Sandra Santos‐Martínez

Hospital Clínico Universitario de Valladolid

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Ignacio J. Amat‐Santos

Centro de Investigación Biomédica en Red

José Alberto San Román

Hospital Clínico Universitario de Valladolid

Luis Nombela‐Franco

Instituto de Investigación Sanitaria del Hospital Clínico San Carlos

José Raúl Delgado-Arana

Hospital Base Guillermo Almenara Irigoyen

Alfredo Redondo

Junta de Castilla y León

Tania Rodríguez‐Gabella

Hospital Clínico Universitario de Valladolid

Ana Serrador

Centro de Investigación Biomédica en Red

Hipólito Gutiérrez

Hospital Clínico Universitario de Valladolid

Carlos Baladrón

Hospital Clínico Universitario de Valladolid

Alejandro Barrero

Hospital Clínico Universitario de Valladolid

Cooperative Institutions

Centro de Investigación en Red en Enfermedades Cardiovasculares

130

Centro de Investigación Biomédica en Red

115

Instituto de Salud Carlos III

Hospital Clínico San Carlos

Hospital Clínico Universitario de Valladolid

Institute of Cardiology

Universidad Complutense de Madrid

Universitat Autònoma de Barcelona

Instituto de Investigación Sanitaria del Hospital Clínico San Carlos

Complexo Hospitalario Universitario A Coruña

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The mystery of the Dragon�s tail solved by 3D reconstruction

REC interventional cardiology (English Edition) (2023)

Sandra Santos‐Martínez Miguel Leiva-Gordillo Ricardo García-Belenguer Paula Tejedor-Viñuela and Pedro Morillas-Blasco

10.24875/recice.m23000385

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Seguridad y viabilidad del acceso radial para intervenciones coronarias percutáneas de oclusiones totales crónicas

Revista Española de Cardiología (2022)

Alejandro Diego‐Nieto Jean C. Núñez Gema Miñana Ignacio J. Amat‐Santos Pablo Salinas-Sanguino

10.1016/j.recesp.2022.05.021

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Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de COVID-19./ [Risk factors for in-hospital mortality in patients with acute myocardial infarction during the COVID-19 outbreak].

Jorge Solano-López José Luís Zamorano Ana Pardo Sanz Ignacio J. Amat‐Santos Fernando Sarnago

Introduction and objectives Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The objective of this study was to describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during the COVID-19 pandemic.Methods This prospective, multicenter, cohort study included all consecutive patients with AMI who underwent coronary angiography in a 30-day period corresponding chronologically with the COVID-19 outbreak (March 15 to April 15, 2020). Clinical presentations and outcomes were compared between COVID-19 and non-COVID-19 patients. The effect of COVID-19 on mortality was assessed by propensity score matching and with a multivariate logistic regression model.Results In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% [P 140 (OR, 23.45; 95%CI, 2.52-62.51; P = .005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43; P = .02) were independent predictors of in-hospital death.Conclusions During this pandemic, a high GRACE score and COVID-19 were independent risk factors associated with higher in-hospital mortality.

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Percutaneous vs. surgical axillary access for transcatheter aortic valve implantation: the TAXI registry

Panminerva Medica (2022)

Arturo Giordano Andreas Schaefer Oliver D. Bhadra Lenard Conradi Dirk Westermann

BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an established management strategy for severe aortic valve stenosis. Percutaneous axillary approach for TAVI holds the promise of improving safety without jeopardizing effectiveness in comparison to surgical access. We aimed at appraising the comparative effectiveness of percutaneous vs. surgical axillary approaches for TAVI.METHODS: We performed an international retrospective observational study using de-identified details on baseline, procedural, and 1-month follow-up features. Valve Academic Research Consortium (VARC)-3 criteria were applied throughout. Outcomes of interest were clinical events up to 1 month of follow-up, compared with unadjusted and propensity score-adjusted analyses.RESULTS: A total of 432 patients were included, 189 (43.8%) receiving surgical access, and 243 (56.2%) undergoing percutaneous access. Primary hemostasis failure was more common in the percutaneous group (13.2% vs. 4.2%, P<0.001), leading to more common use of covered stent implantation (13.2% vs. 3.7%, P<0.001). Irrespectively, percutaneous access was associated with shorter hospital stay (-2.6 days [95% confidence interval: -5.0; -0.1], P=0.038), a lower risk of major adverse events (a composite of death, myocardial infarction, stroke, type 3 bleeding, and major access-site related complication; odds ratio=0.44 [0.21; 0.95], P=0.036), major access-site non-vascular complications (odds ratio=0.21 [0.06; 0.77], P=0.018), and brachial plexus impairment (odds ratio=0.16 [0.03; 0.76], P=0.021), and shorter hospital stay (-2.6 days [-5.0; -0.1], P=0.038).CONCLUSIONS: Percutaneous axillary access provides similar or better results than surgical access in patients undergoing TAVI with absolute or relative contraindications to femoral access.

