C Stock-Damgé

Institut National de Recherche en Santé Publique

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Marc Aprahamian

Institut de Recherche contre les Cancers de l’Appareil Digestif

ÉL

Évelyne Lhoste

Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés

A. Pousse

Université de franche-comté

Aaron Dentinger

GE Global Research (United States)

Jacques Marescaux

Institut de Recherche contre les Cancers de l’Appareil Digestif

R Noriega

Hospital General San Juan de Dios

F. Raul

Institut de Recherche contre les Cancers de l’Appareil Digestif

J.F. Grenier

Alberta Hospital Edmonton

W. Humbert

Centre National de la Recherche Scientifique

Grenier Jf

Cooperative Institutions

Inserm

Centre National de la Recherche Scientifique

University of Bologna

Université de Strasbourg

Hôpital Civil, Strasbourg

Hôpital d'Hautepierre

Policlinico S.Orsola-Malpighi

Institut National de Recherche en Santé Publique

Institut de Recherche contre les Cancers de l’Appareil Digestif

University of Miami

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Effect of chronic bombesin on pancreatic size, composition and secretory function in the rat.

Gut (1987)

C Stock-Damgé Évelyne Lhoste Marc Aprahamian A. Pousse

Bombesin administered subcutaneously to rats, three times daily for four days, induces pancreatic growth at a dose of 10 micrograms/kg. Growth was characterised by an increased pancreatic weight and content in protein and RNA, accompanied by cellular hypertrophy. Chronic bombesin also enhanced the pancreatic content in chymotrypsin and to a lesser degree its contents in amylase and lipase. The volume of the secretion and the output of enzymes in response to CCK under an infusion of secretin, however, remained unchanged although the functional capacity of individual cells to secret amylase and lipase was reduced. It is concluded that chronic bombesin exerts a trophic action on the rat pancreas but decreases the sensitivity of each cell to hormonal stimulation.

Secretin

Pancreatic juice

10.1136/gut.28.suppl.1

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Citations (9)

Effect of dietary fiber supplementation on the secretory function of the exocrine pancreas in the dog

American Journal of Clinical Nutrition (1983)

C Stock-Damgé Patrick Bouchet Aaron Dentinger Marc Aprahamian Jf Grenier

Secretin

Pancreatic juice

Bicarbonate

Basal (medicine)

10.1093/ajcn/38.6.843

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Citations (23)

Effects of Wheat Bran on the Exocrine Pancreas and the Small Intestinal Mucosa in the Dog

Journal of Nutrition (1984)

C Stock-Damgé Marc Aprahamian Françis Raul W. Humbert Pierre Bouchet

Secretin

Maltase

Pancreatic juice

Sucrase

Disaccharidase

Intestinal mucosa

Basal (medicine)

Brush border

10.1093/jn/114.6.1076

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Citations (11)

Effect of Chronic Alcohol Administration on Liver Morphology and on Brush Border Membrane Enzymes after Jejunoileal Bypass Operation in Rat

Digestion (1982)

F. Raul R Noriega C Stock-Damgé M Doffoël J.F. Grenier

To determine whether jejunoileal bypass operation and alcohol administration exerted a synergistic effect on the activities of brush border membrane enzymes and on liver morphology, adult rats where submitted either to sham operation or to jejunoileal bypass operation. 2 weeks after operation the rats received a 15% solution of ethanol during a period of 4 weeks, controls received water. In the sham-operated rats, alcohol provoked stimulation of the disaccharidase activities in the proximal jejunum but had no effect on these activities in the ileum. Bypass operation alone induced a significant increase in sucrase activity in the functioning ileum but had no effect on the jejunal disaccharidase activities. Alcohol administered after bypass provoked a further increase in ileal brush border sucrase activity. The increase of the brush border enzyme specific activities in the excluded loop resulted from the important protein loss observed in this segment. Alcohol alone or bypass operation by itself had little effect on liver morphology. In contrast, when associated they induced extensive accumulation of fat droplets in the hepatocytes. Since alcohol is frequently associated with the diet in man, alcohol should be considered as an important contributing factor to intestinal enzyme adaptation and liver dysfunction after jejunoileal bypass operation.

Jejunoileal bypass

Disaccharidase

Brush border

Jejunum

Sucrase

10.1159/000198800

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Citations (3)

Influence of Repeated Administration of Bombesin on Rat Pancreatic Secretion

Pancreas (1987)

C Stock-Damgé Évelyne Lhoste M. Aprahamian Estíbaliz Loza

To study the effects of chronic bombesin on pancreatic growth and secretion, rats were injected subcutaneously, 3 times daily for 4 days with either saline or bombesin (10 micrograms/kg). Bombesin significantly increased the pancreatic weight and content in protein and RNA but not in DNA. The ratios of the three former parameters to DNA increased, suggesting cellular hypertrophy. The pancreatic content in enzymes was also elevated, especially for chymotrypsin and to a lesser degree for amylase. However, the volume of pancreatic secretion and the output of enzymes in response to CCK under a continuous infusion of secretin remained unchanged. The in vitro secretory response to caerulein and bombesin was reduced for amylase and lipase. It is concluded that chronic bombesin exerts a trophic action on the rat pancreas but decreases the sensitivity of each cell to hormonal stimulation.

