Enrique Baca‐García

Universidad Autónoma de Madrid

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Jorge López‐Castromán

Centre Hospitalier Universitaire de Nîmes

María Luisa Barrigón

Universidad Autónoma de Madrid

M. Mercedes Pérez-Rodríguez

Icahn School of Medicine at Mount Sinai

Philippe Courtet

Université de Montpellier

Pilar A. Sáiz

Instituto de Investigación Sanitaria del Principado de Asturias

José de León

Eastern State Hospital

Alejandro Porras‐Segovia

Hospital Universitario Fundación Jiménez Díaz

Hilario Blasco-Fontecilla

Hospital Universitario Puerta de Hierro Majadahonda

Antonio Artés-Rodrı́guez

Universidad Carlos III de Madrid

María A. Oquendo

University of Pennsylvania

Cooperative Institutions

Centro de Investigación Biomédica en Red de Salud Mental

249

Instituto de Salud Carlos III

178

Hospital Universitario Fundación Jiménez Díaz

175

Universidad Autónoma de Madrid

160

Centro de Investigación Biomédica en Red

Columbia University

Universidad Complutense de Madrid

Universitat de Barcelona

Centre for Biomedical Network Research on Rare Diseases

Hospital General Universitario Gregorio Marañón

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Computer Adaptive Test-Substance Use Disorder Scale

PsycTESTS Dataset (2020)

Robert D. Gibbons Margarita Alegrı́a Sheri Lapatin Markle Larimar Fuentes Liting Zhang

10.1037/t77426-000

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Citations (0)

Longitudinal trends in diagnosis at child and adolescent mental health centres in Madrid, Spain

European Child & Adolescent Psychiatry (2012)

Juan J. Carballo Rebeca García Nieto M. Mercedes Pérez-Rodríguez Jorge López‐Castromán Hilario Blasco‐Fontecilla

Child Development

10.1007/s00787-012-0322-5

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Citations (102)

An Exploratory Study of the Relationship between Diverse Life Events and Specific Personality Disorders in a Sample of Suicide Attempters

Journal of Personality Disorders (2010)

Hilario Blasco-Fontecilla Enrique Baca‐García Paul R. Duberstein M. Mercedes Pérez-Rodríguez Kanita Dervic

Personality disorder (PD) increases risk for suicidal behavior. Certain life events (LE) can precipitate suicidal behaviors in patients with PD. A fundamental question is whether specific combinations of LE and PD increase suicidal risk. Four hundred forty-six suicide attempters (SA) were recruited from emergency rooms. We used a healthy control group (n = 515) to identify the best cut-off point for the instrument used to diagnose PD. We used the DSM-IV version of the International Personality Disorder Questionnaire—Screening Questionnaire, the Mini International Neuropsychiatric Interview, and the Social Adjustment Scale to assess PD, Axis I disorders, and LE, respectively. After controlling for Axis I disorders, we found that "Death of spouse" preceded suicidal acts in those with antisocial PD (FET p = 0.024) and patients with narcissistic PD attempted suicide after being Fired at work (FET p = 0.002), among others. Our data suggest the presence of particular LE-PD associations in suicide attempters. Some LE-PD relationships appear independent of Axis I disorders in suicide attempters. This may offer a basis for specific targeted therapies or prevention programs aimed at decreasing suicidal risk.

Spouse

Mini-international neuropsychiatric interview

10.1521/pedi.2010.24.6.773

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Citations (59)

Psychiatrists’ and Psychologists’ Practice Patterns

The Journal of Nervous and Mental Disease (2013)

Rebeca García Nieto Jorge López‐Castromán Hilario Blasco-Fontecilla Consuelo Morant Ginestar Enrique Baca‐García

Important differences in clinical practice exist between psychiatrists and psychologists. However, there is scarce information on the characteristics of patients receiving treatment from these two groups of professionals. We examined the diagnoses assigned to the patients who received treatment from psychiatrists and psychologists in outpatient settings of Madrid, Spain, from 1980 to 2008. The psychologists were more likely to see anxiety-related disorders, whereas the psychiatrists tended to see disorders with a more prominent biological underpinning, such as schizophrenia or bipolar disorder. The profile of the patients seen by the psychologists is different from that of the psychiatrists. Disorders whose development is more related to distress were usually treated by the psychologists, whereas disorders with a more prominent biological underpinning were usually treated by the psychiatrists. In addition, the dramatic increase in the diagnosis of adjustment disorder might be related to the increasing "psychologization" and "medicalization" of the difficulties of everyday life.

