL), submitted to PSD for 96h (PSD96), and PSD for 96h plus sleep recovery period for 96h (SR96). After the protocol, the rats were euthanized and blood sample were collected to analyze corticosterone, insulin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). A central fragment of liver was process by immunohistochemistry and the 8OHDG, TNF-alfa, COX-2 inflammation and oxidative stress biomarkers was performed. The data were analyzed by one-way ANOVA with Tukey post hoc, p<0.05. The present study was approved by ethics and research committee of Universidade Federal de São Paulo (8357240615). RESULTS: The corticosterone and AST concentrations increased in PSD96 and SR96 respectively compared to CTRL (148.87±71.06 vs 44.58±24.34; 95.03±18.47 vs 61.44±15.5 respectively; P<0.05) and insulin in PSD96 group decreased compared to CTRL (0.96±0.94 vs 5.72±2.88 respectively; P<0.05). The qualitative immunohistochemistry analysis showed an increase in 8OHDG and COX2 in SR96 group compared to CTRL (2.4±0.89 vs 0.66±0.51; 1.16±0.40 vs 0.33±0.51 respectively; P<0.05). No changes were seen for other variables. CONCLUSIONS: Hormonal and metabolic changes associated with PSD can modify parameters of inflammation and oxidative stress in the liver of sedentary rats. Physical exercise could be an important strategy to minimize the effects observed with PSD.

Corticosterone

Alanine aminotransferase

10.1249/01.mss.0000519806.16438.4f

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Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide

Pathology (2014)

Daniel Araki Ribeiro Flávia Andressa Pidone Ribeiro Carolina Foot Gomes de Moura Andréa Pittelli Boiago Gollücke

4-Nitroquinoline 1-oxide

10.1097/01.pat.0000454418.46650.6b

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Citations (1)

Mimosa (Mimosa caesalpiniifolia)prevents oxidative DNA damage induced by cadmium exposure in Wistar rats

Toxicology Mechanisms and Methods (2014)

Marcelo José Dias Silva Wagner Vilegas Marcelo Aparecido da Silva Carolina Foot Gomes de Moura Flávia Andressa Pidone Ribeiro

The Mimosa (Mimosa caesalpiniifolia) is a plant native from South America; it is used in the traditional medicine systems for treating bacterial, fungal, parasitic and inflammatory conditions. The aim of this study was to evaluate the antigenotoxic and antioxidant activities induced by mimosa (M. caesalpiniifolia) in multiple rodent organs subjected to intoxication with cadmium chloride. A total of 40 Wistar rats (8 weeks old, 250 g) were distributed into eight groups (n = 5), as follows: Control group (non-treated group, CTRL); Cadmium exposed group (Cd); cadmium exposure and treated with extract at 62.5 mg/kg/day; cadmium exposure and treated with extract at 125 mg/kg/day; cadmium exposure and treated with extract at 250 mg/kg/day; cadmium exposure and treated with ethyl acetate fraction at 62.5 mg/kg/day. For evaluating the toxicogenetic potential of mimosa, two groups were included in the study being treated with extract at 250 mg/kg/day and acetate fraction of mimosa at 62 mg/kg/day, only. Extract of mimosa at concentrations of 62.5 and 125 mg decreased DNA damage in animals intoxicated with cadmium when compared to cadmium group. In a similar manner, treatment with ethyl acetate fraction of mimosa at 62.5 mg concentration in animals previously exposed to cadmium reduced genetic damage in peripheral blood cells. In a similar manner, the treatment with ethyl acetate fraction reduced DNA damage in liver cells. Oxidative DNA damage was reduced to animals exposed to cadmium and treated with 125 mg of extract as well as those intoxicated to cadmium and treated with 62.5 of acetate fraction of mimosa. Taken together, our results indicate that mimosa prevents genotoxicity induced by cadmium exposure in liver and peripheral blood cells of rats as a result of antioxidant activity.

Cadmium chloride

Cadmium acetate

10.3109/15376516.2014.955230

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Citations (13)

Cytotoxicity, Inflammatory Activity, and Angiogenesis Are Induced by Different Silicone Implants

In Vivo (2022)

RODRIGO BREDARIOL ACHILLES Daniel Vitor de Souza Hananiah Tardivo Quintana Andréa Cristina de Moraes Malinverni Carolina Foot Gomes de Moura

The aim of this study was to investigate cytotoxicity, inflammatory response, and angiogenesis induced by silicone gel breast implants with different textured surfaces in vitro and in vivo.In the in vitro study, murine fibroblast cells (L929) were cultured for 1, 3, and 5 days with silicone membranes of three different textures: nanotextured, microtextured, and silicone foam. In the in vivo study, a total of 30 male rats (Rattus, norvegicus, albinos, Wistar) were distributed into three groups (10 animals per group), with 2 implants in each rat: nanotextured silicone gel breast implants group, microtextured silicone gel breast implants group, and silicone gel breast foam implants group.The Alamar Blue assay detected higher viability of cells cultured in the presence of nanotextured silicone surface for 1 and 3 days. The MTT assay showed higher cytotoxicity of silicone foam after 1 and 3 days of exposure. Nanotextured silicone breast implants induced a more prolonged inflammatory response, denoting a delay in the healing process and subsequent organization of the fibrous capsule as depicted by the collagen fiber types found. VEGF expression did not differ between experimental groups.Gel foam breast implants are more biocompatible when compared to micro- or nano-textured silicone breast implants.

