A patient with acute mixed myelocytic and lymphocytic leukemia is reported. The patient showed two populations of malignant myeloid and lymphoid cells with predominance of myeloid lineage. According to the present knowledge, it is hypothesized that its origin is at a pluripotent transformed stem cell which has the capability of differentiating through myeloid and lymphoid lineages. Its maturation is arrested at certain level, thus raising two monoclonal populations simultaneously in the same patient. The treatment should be combined with drugs used in acute myeloblastic and lymphoblastic leukemia. The response to chemotherapy is generally poor.

Lineage (genetic)

Acute myeloblastic leukemia

Myelocytic leukemia

Acute lymphocytic leukemia

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Theoretical Considerations of Laminar Flame Speed as a Function of Initial Conditions and Basic Kinetic Properties with Respect to the Safety Problem

能源与动力工程：英文版 (2012)

Jorge Yáñez Mike Mike  Kuznetsov Alexei

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Harmonic Analysis of Radon Filtrations for Sn and Its q-Analogue GLn（q）

代数集刊：英文版 (2015)

Francisca Yáñez

Harmonic

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Electronic dispersion pre-compensation using a directly modulated laser at 10.7-Gb/s

European Conference on Optical Communication (2011)

Karar Yáñez Jiang Cartledge Harley

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DDE-induced apoptosis in children exposed to the DDT metabolite.

The Science of The Total Environment (2006)

Perez-Maldonado Athanasiadou Yáñez Gonzalez-Amaro

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Smoking effects on prolactin levels at pregnancy and lactation

The FASEB Journal (1997)

Gabriela Salazar Yáñez Jorge Andrés Ahumada Ahumada MARIA SERÓN- FERRÉ M. Seron Vio

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A NEW LEVEL OF REGULATION IN GLUCONEOGENESIS: METABOLIC STATE MODULATES THE INTRACELLULAR LOCALIZATION OF ALDOLASE B AND ITS INTERACTION WITH LIVER FRUCTOSE-1,6-BISPHOSPHATASE Droppelmann

Sáez Asenjo Yáñez Garcia-Rocha

We observed that glucose, insulin, glucagon and adrenaline differentially modulate the intracellular distribution of aldolase-B and FBPase-1. Interestingly, the in vitro protein-protein interaction analysis between aldolase-B and FBPase-1 showed a specific and regulatable interaction between them, whereas aldolase-A (muscle isozyme) and FBPase-1 showed no interaction. The affinity of the aldolase-B and FBPase-1 complex was modulated by intermediate metabolites, but only in the presence of K. We observed a decreased association constant in the presence of AMP, fructose-2,6-bisphosphate, fructose-6-phosphate and inhibitory concentrations of fructose-1,6-bisphosphate. Conversely, the association constant of the complex increased in the presence of dihydroxyacetone phosphate and non-inhibitory concentrations of fructose-1,6-bisphosphate. Notably, in vivo FRET studies confirmed the interaction between aldolase-B and FBPase-1. Also, the co-expression of aldolase-B and FBPase-1 in cultured cells suggested that FBPase-1 guides the cellular localization of aldolaseB.

Aldolase B

Fructose 1,6-bisphosphatase

Phosphofructokinase 2

Gluconeogenesis

Fructose 2,6-bisphosphate

Fructolysis

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