Arzu Yazal Erdem

Sağlık Bilimleri Üniversitesi

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Co-Authors

DÖ

Derya Özyörük

Sağlık Bilimleri Üniversitesi

NÖ

Namık Özbek

Memorial Ankara Hospital

Neşe Yaralı

Ankara Yıldırım Beyazıt University

Neriman Sarı

Sağlık Bilimleri Üniversitesi

Suna Emir

Atilim University

Bahattin Tunç

Özel Ankara Umut Hastanesi

Dilek Kaçar

Sağlık Bilimleri Üniversitesi

Ayça Koca Yozgat

Sağlık Bilimleri Üniversitesi

SÇ

Selma Çakmakçı

Ankara Bilkent City Hospital

Zeliha Güzelküçük

Pediatrics and Genetics

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

104

Memorial Ankara Hospital

Ministry of Health

University of Health Science

Ankara Onkoloji Eğitim ve Araştırma Hastanesi

City Hospital

Ankara Bilkent City Hospital

Bilkent University

University of Health Sciences

Ankara Yıldırım Beyazıt University

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IMPACT OF COVID-19 PANDEMIC ON DELAY OF CHILDHOOD CANCER DIAGNOSIS AND THE OUTCOMES IN A PEDIATRIC HEMATOLOGY/ONCOLOGY DEPARTMENT

Hematology Transfusion and Cell Therapy (2022)

Selma CAKMAKCI Neriman Sarı Arzu Yazal Erdem Sonay İncesoy Özdemir Derya Özyörük

Restriction of access to healthcare during COVID-19 pandemic is undoubtedly a major problem for patients with cancer. Although childhood cancers are highly curable, it is obvious that diagnostic and treatment disruptions will lead to poor Results. In this study we investigated the effects of pandemic on diagnosis and treatment delays of children with cancer along with their consequences. We searched all pediatric patients treated for cancer between March 2020 and January 2022 for COVID-19 infection. Data were collected collected from medical files of patients diagnosed with COVID-19, confirmed by polymerase chain reaction (PCR), who received active antineoplastic treatment. Fifty-eight patients developed COVID-19 infection at different stages of their anticancer treatment. Twenty-five had an asymptomatic COVID-19 infection, twenty-six had mild symptoms, three had moderate symptoms and four had severe disease. All of them recovered from COVID-19 infection. Chemotherapy courses were continued during active infection in four patients and interrupted in other patients. While strict measures are required to control the pandemic, patients with severe critical illness such as cancer should be carefully evaluated and treatment delays that may have vital consequences should be avoided. In pediatric patients with cancer whom infected by COVID-19, continuation of anticancer treatment may be considered by evaluating the clinical status of the patient.

Pandemic

Hematology

Pediatric cancer

10.1016/j.htct.2022.09.1229

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Comparison of prophylactic use of intravenous immunoglobulin versus Pentaglobin^® in pediatric patients after hematopoietic stem cell transplantation

Pediatric Transplantation (2015)

Fatih Azık Cengiz Bayram Mustafa Erkoçoğlu Hasan Tezer Arzu Yazal Erdem

Abstract There are few studies evaluating the use of I g M ‐enriched IVIG ( P entaglobin ® ) in HSCT recipients. This study aimed to compare the efficacy of prophylactic use of IVIG versus prophylactic use of P entaglobin ® within the first 100 days after allogeneic HSCT . We performed a prospective, randomized study of the use of prophylactic IVIG versus prophylactic use of P entaglobin ® in patients after allogeneic HSCT . The first dose of IVIG or P entaglobin ® was given before conditioning regimen and after transplant was given on day +1, +8, +15, and +22. And then, it was given if I g G level was below 400 mg/dL. Twenty‐seven patients in IVIG group and 32 patients in P entaglobin ® group were included in the study. There were no significant differences in the duration of neutropenia, hospitalization, fever, and in the number of pyrexial episode, septicemia, bacteremia, local infection, CMV infection, acute GVHD , VOD , and adverse events between the IVIG group and P entaglobin ® group. Randomized placebo‐controlled trials are needed to conclude that utilization of IVIG or P entaglobin ® has no beneficial effect in HSCT .