Capsule

Breast implant

10.21873/invivo.12824

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Citations (3)

Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Medical Oncology (2018)

Gláucia Resende Soares Carolina Foot Gomes de Moura Marcelo José Dias Silva Wagner Vilegas Aline Boveto Santamarina

Daucus carota

4-Nitroquinoline 1-oxide

Carrot juice

10.1007/s12032-018-1114-7

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Citations (22)

Are food compounds able to modulate noxious activities induced by cadmium exposure?

Critical Reviews in Food Science and Nutrition (2015)

Carolina Foot Gomes de Moura Daniel Araki Ribeiro

ABSTRACTCadmium is one of the most toxic environmental and industrial pollutants and is able to induce severe injury because it is poorly excreted, accumulating in various organs. This common pollutant is responsible for serious damage in lung, brain, testis, kidney, liver, circulatory system, and bone. Food compounds, such as flavonoids, represent the most abundant polyphenols in human diet and comprise thousands of substances, which are freely available as high-dose dietary supplements. The mechanism of action of these ones consists in free radical scavenging and metal sequestration. The interaction of metal ions with flavonoids leads to chelation and the use of these natural compounds is better than the synthetic ones due to their lower toxic effects. The aim of this review is to describe the role of some food compounds, focusing on flavonoids for modulating noxious biological activities induced by cadmium exposure.KEYWORDS: Flavonoidscadmiumtoxicitynutrition AcknowledgmentsThis study was supported by CNPq and CAPES.Conflict of InterestNone declared.

Detoxification

10.1080/10408398.2014.911719

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Citations (18)

Antitumor Essential Oils: Synergy and Chemotherapeutic Interactions

Springer eBooks (2015)

Rogério Corrêa Peres Carolina Foot Gomes de Moura Flávia Andressa Pidone Ribeiro Daniel Araki Ribeiro

Chemotherapeutic drugs

Cancer Treatment

10.1007/978-3-319-19144-7_11

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Citations (0)

Limb compression induces multi-system genetic damage in rats

Pathophysiology (2013)

Nicola Jorge Carneiro Neto Maurício Wanderley Moral Sgarbi Carolina Foot Gomes de Moura Gustavo Protasio Pacheco de Jesus Daniel Araki Ribeiro

Muscle crush injury is a common trauma in the modern society after as a result of mass disasters after penetration into muscle by high-velocity projectiles, blunt external trauma, or by gravity during prolonged immobilization in comatose patients after head trauma, alcoholic or drug overdose. However, the underlying mechanisms linking these alterations are still not fully understood, especially in acute phase. The aim of this study was to analyze genomic instability in multiple organs of rats after acute muscle injury by means of single cell gel (comet) assay. Rats were randomly distributed into three groups (n=6 each group): control group and experimental groups: sacrificed 6h as 12h after muscle compression. These results indicate genetic damage in peripheral blood cells as depicted by tail moment results. DNA breakage was also detected in liver, lung and kidney cells after acute muscle injury for two times evaluated. Heart cells showed genetic damage after 12h following muscle compression. Taken together, our results suggest that acute muscle injury induces genomic damage in multiple organs of Wistar rats. This novel finding offers new insights into the underlying mechanisms of the relationship between acute crush muscle injury and clinical manifestations that can occur during limb compression.

Crush syndrome

10.1016/j.pathophys.2013.10.002

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The chemopreventive activity of apple against carcinogenesis

European Journal of Cancer Prevention (2014)

Flávia Andressa Pidone Ribeiro Carolina Foot Gomes de Moura Odair Aguiar Flávia de Oliveira Regina Célia Spadari

Apples and their derivatives are rich in phytochemicals, including flavonoids (catechins, flavonols, quercetin) and phenolic acids (quercetin glycosides, catechin, epicatechin, procyanidins), vitamins, and fibers, that confer an important antioxidant property. Chemoprevention is defined by the use of natural or synthetic agents to interfere with the progression, reverse, or inhibit carcinogenesis, thereby reducing the risk of developing clinically invasive disease. The aim of this article is to present data generated from the use of apples as a chemopreventive agent in carcinogenesis using in-vivo and in-vitro test systems. Apple and its bioactive compounds can exert chemopreventive properties as a result of antioxidant activity and cell cycle control. However, future focus of research on apple such as identifying the specific phytochemical responsible for the anticarcinogenic effect, timing of consumption, and adequate amount of apples to achieve the best preventive effect using human large randomized-controlled trials is needed. Furthermore, animal studies are also relevant for better understanding the role of this fruit in human health as well as modulation of degenerative diseases such as cancer. Therefore, this area warrants further investigation as a new way of thinking, which would apply not only to apples but also to other fruit used as promising therapeutic agents against human diseases.

Phytochemical

Flavonols

Human studies

10.1097/cej.0000000000000005

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Citations (17)