Ute Möllmann

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

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i-10 index

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Co-Authors

Ralf Schmitz

University Hospital Münster

Mareike Möllers

University Hospital Münster

Marvin J. Miller

University of Notre Dame

Lothar Heinisch

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

Kerstin Hammer

University Hospital Münster

Walter Klockenbusch

University Hospital Münster

Hans‐Martin Dahse

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

M. Falkenberg

University Hospital Münster

Věra Klimešová

University of Hradec Králové

W Klockenbusch

University of Münster

Cooperative Institutions

Friedrich Schiller University Jena

Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

University Hospital Münster

University of Notre Dame

Naturstoff-Technik (Germany)

University of Münster

Charles University

Schiller International University

Leibniz Association

Klinik für Frauenheilkunde

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OP10.04: Assessment of cervical elastography strain pattern and its association with preterm birth

Ultrasound in Obstetrics and Gynecology (2017)

Ralf Schmitz Vera Oturina Kerstin Hammer Mareike Möllers Walter Klockenbusch

The aim of the study was to assess the cervical strain pattern by an ultrasound elastography cervix examination and to determine its association with preterm delivery. In this study, 30 cases resulting in preterm birth and 30 gestational age-matched controls were included. A vaginal ultrasound examination with cervical length and elastography measurement was performed. We calculated four strain ratios (SR1–SR4) of the regions of interest (ROIs) arranged in pairs in four different positions on the anterior cervical lip. The strain ratios were correlated to the outcome of spontaneous preterm delivery. The interobserver and intraobserver variability of the strain measurement was evaluated. We observed an association between the value of the strain ratio that was calculated from the ROIs placed side by side in the middle of the anterior lip (SR4), and preterm delivery (P < 0.001). The predictive values of cervical length and SR4 were comparable (AUC 0.7394; AUC 0.8322, respectively). The combination of cervical length and SR4 was superior in predicting preterm delivery compared to both parameters alone (AUC 0.8789). The interobserver and intraobserver variability of data acquisition and measurement was excellent. Our study assesses the cervical elastography strain pattern and shows a correlation to a spontaneous preterm birth.

Strain (injury)

10.1002/uog.17782

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Citations (0)

Selective growth promotion and growth inhibition of gram-negative and gram-positive bacteria by synthetic siderophore-beta-lactam conjugates.

BioMetals (1998)

Ute Möllmann Arun K. Ghosh E. Kurt Dolence J A Dolence Manuka Ghosh

Porin

Conjugate

10.1023/a:1009266705308

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Citations (39)

Imaging of fetal thymus in pregnant women with rheumatic diseases

Journal of Perinatal Medicine (2014)

Ann-Christin Warby Susanne Amler Annett M. Jacobi Kerstin Hammer Ute Möllmann

To determine whether certain rheumatic diseases will affect the fetal thymus diameter when compared to uncomplicated singleton pregnancies. Additionally, we created a reference chart for fetal thymus size in healthy singleton pregnancies from 19 to 37 weeks of gestation.Sonographic fetal thymus size was retrospectively evaluated in 190 healthy pregnant women, and 84 pregnancies of mothers suffering from systemic lupus erythematosus, antiphospholipid syndrome (APS), or Sjögren's syndrome between 19 and 37 weeks of gestation. These fetuses were matched one-to-one for gestational age with control fetuses. The thymic-thoracic ratio (TT-ratio) was defined as the quotient of the anteroposterior thymic and the intrathoracic mediastinal diameter.Rheumatic diseases often affect pregnancy outcome, especially in case of primary APS. The TT ratio of fetuses of mothers suffering from rheumatic disease was equal to controls (P=0.807).Ours is the first study to assess the correlation of fetal thymus size in high-risk pregnancies with rheumatic diseases in comparison to controls. Women with rheumatic diseases deal with pregnancy complications more frequently than controls. Our data suggest that maternal rheumatic diseases do not affect the fetal thymus size.

