O. O. Pogrebnyak

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Ya. V. Korost

Bogomolets National Medical University

I.Yu. Golovach

Kyiv City Clinical Oncology Center

V. V. Lotushko

O. M. Barna

V. S. Pekhenko

O. O. Alifer

Lionel S. Zinko

Taras Shevchenko National University of Kyiv

ІП

І. П. Катеренчук

Poltava State Medical University

OМ

O. М. Barna

Bogomolets National Medical University

L. O. Matyash

Cooperative Institutions

Bogomolets National Medical University

Taras Shevchenko National University of Kyiv

Kyiv City Clinical Oncology Center

Ukrainian Medical Stomatological Academy

Shupyk National Healthcare University of Ukraine

Clinical Hospital No. 8

Poltava State Medical University

The George Institute for Global Health

University College London

Enamine (Ukraine)

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Вплив вазостату і кораргіну на показники вазорегулювальної функції судинного ендотелію у хворих на ішемічну хворобу серця, асоційовану з цукровим діабетом 2 типу

І. П. Катеренчук Олена Олександрівна Погребняк І. П. Катеренчук O. O. Pogrebnyak

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Frailty: Focus on Regenerative Medicine

Medicine of Ukraine (2024)

O. М. Barna Ya. V. Korost O. O. Pogrebnyak V. O. Maleeva

Frailty, as a specific condition of increased vulnerability and deterioration of general health associated with aging in the elderly, is an emerging problem worldwide with serious implications for clinical practice and public health. Frailty increases the risk of falls, hospitalization, disability, and death. Muscle aging is associated with progressive loss of skeletal muscle mass and function. Loss of muscle mass with age can be related to muscle fiber atrophy and loss of muscle fibers. With increasing human age, remodeling of bone tissue becomes more prone to slow and steady loss of bone mass, which is primarily associated with loss of bone formation by osteoblasts. Recent preclinical and clinical studies have confirmed the safety of mesenchymal stem/stromal cells (MSCs) in the treatment of frailty. MSCs are attracted to sites of damage where they act to reduce inflammation and promote cell repair. Thus, there is an assumption that frailty can be treated with cell therapy

Regenerative Medicine

10.37987/1997-9894.2024.2(278).306660

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Underestimated aspects of metformin in the prevention and treatment of prediabetes and type 2 diabetes in the light of modern recommendations

Medicine of Ukraine (2023)

O. O. Pogrebnyak

The article discusses the pathogenesis, methods of diagnosis, prevention, and treatment of insulin resistance, prediabetes, and type 2 diabetes. According to international recommendations, the first-line therapy for type 2 diabetes is metformin and lifestyle modification (correction of excess weight, regular physical activity), which have shown high effectiveness in large-scale clinical studies.

Prediabetes

10.37987/1997-9894.2023.1(267).281395

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Evaluation of the bone tissue state in terms of ultrasound densitometry in the gender aspect (SCELET study)

Medicine of Ukraine (2018)

O. M. Barna I.Yu. Golovach O. O. Pogrebnyak Ya. V. Korost V. S. Pekhenko

Osteoporosis – a systemic disease of the skeleton, characterized by a reduction in bone mass and a deterioration in the quality of bone tissue.This results in bone fragility and increased risk of fractures. There are gender differences in the rate of development and severity of osteoporosis. In men, bone remodeling develops less intensively due to the lack of sex hormones comparable to women, which is the cause of postmenopausal osteoporosis. Loss of bone mass in men occurs linearly and gradually for decades.The aim of the study. The purpose of the research of SCELET (State of the BonE tissue of the Ukrainian popuLation: Epidemiological Trends) was to assess the status of bone tissue among the Ukrainian population and compare the indicators in different regions in the gender aspect.Materials and methods. The SKELET study was based on population surveys in the major cities of Ukraine – Kyiv, Kharkiv, Odessa, Lviv. A total of densitometric survey was carried out 986 people, of which 84.6 % – women, the average age of all surveyed – 49.2±15.32 years.Results. Among all the women surveyed from four cities of Ukraine (Kyiv, Odessa, Lviv, Kharkiv) had bone mineral density (BMD), regardless of age, 45.54 % for normal BMD, osteopenia was found to be 47.43 % and osteoporosis was 7.03 %. The highest frequency of osteoporosis was found among women in Kyiv.Conclusions. A useful tool for screening osteoporosis is ultrasonic densitometry. In the SKELET study among the population of different cities of Ukraine, the highest risk of bone fractures among women in Kyiv was found.

