// Vincenza Granata 1 , Roberta Fusco 1 , Orlando Catalano 1 , Benedetta Guarino 1 , Francesco Granata 2 , Fabiana Tatangelo 3 , Antonio Avallone 4 , Mauro Piccirillo 5 , Raffaele Palaia 5 , Francesco Izzo 5 , Antonella Petrillo 1 1 Department of Radiology, "Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli", Naples, I-80131, Italy 2 Department of Civil and Mechanical Engineering, "Università degli Studi di Cassino e del Lazio Meridionale", Cassino 03043, Italy 3 Departement of Pathology, "Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli", Naples, I-80131, Italy 4 Department of Gastrointestinal Oncology, "Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli", Naples, I-80131, Italy 5 Department of Hepatobiliary Surgical Oncology, "Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli", Naples, I-80131, Italy Correspondence to: Roberta Fusco, email: r.fusco@istitutotumori.na.it Keywords: HCC, magnetic resonance imaging, diffusion weighted imaging, histologic grade Received: July 06, 2016 Accepted: September 29, 2016 Published: October 15, 2016 ABSTRACT Purpose: To assess the correlation between DWI diffusion parameters obtained using Intravoxel Incoherent Motion Method (IVIM) and histological grade of Hepatocellular carcinoma (HCC). Results: According to Edmondson-Steiner grade lesions were classified with grade 1 (14), grade 2 (30), grade 3 (18), and grade 4 (0). Apparent Diffusion Coefficient (ADC), perfusion fraction (fp), tissue diffusion coefficient (Dt) median values were statistically different in HCC groups with 1, 2, 3 histological grade (p<0.001). A significant correlation was reported between ADC, fp, Dt and histologic grade respectively of 0.687, 0.737 and 0.674. Receiver operating characteristic (ROC) analysis demonstrated that an ADC of 2.11x10-3 mm2/sec, an fp of 47.33% and an Dt of 0.94x10-3 mm 2 /sec were the optimal cutoff values to differentiate high histological grade (3) versus low histological grade (1-2), with a sensitivity and specificity for ADC of 100% and 100%, for fp of 100% and 89%, for Dt of 100% and 74%, respectively. Material and Methods: A retrospective approved study was performed including 34 patients with 62 HCCs. IVIM was performed to obtain ADC, fp, pseudo-diffusion coefficient (Dp), Dt coefficients. Kruskal Wallis, Spearman Correlation Coefficient, ROC analysis were performed. Conclusions: ADC and IVIM-derived fp showed significantly better diagnostic performance in differentiating high-grade from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.
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