Rheumatic disease

10.1515/jpm-2013-0314

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Citations (16)

CCDC 103706: Experimental Crystal Structure Determination

The Cambridge Structural Database (2000)

R. Kreig Ralf Wyrwa Ute Möllmann Helmar Görls Bruno Schönecker

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc3gxct

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Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy

ACS Medicinal Chemistry Letters (2014)

Rohit Tiwari Ute Möllmann Sang‐Hyun Cho Scott G. Franzblau Patricia A. Miller

Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), is a global public health concern because of the emergence of various resistant strains. Benzothiazin-4-ones (BTZs), represented by BTZ043, are a promising new class of agents for the treatment of tuberculosis and have been shown to kill Mtb in vitro, ex vivo, and in mouse models of TB. Herein we report the design and syntheses of nitroaromatic sulfonamide, reverse-amide, and ester classes of anti-TB agents using a scaffold simplification strategy based on BTZ043. The presented work explores the effect of functional groups such as sulfonamides, reverse-amides, and esters that are attached to the nitroaromatic rings on their anti-TB activity. The in vitro activity of the compounds evaluated against the H37Rv strain of Mtb show that nitroaromatic sulfonamides and nitrobenzoic acid esters with two nitro substituents were most active and highlights the importance of the electronic character (electron deficient aromatic ring) of the nitroaromatic ring as a central theme in these types of nitroaromatic anti-TB agents.

10.1021/ml500039g

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Citations (35)

Identification of Antitubercular Benzothiazinone Compounds by Ligand-Based Design

Journal of Medicinal Chemistry (2012)

Tomislav Karoli Bernd Becker Johannes Zuegg Ute Möllmann Soumya Ramu

1,3-Benzothiazin-4-ones (BTZs) are a novel class of TB drug candidates with potent activity against M. tuberculosis. An in silico ligand-based model based on structure–activity data from 170 BTZ compounds was used to design a new series. Compounds were tested against a panel of mycobacterial strains and were profiled for cytotoxicity, stability, and antiproliferative effects. Several of the compounds showed improved activity against MDR-TB while retaining low toxicity with higher microsomal, metabolic, and plasma stability.

Identification

10.1021/jm3008882

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Citations (43)

Novel catecholate-type siderophore analogs based on a myo-inositol scaffold.

BioMetals (1998)

Matthias Schnabelrauch Daniel Ayuk Mbi Egbe Lothar Heinisch Rolf Reissbrodt Ute Möllmann

Polarity (international relations)

Derivative (finance)

10.1023/a:1009245309183

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Citations (5)

Inside Cover: In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation (Angew. Chem. Int. Ed. 8/2017)

Angewandte Chemie International Edition (2017)

Florian Kloß Viktor Krchňák Anna Krchňáková Sebastian Schieferdecker Julia Dreisbach

Nitrobenzothiazinones are highly potent antibiotics against Mycobacterium tuberculosis. While their killing mechanism involves the reduction of the nitro to a reactive nitroso group, F. Kloss and co-workers describe in their Communication on page 2187 ff. a previously overlooked in vivo bioreduction pathway. The metabolites are transient hydride Meisenheimer complexes that are readily reoxidized under atmospheric conditions and completely unprecedented among drug metabolites.

Mycobacterium avium complex

10.1002/anie.201700069

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Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Science (2009)

Vadim Makarov Giulia Manina Katarı́na Mikus̃ová Ute Möllmann O. B. Ryabova

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase as a major BTZ target. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. The most advanced compound, BTZ043, is a candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant TB.

Lipoarabinomannan

Arabinogalactan

10.1126/science.1171583

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Citations (695)

Fetal lung sequestration - diagnosis, prenatal treatment and postpartal procedure

Ultraschall in der Medizin - European Journal of Ultrasound (2013)

M. Falkenberg Mareike Möllers Ute Möllmann Karissa C. Hammer W Klockenbusch

Purpose: Fetal lung sequester is defined as a malformation of lung parenchym without any connection to the trachea and independent blood supply arising from the aorta. A hyperechogenic mass can be detected via ultrasound, which may include massive pleural effusions. Prenatal diagnosis and multidisciplinary treatment are essential to provide optimal care for each individual patient.

Prenatal ultrasound

Bronchopulmonary sequestration

10.1055/s-0033-1355013

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