Karin Fehsel

Heinrich Heine University Düsseldorf

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Victoria Kolb-Bachofen

Heinrich Heine University Düsseldorf

V. Kolb‐Bachofen

Heinrich Heine University Düsseldorf

Christian Luckhaus

Ruhr University Bochum

A. Klimke

Heinrich Heine University Düsseldorf

U. Henning

Heinrich Heine University Düsseldorf

Hubert Kolb

Heinrich Heine University Düsseldorf

K D Kröncke

Heinrich Heine University Düsseldorf

Stefan Löffler

Sana Klinikum Offenbach

Christoph V. Suschek

Heinrich Heine University Düsseldorf

Thomas Ruzicka

Ludwig-Maximilians-Universität München

Cooperative Institutions

Heinrich Heine University Düsseldorf

111

Düsseldorf University Hospital

Heidelberg University

Ludwig-Maximilians-Universität München

Leibniz Institute of Environmental Medicine

Klinik und Poliklinik für Psychiatrie und Psychotherapie

Johannes Gutenberg University Mainz

Deutsches Diabetes-Zentrum e.V.

German Center for Diabetes Research

University of Cologne

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Nitric Oxide: Cytotoxicity versus Cytoprotection— How, Why, When, and Where?

Nitric Oxide (1997)

Klaus-D. Kröncke Karin Fehsel Victoria Kolb-Bachofen

Cytoprotection

10.1006/niox.1997.0118

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Citations (510)

Sex‐dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long‐term clozapine and haloperidol medication

Brain and Behavior (2020)

M Bouvier Karin Fehsel Andrea Schmitt Eva Meisenzahl‐Lechner Wolfgang Gäebel

Abstract Objective Sex‐dependent disturbances of peripheral glucose metabolism are known complications of antipsychotic drug treatment. The influence of long‐term clozapine and haloperidol medication on hypothalamus, maintaining aspects of internal body homeostasis, has not yet been completely clarified. Methods After puberty, male and female Sprague Dawley rats were fed orally with ground pellets containing haloperidol (1 mg/kgBW/day) or clozapine (20 mg/kgBW/day) for 12 weeks. The hypothalamic protein expression of dopamine receptors D2R and D4R, melanocortin receptor MC4R, and glucose transporters Glut1 and Glut3 was examined. Glucose, glycogen, lactate, and pyruvate levels were determined, also malondialdehyde equivalents as markers of oxidative stress. Results D2R expression was increased in the male haloperidol and clozapine group but decreased in females medicated with clozapine. D4R expression was upregulated under clozapine medication. While females showed increased Glut1, Glut3 was elevated in both male and female clozapine‐medicated animals. We found no changes of hypothalamic malondialdehyde, glycogen, and MC4R. Hypothalamic lactate was elevated in the female clozapine group. Conclusion Clozapine sex‐dependently affects the expression of D2R, Glut1, and Glut3. The upregulation of the glucose transporters indicates glucose deprivation in the endothelial cells and consequently in astrocytes and neurons. Increased hypothalamic lactate in females under clozapine points to enhanced glycolysis with a higher glucose demand to produce the required energy. Haloperidol did not change the expression of the glucose transporters and upregulated D2R only in males.

GLUT3

10.1002/brb3.1694

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NO as a Physiological Signal Molecule that Triggers Thymocyte Apoptosis

Advances in experimental medicine and biology (1996)

Karin Fehsel Klaus‐Dietrich Kröncke Victoria Kolb-Bachofen

Thymocyte

10.1007/978-1-4757-9480-9_26

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Citations (4)

Subject Index Vol. 26, 2003

Kidney & Blood Pressure Research (2003)

Leszek Rutkowski Tomas Lenz Thomas Haak Joanna Malek Hermann‐Josef Gröne

10.1159/000074830

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Citations (1)

Lithium evoked DNA strand breaks and apoptosis in IMR-32 cells are independent of P53 and iNOS

European Psychiatry (1998)

Stefan Löffler Karin Fehsel U. Henning A. Klimke

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Content (measure theory)

10.1016/s0924-9338(99)80670-1

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Möglichkeiten der HLA-Diagnostik beim Typ I-Diabetes

Zusammenarbeit von Klinik und klinischer Chemie (1989)

Helmut J. Kolb Karin Fehsel

10.1007/978-3-642-83748-7_8

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Effects of the Genetic Polymorphisms of the Renin-Angiotensin System on Focal Segmental Glomerulosclerosis

Kidney & Blood Pressure Research (2003)

Y. Luther Christos Bantis Katrin Ivens Karin Fehsel V. Kolb-Bachhofen

We analyzed the influence of angiotensin-converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and angiotensin-II-type-1 receptor (AT1R) A1166C genetic polymorphisms on the clinical course of focal segmental glomerulosclerosis (FSGS).This study consisted of 71 patients with nephrotic syndrome due to biopsy proven FSGS and 100 healthy controls. According to the slope of the reciprocal serum creatinine (1/Cr, >or= or <-0.1 dl x mg(-1) x year(-1)) patients were classified into group A (slow progressors, n = 50) and group B (fast progressors, n = 21). Genotyping was performed using polymerase chain reaction (PCR).There were no relevant differences in the allele frequencies of the investigated polymorphisms between patients with FSGS and controls. Patients carrying the T- allele of the AGT polymorphism required a larger number of antihypertensive agents (MM: 1.35 +/- 1.0 vs. MT/TT: 2.0 +/- 1.2, p < 0.05). The ACE-ID/DD genotypes were more frequently found in patients with fast progression (group A: II: 38.0%, ID/DD: 62.0% vs. group B: II: 14.3%, ID/DD: 85.7%, p < 0.05). The AT1R-A1166C polymorphism was not associated with any of the parameters studied.The course of FSGS is in part genetically determined by polymorphisms of the renin-angiotensin-system. The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.

10.1159/000073939

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Citations (25)

The atypical antipsychotic clozapine sensitizes for granulocyte apoptosis

Schizophrenia Research (2000)

A. Klimke Stefan Löffler U. Henning V. Kolb‐Bachofen Karin Fehsel

Pedunculopontine nucleus

Reticular activating system

Subthalamic Nucleus

10.1016/s0920-9964(00)90905-8

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Citations (1)

Nitric Oxide Generation during Cellular Metabolization of the Diabetogenic N-Mefhyl-N-Nitroso-Urea Streptozotozin Contributes to Islet Cell DNA Damage

Biological Chemistry Hoppe-Seyler (1995)

K D Kröncke Karin Fehsel A Sommer Maria-L. Rodriguez V. Kolb‐Bachofen

Article Nitric Oxide Generation during Cellular Metabolization of the Diabetogenic N-Mefhyl-N-Nitroso-Urea Streptozotozin Contributes to Islet Cell DNA Damage was published on January 1, 1995 in the journal Biological Chemistry (volume 376, issue 3).

Omega-N-Methylarginine

10.1515/bchm3.1995.376.3.179

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Citations (227)

Clozapine enhances differentiation of adipocyte progenitor cells

Molecular Psychiatry (2006)

Karsten Hemmrich C. Gummersbach Norbert Pallua Christian Luckhaus Karin Fehsel

Sibutramine

10.1038/sj.mp.4001892

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Citations (31)