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Leo Anderson Meira-Martins

Universidade Federal do Rio Grande do Sul

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Adriano Martimbianco de Assis

Universidade Católica de Pelotas

Jussemara Souza da Silva

Instituto de Infectologia Emílio Ribas

Guilhian Leipnitz

Universidade Federal do Rio Grande do Sul

Aline Longoni

Universidade Católica de Pelotas

Diogo O. Souza

Universidade Federal do Rio Grande do Sul

Yasmine Nonose

New York Stem Cell Foundation

Mateus Grings

Oroboros Instruments (Austria)

Janaína Kolling

Universidade Federal do Rio Grande do Sul

Leandro Zafalon Pieper

Universidade Católica de Pelotas

Carlos‐Alberto Gonçalves

Universidade Federal do Rio Grande do Sul

Cooperative Institutions

Universidade Federal do Rio Grande do Sul

Universidade Federal de Ciências da Saúde de Porto Alegre

Universidade Católica de Pelotas

Universidade Federal do Rio Grande

Universidade Federal de Santa Catarina

Universidade Luterana do Brasil

Instituto Nacional de Ciência e Tecnologia em Excitotoxicidade e Neuroproteção

Hospital de Clínicas de Porto Alegre

National Council for Scientific and Technological Development

Instituto de Saúde

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Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats

Frontiers in Molecular Neuroscience (2020)

Pedro Arend Guazzelli Giordano Fabricio Cittolin‐Santos Leo Anderson Meira-Martins Mateus Grings Yasmine Nonose

Acute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic dysfunction and energy metabolism impairment may synergistically interact, playing a role in the development of HE. The purpose of the present study is to investigate early alterations in redox status, energy metabolism and astrocytic reactivity of rats submitted to ALF. Adult male Wistar rats were submitted either to subtotal hepatectomy (92% of liver mass) or sham operation to induce ALF. Twenty-four hours after the surgery, animals with ALF presented higher plasmatic levels of ammonia, lactate, ALT and AST and lower levels of glucose than the animals in the sham group. Animals with ALF presented several astrocytic morphological alterations indicating astrocytic reactivity. The ALF group also presented higher mitochondrial oxygen consumption, higher enzymatic activity and higher ATP levels in the brain (frontoparietal cortex). Moreover, ALF induced an increase in glutamate oxidation concomitant with a decrease in glucose and lactate oxidation. The increase in brain energy metabolism caused by astrocytic reactivity resulted in augmented levels of reactive oxygen species (ROS) and Poly [ADP-ribose] polymerase 1 (PARP1) and a decreased activity of the enzymes superoxide dismutase and glutathione peroxidase (GSH-Px). These findings suggest that in the early stages of ALF the brain presents a hypermetabolic state, oxidative stress and astrocytic reactivity, which could be in part sustained by an increase in mitochondrial oxidation of glutamate.

10.3389/fnmol.2019.00327

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Citations (9)

1,25-Dihydroxyvitamin D3 prevents deleterious effects of homocysteine on mitochondrial function and redox status in heart slices

Nutrition Research (2017)

Aline Longoni Janaína Kolling Cassiana Siebert João Paulo dos Santos Jussemara Souza da Silva

10.1016/j.nutres.2017.01.007

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Guanosine enhances glutamate uptake and oxidation, preventing oxidative stress in mouse hippocampal slices submitted to high glutamate levels

Brain Research (2020)

Yasmine Nonose Leandro Zafalon Pieper Jussemara Souza da Silva Aline Longoni Rodrigo Vieira Apel

Excitotoxicity

Slice preparation

10.1016/j.brainres.2020.147080

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Citations (6)