Hajime Maeda

Fukushima Medical University

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Co-Authors

Noriyoshi Sawabata

Toyo Institute of Food Technology

Mitsuaki Hosoya

Fukushima Medical University

Hayato Go

Fukushima Medical University

Yukiyasu Takeuchi

Toneyama National Hospital

Shin’ichi Takeda

Kushiro City General Hospital

Masayoshi Inoue

Kyoto Prefectural University of Medicine

Mitsunori Ohta

Osaka Prefectural Medical Center

Koichi Hashimoto

Fukushima Medical University

Meinoshin Okumura

Toneyama National Hospital

Yasunobu Funakoshi

Osaka City General Hospital

Cooperative Institutions

Osaka University

246

The University of Tokyo

147

Kyoto University

106

Fukushima Medical University

Kyushu University

Tohoku University

National Hospital Organization

Toneyama National Hospital

Nagoya University

University of Tsukuba

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Optimal distance of malignant negative margin in excision of nonsmall cell lung cancer: a multicenter prospective study

The Annals of Thoracic Surgery (2004)

Noriyoshi Sawabata Mitsunori Ohta Akihide Matsumura Katsuhiro Nakagawa Hiroshi Hirano

Margin (machine learning)

Resection margin

10.1016/s0003-4975(03)01511-x

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Citations (241)

A monoclonal anti-human platelet antibody: a new platelet aggregating substance

Blood (1985)

M Higashihara Hajime Maeda Y Shibata Shoji Kume T Ohashi

Apyrase

Ristocetin

Adenosine diphosphate

10.1182/blood.v65.2.382.382

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Citations (88)

Comparative study on the effect of ethnicity on wisdom tooth eruption

International Journal of Legal Medicine (2007)

Andreas Olze Piet Van Niekerk Takaki Ishikawa Bao-Li Zhu Ronald Schulz

Tooth eruption

Chronology

Forensic dentistry

10.1007/s00414-007-0171-9

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Citations (124)

Triterpene Galloyl Esters from Edible Acorn of Castanopsis Cuspidata

Natural Product Communications (2016)

Misaki Ogata Yoshinori Saito Yosuke Matsuo Hajime Maeda Takashi Tanaka

Polyphenols of edible acorns of Castanopsis cuspidata were examined and two triterpene galloyl esters were isolated. Based on two-dimensional NMR spectroscopic evidence the structures were determined to be 3,24-di-O-galloyl-2α,3β-23,24-tetrahydroxyolean-12-en-28-oic acid (1) and 3,24-di-O-galloyl- 2α,3β-23,24-tetrahydroxyurs-12-en-28-oic acid (2). The triterpene hexahydroxydiphenoyl esters, which had been found in the leaves, were not detected in the acorns.

Acorn

10.1177/1934578x1601100211

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Citations (3)

Results of surgical intervention for p-stage IIIA (N2) non–small cell lung cancer: Acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe

Journal of Thoracic and Cardiovascular Surgery (2004)

Masayoshi Inoue Noriyoshi Sawabata Shin’ichi Takeda Mitsunori Ohta Yuko Ohno

Mediastinal lymph node

Thoracotomy

Primary tumor

10.1016/j.jtcvs.2003.09.012

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Citations (101)

Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility.

The Journal of Experimental Medicine (1989)

Yuichiro Watanabe Katsushi Tokunaga K. Matsuki F Takeuchi K Matsuta

The association between HLA-DR4 and rheumatoid arthritis (RA) has been established in many ethnic groups. To clarify the determinant of susceptibility to RA, a polymorphic segment of the HLA-DRB gene was amplified in vitro by polymerase chain reaction and analyzed with oligonucleotide probes specific for the HLA-DR4 DNA sequences. A particular sequence encoding amino acids Gln70-Arg71-Arg72-Ala73-Ala74 showed a strong association with RA (p less than 0.005, relative risk 6.0). This amino acid sequence occurs in the DRB molecules with three RA-associated specificities, DR4/Dw14, DR4/Dw15, and DR1. DR4/Dw4, which is common in Caucasian RA patients, has a strikingly similar amino acid sequence Gln70-Lys71-Arg72-Ala73-Ala74 in terms of polarity and charge profiles. Other RA nonassociated sequences differ from this sequence by at least one amino acid substitution that causes the change of the net charge. The composition of amino acid residues at the positions 70-74 may play a crucial role in the pathogenesis of RA.

Sequence (biology)

10.1084/jem.169.6.2263

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Citations (95)

Immunohistochemical investigation of a pulmonary surfactant in fatal mechanical asphyxia

International Journal of Legal Medicine (2000)

Bao-Li Zhu Kaori Shintani‐Ishida Masaki Fujita Hajime Maeda

Atelectasis

Hypoxia

10.1007/s004149900109

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Citations (54)

New prognostic indicator for non‐small‐cell lung cancer, quantitation of thymidylate synthase by real‐time reverse transcription polymerase chain reaction

International Journal of Cancer (2003)

Yasushi Shintani Mitsunori Ohta Hirohisa Hirabayashi H. Tanaka Keiji Iuchi

Abstract Thymidylate synthase (TS) is an enzyme that catalyzes an important DNA biosynthesis process. The gene expression of TS has not been reported in non‐small‐cell lung cancer (NSCLC) patients. To clarify the correlation between TS mRNA levels and clinicopathological features of NSCLC, we examined 70 Stage I and II NSCLC patients for intra‐tumoral expression of TS using TaqMan reverse transcription polymerase chain reaction (RT‐PCR) assay and immunohistochemistry methods. We also investigated the TS promoter 28 bp polymorphism in 48 cancer tissues using PCR amplification of genomic DNA. Lung cancer tissue showed higher TS mRNA levels than normal lung tissue (Mann‐Whitney U ‐tests; p = 0.0020). Further, TS mRNA expression was correlated with immunohistochemical TS expression ( p = 0.029). We obtained 2 different DNA fragments, which indicated triple‐repeat (3R) and double‐repeat (2R) type alleles. Cancer tissues with the 3R/3R genotype showed significantly higher TS mRNA levels as compared to those with other genotypes ( p = 0.0019). The TS genotype was also correlated with immunohistochemical TS expression (χ 2 test; p = 0.0079). The disease‐free survival of the low TS mRNA level group was significantly better than those with high TS mRNA levels (log‐rank test; p = 0.010), however, there were no significant differences found by immunohistochemical evaluation ( p = 0.34) or TS genotype analysis ( p = 0.11). A multivariate analysis revealed that high TS mRNA levels independently contributed to disease‐free survival. The quantitation of TS mRNA levels is clinically more sensitive and useful for determining the prognosis of Stage I and II NSCLC patients than an immunohistochemical evaluation. © 2003 Wiley‐Liss, Inc.

TaqMan

10.1002/ijc.11014

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Citations (77)

[Diagnosis and clinical managements of late complications of severe acute pancreatitis].

PubMed (1990)

Hajime Maeda Tsukasa Tsunoda R Tsuchiya

Source

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Citations (0)

Immunohistochemical investigation of pulmonary surfactant in fatalities related to poisoning

Journal of Toxicology Toxin Reviews (1998)

Bao-Li Zhu Quan Li Shigeki Oritani Kaori Shintani‐Ishida Masaki Fujita

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