Mirella Alves Cunha

Universidade Federal do Rio Grande do Norte

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JÂ

José Ângelo Lauletta Lindoso

Instituto de Infectologia Emílio Ribas

MARIANNA MARTINS LAGO

Instituto de Infectologia Emílio Ribas

Eudes Alves Simões Neto

Universidade Federal do Maranhão

Aline Santos Ibanês

Instituto de Infectologia Emílio Ribas

LILIAN MITIKO OUKI

Instituto de Infectologia Emílio Ribas

Kléber Giovanni Luz

Universidade Federal do Rio Grande do Norte

MARIA ALMERICE LOPES SILVA

Faculdade de Agudos

NORIVAL KESPER

Universidade de São Paulo

JOSE ANGELO LAULETTA LINDOSO

Universidade de São Paulo

MAHYUMI FUGIMORI

Universidade de São Paulo

Cooperative Institutions

Universidade Federal do Rio Grande do Norte

Universidade de São Paulo

Instituto de Infectologia Emílio Ribas

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Federal de São Paulo

Hospital Universitário Onofre Lopes

Universidade do Porto

Instituto de Medicina Tropical

Universidade Federal de Pernambuco

Ministério da Saúde

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[Therapeutic use of dimercaptosuccinate of antimony and sodium (Astiban) in the treatment of Manson's schistosomiasis].

PubMed (1965)

D Teixeira O F de Gouveia Ayako Miyahira E Galper Mirella Alves Cunha

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Citations (0)

Rhinocerebral zygomycosis in a diabetic patient

Revista da Sociedade Brasileira de Medicina Tropical (2011)

Mirella Alves Cunha Andréia Ferreira Nery Francisco Pignataro Lima José Diniz Júnior José Maciel Neto

Rhinocerebral zygomycosis is the most frequent form of fungal infection caused by members of the Zygomycetes class. A fatal case of rhinocerebral zygomycosis caused by Rhizopus (oryzae) arrhizus with histopathological and mycological diagnosis is reported in a diabetic patient.

Zygomycosis

Rhizopus arrhizus

Rhizopus oryzae

Rhizopus

10.1590/s0037-86822011000200027

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Citations (12)

Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study

Research Square (Research Square) (2019)

Mirella Alves Cunha BEATRIZ CELESTE NORIVAL KESPER MAHYUMI FUGIMORI MARIANNA MARTINS LAGO

Abstract Background: There is little information about the frequency of Leishmaniainfection in asymptomatic HIV infected individuals and about the performance of laboratory diagnostic methods in coinfected patients in Latin America. The main objective of this study is to evaluate the frequency of Leishmaniaspp. infection in HIV infected patients living in an urban area from Brazil. Methods: To detect Leishmaniainfection, were performed diagnostic tests to detection of antibodies anti-Leishmania(ELISA using Leptomonas seymouriantigens; ELISA using rk39 antigens; ELISA using rK28 antigens; indirect fluorescent-antibody test (IFAT); direct agglutination test (DAT) and detection of LeishmaniaDNA by polymerase chain reaction (PCR) with the target genes kDNA and ITS-1. Results: Frequency, considering at least one positive test, was 15%. For ELISA using Leptomonasantigens and IFAT, there was an association between CD4+ T-lymphocyte counts and test positivity, with a higher positivity of these tests in more immunosuppressed patients (T CD4+ cells count < 200/mm3). Conclusions: According to our data, there was a high prevalence of Leishmaniaspp. in this population living with HIV. Although there is the possibility of cross-reaction, some tests considered highly specific for the diagnosis of Leishmania infection were positive. There was also an association between the positivity of some tests studied and lower values of T CD4+ lymphocytes.

Direct agglutination test

Cross-sectional study

Direct fluorescent antibody

10.21203/rs.2.18499/v1

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Citations (0)

Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study

Research Square (Research Square) (2020)

Mirella Alves Cunha BEATRIZ CELESTE NORIVAL KESPER MAHYUMI FUGIMORI MARIANNA MARTINS LAGO

Abstract Background: There is little information about the frequency of Leishmania infection in asymptomatic people living with HIV (PLWH) and about the performance of laboratory diagnostic methods in coinfected patients in Latin America. The main objective of this study is to evaluate the frequency of Leishmania spp. infection in HIV-infected patients living in an urban area in Brazil.Methods: To detect Leishmania infection, diagnostic tests were performed to detect anti- Leishmania antibodies (ELISA using Leptomonas seymouri antigens; ELISA using rK39 antigens; ELISA using rK28 antigens; indirect fluorescent-antibody test (IFAT); direct agglutination test (DAT)) and Leishmania DNA (polymerase chain reaction (PCR) with the target genes kDNA and ITS-1).Results: The frequency of at least one positive test was 15%. For ELISA using Leptomonas antigens and IFAT, there was an association between CD4+ T lymphocyte counts and test positivity, with a higher positivity of these tests in more immunosuppressed patients (CD4+ T cell count < 200/mm 3 ).Conclusions: According to our data, there was a high prevalence of Leishmania spp. infections in this population living with HIV. Although there is the possibility of cross-reaction, some tests that are considered highly specific for the diagnosis of Leishmania infection were positive. There was also an association between the positivity of some tests studied and lower values of CD4+ T lymphocytes.