Medicalization

Underpinning

10.1097/nmd.0000000000000054

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Citations (3)

Shift in Social Media App Usage During COVID-19 Lockdown and Clinical Anxiety Symptoms: Machine Learning–Based Ecological Momentary Assessment Study (Preprint)

Jihan Ryu Emese Sükei Agnes Norbury Shelley H. Liu Juan José Campaña-Montes

BACKGROUND Anxiety symptoms during public health crises are associated with adverse psychiatric outcomes and impaired health decision-making. The interaction between real-time social media use patterns and clinical anxiety during infectious disease outbreaks is underexplored. OBJECTIVE We aimed to evaluate the usage pattern of 2 types of social media apps (communication and social networking) among patients in outpatient psychiatric treatment during the COVID-19 surge and lockdown in Madrid, Spain and their short-term anxiety symptoms (7-item General Anxiety Disorder scale) at clinical follow-up. METHODS The individual-level shifts in median social media usage behavior from February 1 through May 3, 2020 were summarized using repeated measures analysis of variance that accounted for the fixed effects of the lockdown (prelockdown versus postlockdown), group (clinical anxiety group versus nonclinical anxiety group), the interaction of lockdown and group, and random effects of users. A machine learning–based approach that combined a hidden Markov model and logistic regression was applied to predict clinical anxiety (n=44) and nonclinical anxiety (n=51), based on longitudinal time-series data that comprised communication and social networking app usage (in seconds) as well as anxiety-associated clinical survey variables, including the presence of an essential worker in the household, worries about life instability, changes in social interaction frequency during the lockdown, cohabitation status, and health status. RESULTS Individual-level analysis of daily social media usage showed that the increase in communication app usage from prelockdown to lockdown period was significantly smaller in the clinical anxiety group than that in the nonclinical anxiety group (F<sub>1,72</sub>=3.84, <i>P</i>=.05). The machine learning model achieved a mean accuracy of 62.30% (SD 16%) and area under the receiver operating curve 0.70 (SD 0.19) in 10-fold cross-validation in identifying the clinical anxiety group. CONCLUSIONS Patients who reported severe anxiety symptoms were less active in communication apps after the mandated lockdown and more engaged in social networking apps in the overall period, which suggested that there was a different pattern of digital social behavior for adapting to the crisis. Predictive modeling using digital biomarkers—passive-sensing of shifts in category-based social media app usage during the lockdown—can identify individuals at risk for psychiatric sequelae.

10.2196/preprints.30833

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[Assessment of clinical assessment reliability among researchers of a multicenter clinical trial].

PubMed (1999)

Enrique Baca‐García Carmen Díaz-Sastre F. Rico Sáiz Ruiz J

Interater agreement is a main aspect in the planning and conducting a clinical trial. The objective of this study is to show the application of assessing levels of interexaminer's agreement when multiple ratings are made on a single subject as an efficient method of evaluating the interater's reliability in planning a multicenter clinical trial.39 psychiatrist assessed videotape of a patient with depression. The use of any reliability statistics is failed in the analysis of multiple independent ratings of a single subject since we used the methodology proposed by Cichetti et al. This method is able to identify raters whose ratings differ significantly from the average ratings and is sensitive for different levels of agreement.Interarter agreement was between good and excellent. The raters show an adequate agreement in total and items scores.The design proposed permits evaluate the interater agreement in an efficient way (only in one session).