Densitometry

Osteopenia

Bone tissue

Bone remodeling

10.37987/1997-9894.2018.3(219).198454

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Silica Adsorbed Indicator System «La(III)-Alizarincomplexone» for Fluoride Determination in Saliva

METHODS AND OBJECTS OF CHEMICAL ANALYSIS (2015)

Anastasia S. Paustovska Lionel S. Zinko Olga A. Zaporozhets V. Nakonechna O. O. Pogrebnyak

10.17721/moca.2015.53-60

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Treatment of Community-acquired pneumonia in patients with chronic renal failure (clinical case)

Medicine of Ukraine (2017)

O. O. Pogrebnyak О. К. Kaplunovsky

Treatment of Community-acquired pneumonia remains an actual problem in modern medicine, especially in patients with concomitant pathology of internal organs. In particular, this applies to patients with chronic renal failure, which often remain in conditions of subureemia. On the background of the latter, the other concomitant conditions and sufferings often develop, such as uremic pneumonitis, chronic hyperhydration of the pulmonary tissue, the syndrome of night apnoea and hypoxemia, associated with the hemodialysis sessions. All this creates a favorable background for the additional bacterial infection and the development of Community-acquired pneumonia. The sooner the diagnosis of pneumonia is established, the earlier the ethiotropic treatment hasstarted, the more effective the treatment is in outpatient settings. In the clinical case, the efficacy and appropriateness of administration of Rovamycin (spiramycin) as a medication for antibiotic therapy in the treatment of Community-acquired pneumonia in patients with chronic renal failure has been proven.

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Chronic renal failure

Chronic respiratory failure

Pneumonitis

10.37987/1997-9894.2017.9-10(215-6.222474

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Components of anthelicobacter therapy: the role of bismuth preparations

Medicine of Ukraine (2020)

L. O. Matyash N. V. Snigir O. O. Pogrebnyak

Treatment of peptic ulcer involves a comprehensive principle, due to the etiological infectious factor that leads to the lesion of the gastric mucosa. H. pylori – bacterium, with high virulence, causes the development of active gastritis, which can subsequently progress to atrophic gastritis, peptic ulcer, and even gastric adenocarcinoma or MALT-lymphoma. The current view of the medical community on treatment in the context of increasing antibiotic resistance of H. pylori has made it possible to identify major treatment regimens, among which one of the best options is triple therapies: a combination of a proton pump inhibitor, antibiotics and bismuth preparations. The latter, in addition to directly antihelicobacter action also has a reparative effect on the affected gastric mucosa, providing rapid healing of peptic ulcer defects. Among modern representatives of the preparation of bismuth, the best proved the drug De-Nol®, which, when compared with generic bismuth preparations, favorably differed in quality of chemical composition, uniformity of structure, endurance under different pH levels. Anti-Helicobacter pacemaker therapy in which De-Nol® is present has high efficacy and safety, even with long-term treatment.

Peptic

Etiology

10.37987/1997-9894.2020.1(237).214174

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Evaluation of the bone tissue state in terms of ultrasound densitometry in the age aspect (SCELET research)

Medicine of Ukraine (2017)

O. M. Barna I.Yu. Golovach O. O. Pogrebnyak Ya. V. Korost V. S. Pekhenko

According to WHO experts, osteoporosis is fourth in prevalence after cardiovascular, oncological and endocrine diseasesAim of the study. The purpose of the research of SCELET (State of the BonE tissue of the Ukrainian popuLation: Epidemiological Trends) was to assess the bone tissue state among the Ukrainian population and compare the indicators in different regions in the age aspect.Materials and methods. The research of SKELET was based on population surveys in the major cities of Ukraine – Kyiv, Kharkiv, Odessa, Lviv. A total of densitometric examination was carried out 986 people, 84.6% – women, the average age of all examined – 49.2 ± 15.32 years. All examined were divided into 3 groups by age – ˂ 40 years, 41-55 years, 55 years old. Results. In the SCELET study, among half of all the examined persons in four cities of Ukraine, bone mineral density (BMD), regardless of age, had normal BMD, osteopenia was found in 43%, and osteoporosis in 7%. The highest frequency of osteoporosis was found among the population of Kyiv in all age groups. Osteopenia in the age group up to 40 years was mostly detected among the citizens of Kyiv, and at the age over 55 years among the inhabitants of the Kharkiv.Conclusions. Osteoporosis is a systemic metabolic disease of the skeleton, which progresses with age among the Ukrainian population. Timely diagnosis and prevention of this condition will help to prevent its epidemic in our country and to prevent the medical and social consequences.

Osteopenia

Densitometry

Ukrainian

Age groups

10.37987/1997-9894.2017.8(214).222448

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