Axillary artery

Stroke

10.23736/s0031-0808.22.04750-4

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Self-expandable transcatheter heart valves for aortic stenosis. Short-term outcome and matched hemodynamic performance

Revista Española de Cardiología (English Edition) (2020)

Silvio Vera Luis Nombela‐Franco Sandra Santos‐Martínez Raúl Moreno Victor Alfonso Jiménez Díaz

Cardiac skeleton

10.1016/j.rec.2020.09.014

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The Use of Events to Achieve Social Change: The Case of ILGA Portugal

Springer eBooks (2023)

Inês Santos Inês Veiga Pereira Carla Pereira Diana Moreira Sandra Santos‐Martínez

10.1007/978-3-031-27377-3_8

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New Challenging Scenarios in Transcatheter Aortic Valve Implantation: Valve-in-valve, Bicuspid and Native Aortic Regurgitation

European Cardiology Review (2021)

Sandra Santos‐Martínez Ignacio J. Amat‐Santos

Transcatheter aortic valve implantation (TAVI) is the most frequently performed structural technique in the field of interventional cardiology. Initially, this procedure was only used in patients with severe symptomatic aortic stenosis and prohibitive risk. Now, barely one decade after its introduction, TAVI indications extend to low- and intermediate-risk patients. Despite these advances, several challenging scenarios are still on the periphery of the evidence base for TAVI. These include valve-in-valve procedures, lower-risk patients with bicuspid aortic valve and the treatment of pure aortic regurgitation. Whereas the valve-in-valve indication has expanded rapidly, evidence for the use of TAVI compared with conventional surgery for bicuspid aortic valve is limited, including the best choice of device should TAVI be used. Evidence for TAVI in pure aortic regurgitation is still anecdotal because of suboptimal outcomes. Operators worldwide have described variations in the TAVI procedural technique to achieve commissural alignment and to minimise the rate of pacemaker use through cusp overlap implantation. In light of the potential clinical benefits, this may also be an area of further development. This review aims to discuss the current evidence available supporting the use of TAVI for these new indications.

Bicuspid valve

Aortic valve regurgitation

10.15420/ecr.2021.12

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Choice of CTO scores to predict procedural success in clinical practice. A comparison of 4 different CTO PCI scores in a comprehensive national registry including expert and learning CTO operators

PLoS ONE (2021)

Pablo Salinas Nieves Gonzalo Víctor H. Moreno Manuel Fuentes Sandra Santos‐Martínez

We aimed to compare the performance of the recent CASTLE score to J-CTO, CL and PROGRESS CTO scores in a comprehensive database of percutaneous coronary intervention of chronic total occlusion procedures.Scores were calculated using raw data from 1,342 chronic total occlusion procedures included in REBECO Registry that includes learning and expert operators. Calibration, discrimination and reclassification were evaluated and compared.Mean score values were: CASTLE 1.60±1.10, J-CTO 2.15±1.24, PROGRESS 1.68±0.94 and CL 2.52±1.52 points. The overall percutaneous coronary intervention success rate was 77.8%. Calibration was good for CASTLE and CL, but not for J-CTO or PROGRESS scores. Discrimination: the area under the curve (AUC) of CASTLE (0.633) was significantly higher than PROGRESS (0.557) and similar to J-CTO (0.628) and CL (0.652). Reclassification: CASTLE, as assessed by integrated discrimination improvement, was superior to PROGRESS (integrated discrimination improvement +0.036, p<0.001), similar to J-CTO and slightly inferior to CL score (- 0.011, p = 0.004). Regarding net reclassification improvement, CASTLE reclassified better than PROGRESS (overall continuous net reclassification improvement 0.379, p<0.001) in roughly 20% of cases.Procedural percutaneous coronary intervention difficulty is not consistently depicted by available chronic total occlusion scores and is influenced by the characteristics of each chronic total occlusion cohort. In our study population, including expert and learning operators, the CASTLE score had slightly better overall performance along with CL score. However, we found only intermediate performance in the c-statistic predicting chronic total occlusion success among all scores.

10.1371/journal.pone.0245898

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Percutaneous extracorporeal membrane oxygenation during the COVID-19 pandemic. A Spanish multicenter registry

REC interventional cardiology (English Edition) (2020)

Sandra Santos‐Martínez Javier Martín Moreiras M. Eugenia Vázquez-Álvarez Yhivian Peñasco Aitor Uribarri

Pandemic

2019-20 coronavirus outbreak

10.24875/recice.m20000169

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6053-346. DISFUNCIÓN VENTRICULAR IZQUIERDA SUBCLÍNICA MEDIDA POR STRAIN EN PACIENTES INGRESADOS CON INFECCIÓN COVID-19. SEGUIMIENTO ECOCARDIOGRÁFICO A 30 DÍAS

Revista Española de Cardiología (2024)

Marina del Río López Paula Guedes Ramallo Andrea Romero Valero Carla Benavent García A Garcia Suarez

10.1016/s0300-8932(25)01041-3

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