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Diurnal Variability of Orofacial Dyskinetic Movements

Pharmacopsychiatry (1999)

Enrique Baca‐García Joseph K. Stanilla C. Büchel Wagner F. Gattaz José de León

Instrumental methods to measure tardive dyskinesia (TD) have been introduced in the last few years to try to eliminate the differences in inter-rater reliability. After eliminating variations attributed to the use of different raters, it is clear that TD frequently shows fluctuations in severity contributing to a low test-retest reliability. In the present study the diurnal variability of dyskinetic movements was explored by a computerized technique using digital imaging processing to measure orofacial movements.Ten patients with persistent tardive dyskinesia were assessed three times a day once a week for four consecutive weeks.Four patients had significant diurnal variations in the severity of dyskinetic movements and six did not have significant variations. The period of time between waking and the assessment, the severity of dyskinetic movements, and smoking were significantly different between these two groups.Diurnal variations, particularly in relation to sleeping and smoking patterns, may need to be taken into account during longitudinal studies of tardive dyskinesia.

Tardive dyskinesia

Diurnal temperature variation

10.1055/s-2007-979195

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Citations (14)

Comparación de la discapacidad entre trastornos mentales graves y comunes usando la escala WHODAS 2.0

Revista de Psiquiatría y Salud Mental (2021)

Elena Hernando-Merino Enrique Baca‐García María Luisa Barrigón

10.1016/j.rpsm.2021.08.004

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Citations (2)

Relationship between Neurocognition, Social Cognition, and Metacognition and Suicidal Behavior in Recent-Onset Psychosis

Aina Sastre-Buades Irene Caro‐Cañizares Susana Ochoa Ester Lorente Ana Barajas

Suicidal behavior (SB) is common in first-episode psychosis (FEP), and cognitive impairment has also been described in psychosis, which may also include cognitive insight (CI) as part of metacognition. Despite well-established risk factors for SB in psychosis, the role of cognition and insight remain unclear. This study aimed to explore the relationship between history of SB and cognition in recent-onset FEP, distinguishing between neurocognition, social cognition, and metacognition, and including CI as a metacognitive variable. The sample consisted of 190 participants with recent-onset FEP recruited from two multicentric studies. Two groups were formed based on presence/absence of a history of SB. Demographic, clinical, and cognitive data were compared by group. Multivariate analysis of variables found to be statistically significant (p<0.05) was performed by applying a logistic regression model. No differences were found regarding demographic, clinical, and neurocognitive variables except for alcohol use (43.1%; X2=4.12; p=0.042), attributional style (externalizing bias) (1.15 ± 3.94; t=2.07; p=0.041), theory of mind (ToM) (1.73 ± 0.22; t=2.04; p=0.043), JTC (23.3%; X2=0.94; p=0.015), and CI (18.18 ± 4.87; t=-3.16; p=0.002). When logistic regression was applied, externalizing bias (OR 0.847; 95% CI 0.734-0.977; p=0.023) remained statistically significant, whereas ToM (OR 6.694; 95% CI 0.965-46.434; p=0.054) and JTC (OR 3.615; 95% CI 0.980-13.330; p=0.054) tended toward significance. In recent-onset psychosis, history of SB was not associated with neurocognitive functioning. However, extremely low externalizing bias was found to be related to history of SB. Better ToM, presence of JTC, and higher CI appeared to be linked to previous SB.

Neurocognitive

10.2139/ssrn.4093805

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CYP2D6Polymorphism and Mental and Personality Disorders in Suicide Attempters

Journal of Personality Disorders (2013)

Hilario Blasco-Fontecilla Eva Peñas‐Lledó Concepción Vaquero‐Lorenzo Pedro Dorado Jerónimo Saiz‐Ruiz

Prior studies on the association between the CYP2D6 polymorphism and suicide did not explore whether mental and personality disorders mediate this association. The main objective of the present study was to test an association between CYP2D6 polymorphism and mental and personality disorders among suicide attempters. The MINI and the DSM-IV version of the International Personality Disorder Examination Screening Questionnaire were used to diagnose mental and personality disorders, respectively, in 342 suicide attempters. Suicide attempters were divided into four groups according to their number of CYP2D6 active genes (zero, one, and two or more). Differences in mental and personality disorders across the four groups were measured using linear-by-linear association, chi square-test, and 95% confidence intervals. Suicide attempters carrying two or more active CYP2D6 genes were more likely to be diagnosed with at least one personality disorder than those with one or zero CYP2D6 active genes.

Association (psychology)

10.1521/pedi_2013_27_080

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Citations (5)