Bacteremia

10.1111/petr.12636

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Citations (5)

A Rare Diagnosis in Children

Journal of Pediatric Hematology/Oncology (2019)

Zeliha Güzelküçük Derya Özyörük Ayça Koca Yozgat Can Barış Aker Hasan Fatih Çakmaklı

10.1097/00043426-900000000-97666

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Lösemili Çocuklarda SARS COV-2 Enfeksiyonu

Turkish Journal of Pediatric Disease (2020)

Arzu Yazal Erdem Namık Özbek

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directed great attention and anxiety all over the world. Epidemiologic models predict that the current COVID-19 pandemic will last several months or even several years, until the development of a vaccine and/or herd immunity. Although the course of the infection is often not severe in children, it can be life threatening especially in immunocompromised children with leukemia. Hematopoietic and lymphoid cancers are accounting for approximately 40% of all childhood cancers. The five-year survival rate for childhood cancer has approached to 70% and more than 80% for leukemia in our country. During COVID pandemic, children with leukemia may also have COVID-19 infection, especially when their bone marrow is depressed due to chemotherapy. It is observed that factors such as the underlying type of cancer, status of remission, or having stem cell transplantation may affect the prognosis. As well as standard and proven treatments for febrile neutropenia, all tests and treatments should be applied very quickly and properly for COVID 19 as is all suspected patients. These efforts may contribute to increase the survival of our children with cancer. Given the absence of data to address concerns related to SARS-CoV-2 infection while on chemotherapy, questions are increasing about the approach for management of systemic immunosuppressive therapies, i.e. ceasing or reducing the immunosuppressive medications in children with leukemia. The current rapid worldwide spread of COVID-19 necessitates identifying optimal preventive strategies and effective medical management. In this report, we tried to review appropriate literature-based approaches for prevention, diagnosis and management of treatment protocols for children with cancer during the pandemic period.

Pandemic

10.12956/tchd.743711

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Citations (1)

BURKITT LYMPHOMA PRESENTING WITH EYE AND KIDNEY INVOLVEMENT: CASE REPORT

Hematology Transfusion and Cell Therapy (2021)

Aslı Yılmaz Derya Özyörük Neriman Sarı Fatma Burçin Kurtipek Arzu Yazal Erdem

Burkitt lymphoma (BL) is an aggressive form of B-cell non-Hodgkin lymphoma. It may present with a variety of symptoms leading to possible misdiagnosis and delay in treatment. BL is fatal if left untreated, and early diagnosis and treatment can improve prognosis. In this case report, a 3.5-year-old male patient with no known disease had left eyelid swelling and hematuria, and orbital magnetic resonance imaging performed after his admission showed contrast enhancement in the bulbus oculi, and increased uptake in both kidneys (suvmax:9.5) in positron emission tomography. The patient's bone marrow aspiration was normal. There was no involvement in the evaluation of the central nervous system. As a result of kidney biopsy, he was diagnosed with high-grade B-cell lymphoproliferative disease (Ki-67 95-100%, diffuse positivity with CD79a and EBV). Burkitt lymphoma. The treatment of the patient was started in the NHL-BFM 2012 R4 arm. At the end of the treatment, the ocular findings regressed. Burkitt lymphoma may present with different clinical presentations. If appropriate and rapid imaging techniques are used, positive results on survival can be obtained. Our patient is being followed up alive and well.