Secretin

Pancreatic juice

10.1097/00006676-198711000-00006

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Citations (4)

[Pancreatic and intestinal adaptation following proximal or distal resection of the small intestine in the rat].

PubMed (1985)

Tibor Wittmann Évelyne Lhoste Marc Aprahamian C Stock-Damgé

The comparative effect of a 50% proximal or distal enterectomy on the exocrine pancreas and the remaining intestine has been studied in the rat one month after operation. Distal enterectomy induces (1) growth of the pancreas, characterized by a parallel increase in pancreatic weight, protein, DNA, RNA, amylase, lipase and chymotrypsin content, (2) preferential adaptation of the remaining ileum. Proximal enterectomy did not modify the pancreatic parameters studied but brings about an adaptation of the duodenum, the remaining jejunum and the ileum. It is concluded that pancreatic and intestinal adaptations differ after proximal and distal enterectomy.

Jejunum

Source

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Citations (2)

Gastrin Modulation of Pancreatic Growth

Scandinavian Journal of Gastroenterology (1985)

C Stock-Damgé Évelyne Lhoste Marc Aprahamian A. Pousse Inserm

Gastrin has been proposed as a trophic factor for the pancreas. Extensive small-bowel resection increased transiently plasma gastrin levels in the rat and produced pancreatic growth. This growth was characterized by an increased pancreatic weight, protein and DNA content, and the occurrence of mitotic figures in acinar cells. In order to determine if gastrin is implicated in pancreatic hyperplasia, we induced endogenous variations of gastrin 3 weeks before small-bowel resection or transection. Hypogastrinemia was produced by antrectomy and hypergastrinemia by vagotomy plus pyloroplasty. Pyloroplasty alone was without any effect. All gastric operations alone enhanced though not significantly the weight of the pancreas and its content in protein and DNA. When performed before intestinal resection, they did not modify the hyperplastic response of the pancreas to the resection. Our findings do not support the views that antral gastrin exerts a trophic action on the rat pancreas and that gastrin is implicated in postresectional hyperplasia of the gland.

Gastrointestinal hormone

10.3109/00365528509092215

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Citations (14)

Pancreatic Hyperplasia after Small Bowel Resection in the Rat: Dissociation from Endogenous Gastrin Levels

Digestion (1984)

C Stock-Damgé Marc Aprahamian Évelyne Lhoste A. Pousse W. Humbert

Extensive small bowel resection produces pancreatic hyperplasia and increases plasma gastrin levels in the rat. Because gastrin is known as a trophic factor for the exocrine pancreas, we studied the effect of endogenous variations of gastrin induced by different gastric operations on the rat pancreas in both resected and transected animals. Vagotomy increased plasma gastrin level while antrectomy decreased it; pyloroplasty was without any effect. These gastric operations enhanced slightly but not significantly the pancreatic weight, its protein and DNA content. A 90% jejunoileal resection alone increased markedly these parameters while mitotic figures appeared in acinar cells. Pyloroplasty, vagotomy and antrectomy did not modify the changes induced by intestinal resection itself except the level of protein. These findings suggest that hypergastrinemia produced by intestinal resection is not responsible for pancreatic hyperplasia.

Pyloroplasty

Gastrointestinal hormone

10.1159/000199037

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Citations (31)

Existe-t-il un facteur trophique d'origine intestinale responsable de l'adaptation pancréatique après résection étendue de l'intestin grêle chez le rat ? Etude préliminaire

annales de biologie animale biochimie biophysique (1984)

Évelyne Lhoste Marc Aprahamian J. F. LAUNAY C Stock-Damgé

10.1051/rnd:19840628

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Citations (1)

Small bowel bypass prevents the trophic action of cholecystokinin on the rat pancreas

International Journal of Pancreatology (1987)

C Stock-Damgé Marc Aprahamian Évelyne Lhoste Jacques Marescaux Eufrasio Loza

The effect of a chronic administration of cholecystokinin (CCK) on the rat pancreas has been studied in rats subjected to a 90% jejunoileal bypass or an intestinal transection (controls). Jejunoileal bypass, when compared to transection, did not modify the size of the pancreas but decreased its enzyme content, especially for amylase, and reduced the number of zymogen granules. These structural and biochemical changes were maintained when bypassed animals were treated three times daily and for six days with cholecystokinin (20 Ivy Dog Units (IDU)/kg). In contrast, CCK treatment in transected animals induced growth of the pancreas due to cellular hypertrophy and hyperplasia; pancreatic enzyme content, especially for chymotrypsin, and the population of zymogen granules in acinar cells were also enhanced. It is concluded that jejunoileal bypass prevents the trophic action of chronic CCK on the pancreas.

Zymogen

10.1007/bf02788403

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Citations (4)