Direct agglutination test

10.21203/rs.2.18499/v3

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Citations (0)

Case Report/Relado de Caso

Mirella Alves Cunha Andréia Ferreira Ner Francisco Pignataro Lima José Miguel Diniz José Maciel Neto

Zygomycosis

Rhizopus arrhizus

Rhizopus oryzae

Source

Cite

Citations (0)

ENTEROCOLITE NECROSANTE COMO MANIFESTAÇÃO DE INFECÇÃO POR CITOMEGALOVIRUS: RELATO DE CASO

The Brazilian Journal of Infectious Diseases (2021)

Ana F.M. Alcoforado Edlana R.V.G. Lins Mireile A. Genuíno Patrícia L. Albernaz Mirella Alves Cunha

10.1016/j.bjid.2020.101509

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Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study

BMC Infectious Diseases (2020)

Mirella Alves Cunha Beatriz Julieta Celeste Norival Kesper M. Fugimori MARIANNA MARTINS LAGO

Abstract Background There is little information about the frequency of Leishmania infection in asymptomatic people living with HIV (PLWH) and about the performance of laboratory diagnostic methods in coinfected patients in Latin America. The main objective of this study is to evaluate the frequency of Leishmania spp. infection in HIV-infected patients living in an urban area in Brazil. Methods To detect Leishmania infection, diagnostic tests were performed to detect anti- Leishmania antibodies (ELISA using Leptomonas seymouri antigens; ELISA using rK39 antigens; ELISA using rK28 antigens; indirect fluorescent-antibody test (IFAT); direct agglutination test (DAT)) and Leishmania DNA (polymerase chain reaction (PCR) with the target genes kDNA and ITS-1). Results The frequency of at least one positive test was 15%. For ELISA using Leptomonas antigens and IFAT, there was an association between CD4+ T lymphocyte counts and test positivity, with a higher positivity of these tests in more immunosuppressed patients (CD4+ T cell count < 200/mm 3 ). Conclusions According to our data, there was a high prevalence of Leishmania spp. infections in this population living with HIV. Although there is the possibility of cross-reaction, some tests that are considered highly specific for the diagnosis of Leishmania infection were positive. There was also an association between the positivity of some tests studied and lower values of CD4+ T lymphocytes.

Direct agglutination test

Medical microbiology

Parasitology

10.1186/s12879-020-05622-2

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Citations (7)

Case Report: Severe Visceral Leishmaniasis in a Patient with HIV Coinfection Undergoing Treatment for Erythema Nodosum Leprosum

American Journal of Tropical Medicine and Hygiene (2020)

S. Aquino Lucyo Flávio Bezerra Diniz Igor Thiago Queiroz Mirella Alves Cunha Alda Maria Justo

We report a case of visceral leishmaniasis (VL)/HIV coinfection in a patient undergoing regular antiretroviral therapy and treatment with thalidomide for erythema nodosum leprosum. He presented at a health service with high fever, chills, asthenia, pale skin, lower limb edema, hepatomegaly, and splenomegaly. Visceral leishmaniasis was confirmed by direct examination, and serological and molecular tests. Serum levels of Th1/Th2 cytokines were measured. The patient began treatment with liposomal amphotericin B, with good clinical response; however, VL recurred 6 months later. Treatment was reinitiated, maintaining secondary prophylaxis with liposomal amphotericin B. The patient showed clinical improvement with important recovery of CD4+ T-lymphocyte count.

Chills

10.4269/ajtmh.20-0567

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Citations (0)

[Therapeutic use of antimony and sodium dimercaptosuccinate in the treatment of schistosomiasis mansoni].

PubMed (1965)

D Teixeira O F de Gouveia Ayako Miyahira E Galper Mirella Alves Cunha

Source

Cite

Citations (0)

Efficacy and Safety of Liposomal Amphotericin B for the Treatment of Mucosal Leishmaniasis from the New World: A Retrospective Study

American Journal of Tropical Medicine and Hygiene (2015)

Mirella Alves Cunha Aline Carralas Queiroz de Leão Rita de Cássia Soler José Ângelo Lauletta Lindoso

The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.

Amphotericin B deoxycholate

10.4269/ajtmh.15-0033

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Citations (48)