10.1016/j.htct.2021.10.1001

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Neurological complications after allogeneic hematopoietic stem cell transplantation in children, a single center experience

Pediatric Transplantation (2014)

Fatih Azık Arzu Yazal Erdem Betül Tavil Cengiz Bayram Bahattin Tunç

In this study, we retrospectively examined the data of children who underwent allo-HSCT from HLA-matched family donors. We analyzed the incidence, etiological factors, clinical characteristics, possible reasons, risk factors, and follow-up of neurologic complications. BU-based conditioning regimens were used in most of the cases (n = 62). The median duration of follow-up for the 89 patients was 20 months (range 1-41 months). Eleven percent of transplanted children developed one or more neurological symptoms after HSCT with a median observation time of two months (range -6 days to 18 months). The median age of the four girls and six boys with neurological complication was 13 yr (range 5.3-17.6 yr). Cylosporine A neurotoxicity was diagnosed in five children, four of them were PRES. The rest of complications were BU and lorazepam toxicity, an intracranial hemorrhage, a sinovenous thrombosis, and a transient ischemic attack during extracorpereal photopheresis. No difference was found between groups of neurological complication according to age, gender, diagnosis, hospitalization time, neutrophil and platelet engraftment time, stem cell source, and conditioning regimen, acute and chronic GVHD or VOD. Neurological complication was the cause of death in one patient (1.1%).

Etiology

Total body irradiation

Single Center

10.1111/petr.12265

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Citations (19)

A Newborn with the Kasabach-Merritt Phenomenon and Suspected Kaposiform Hemangioendothelioma

Turkish Journal of Pediatric Disease (2016)

Sevim Ünal Deniz Gönülal Hatice Tatar Aksoy Arzu Yazal Erdem Derya Özyörük

Kasabach–Merritt syndrome

Hemangioendothelioma

Consumptive Coagulopathy

Phenomenon

10.12956/tjpd.2016.248

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Focal Nodulary Hyperplasia of the Liver Due to Congenital Portosystemic Shunt: A Rare Condition Mimicking Hepatocellulary Carcinoma

Journal of Pediatric Hematology/Oncology (2016)

Arzu Yazal Erdem Suna Emir Hacı Ahmet Demir Derya Özyörük İbrahim İlker Çetin

Congenital portosystemic shunts are rare vascular malformations that lead to several complications including liver tumors, pulmonary hypertension, and metabolic encephalopathy. We describe a rare case of a 17-year-old girl with an extrahepatic portosystemic shunt presenting recurrent syncope episodes and a liver mass mimicking hepatocellulary carcinoma.

Portosystemic shunt

Hepatic Encephalopathy

10.1097/mph.0000000000000666

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Citations (7)

Radiotherapy for Renal Rhabdoid Tumor: A Case Report and a Review of Literature

Acta Oncologica Turcica (2018)

Süheyla Aytaç Arslan İpek Pınar Aral Derya Özyörük Suna Emir Zeliha Güzelküçük

ÖZETRenal rhabdoid tumor, çok nadir görülen ve kötü sağkalımla seyreden bir hastalıktır.Radyoterapi bu tumorlerde primer tumore veya cerrahi yatağa, hastalık kontrolü için sıklıkla uygulanmaktadır.Bu vaka takdiminde, 4 aylık renal kitlesi ve yaygın intraabdominal metastazı olan hasta sunulacaktır.Hastaya öncelikle maksimal debulking cerrahi ardından kemoradyoterapi uygulanmıştır

Renal tumor

10.5505/aot.2018.37132

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A CASE DIAGNOSED WITH FOUR DIFFERENT TUMORS

Hematology Transfusion and Cell Therapy (2021)

Fatma Tuba YILDIRIM Derya Özyörük Arzu Yazal Erdem Selma Çakmakçı Neriman Sarı

Chromosomal breakage syndromes are characterized by cancer predisposition. Here we present a 27-month-old female with Fanconi Aplastic Anemia diagnosed with 4 tumors. Imaging showed brain mass causing the shift, liver mass and left kidney mass. She had diagnosed with high grade intracranial tm, wilms tm and hepatocellular ca. Because of refractory pancitopeni, she underwent HSCT. After 2months she developed intracranial embryonal tumor. The patient died with progression. Genetic tests revealed no mutation.

10.1016/j.htct.2021.10.1099

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