Kaho Tominaga-Teshima

Nippon Veterinary and Life Science University

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Reiko Todaka

Kitasato University

Hiroshi Aoki

Teikoku Seiyaku (Japan)

Tomokazu Tamura

Hokkaido University

Shigeyuki Nakamura

Ministry of Agriculture, Forestry and Fisheries

Yoshihiro Sakoda

Hokkaido University

Mai Fukuhara

The Graduate University for Advanced Studies, SOKENDAI

Tetsuya Mizutani

Tokyo University of Agriculture and Technology

Kentaro Tateishi

Tokyo University of Agriculture and Technology

Junsuke Shirai

Tokyo University of Agriculture and Technology

Tsubasa Kobayashi

Kogakuin University

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Tokyo University of Agriculture and Technology

Nippon Veterinary and Life Science University

Hokkaido University

Suzuki (Japan)

Jikei University School of Medicine

National Institute of Infectious Diseases

Ministry of Agriculture, Forestry and Fisheries

Kagoshima University

The University of Tokyo

Kitasato University

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Molecular, biological, and antigenic characterization of a Border disease virus isolated from a pig during classical swine fever surveillance in Japan

Journal of Veterinary Diagnostic Investigation (2014)

Makoto Nagai Hiroshi Aoki Yoshihiro Sakoda Takashi Kozasa Kaho Tominaga-Teshima

In the current study, molecular, biological, and antigenic analyses were performed to characterize Border disease virus (BDV) strain FNK2012-1 isolated from a pig in 2012 in Japan. The complete genome comprises 12,327 nucleotides (nt), including a large open reading frame of 11,685 nt. Phylogenetic analysis revealed that FNK2012-1 was clustered into BDV genotype 1 with ovine strains. FNK2012-1 grew in porcine, bovine, and ovine primary cells and cell lines, but grew better in bovine and ovine cells than in porcine cells. Specific pathogen-free pigs inoculated with FNK2012-1 did not show any clinical signs. Noninoculated contact control pigs also did not show clinical signs and did not seroconvert. The results suggest that FNK2012-1 may be of ruminant origin and is poorly adapted to pigs. Such observations can provide important insights into evidence for infection and transmission of BDV, which may be of ruminant origin, among pigs.

Domestic pig

Classical swine fever

10.1177/1040638714541837

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