Amit Goel

Research Field

Background: Cirrhosis, an advanced stage of liver diseases, induces Cirrhosis-Associated Immune Dysfunction Syndrome (CAIDS) characterized by both innate and adaptive immune dysfunction. Inflammation triggered by factors such as alcohol, viruses, toxins, and cholesterol induce metabolic reprogramming of both innate and adaptive immune cells. Our study specifically sought to investigate the compromised adaptive immune response in cirrhosis by focusing on assessing T-cell exhaustion and activation markers on helper and cytotoxic T cells. Method: A prospective observational study involving 19 liver cirrhosis patients and 36 healthy controls was conducted. Hepatic decompensation degree was assessed using various parameters including serum bilirubin, albumin, international normalized ratio, ascites and hepatic encephalopathy. T cell activation (CD38, CD44, CD69, HLADR), and exhaustion markers (CTLA-4, PD-1, TIM-3, LAG-3) were assessed on helper and cytotoxic T cells by flow cytometry. Result: Cirrhosis patients showed reduced T cells with no alteration in CD4:CD8 T cell ratio. Among activation markers, HLADR showed increased expression on CD8+ T cells (P=0.031). Regarding exhaustion markers LAG-3 and TIM-3 exhibited increased expression in cirrhotic patients compared to controls in both CD4 and CD8 T cells (P=0.004, P=0.016, P=0.001, P=0.004, respectively). Neither cirrhotic nor healthy controls showed CTLA expression. PD-1 did not differ significantly between the two groups. Co-expression of PD-1/TIM-3 on CD8+ T cells was notably higher in cirrhotic patients (P<0.002). Conclusion: The observation of impaired adaptive immunity with notable T cell exhaustion and activation in cirrhosis underscores the potential relevance of immunotherapy.

10.1177/10815589251320368

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TCT-750 Radial Artery Occlusion - Incidence, Predictors and Long term outcome after TRAnsradial Catheterization: Clinico-Doppler ultrasound based Study (RAIL-TRAC Study)

Journal of the American College of Cardiology (2018)

Santosh Kumar Sinha Puneet Aggarwal Mukesh Jitendra Jha Vikas Mishra Amit Goel

Doppler ultrasound

Cardiac catheterization

10.1016/j.jacc.2018.08.1975

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Troubleshooting during pacemaker implant in persistent left superior vena cava with absence of right superior vena cava (isolated persistent left superior vena cava)

Avicenna Journal of Medicine (2016)

Mahmadulla Razi Amit Madaan Amit Goel Santosh Kumar Sinha

Persistent left superior vena cava (PLSVC) with absence of right SVC (isolated PLSVC) is a rare congenital anomaly that occurs as a result of a degenerative condition in the left anterior cardinal vein. It is generally an incidental finding while performing invasive procedures such as antiarrhythmic device implantation. We report on a rare case of permanent pacemaker implantation in a patient with this anomaly from right subclavian route, albeit most of the earlier reported cases are from left subclavian approach. A wide spectrum of clinicians should be aware of this anomaly, its variations, and possible complications.

10.4103/2231-0770.179550

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Prevalence of hepatitis E virus viremia and antibodies among healthy blood donors in India

Indian Journal of Gastroenterology (2018)

Harshita Katiyar Amit Goel Atul Sonker Vishwajeet Yadav Sadul Sapun

Hepatitis E Virus

Viremia

Subclinical infection

Hepatitis E

10.1007/s12664-018-0880-7

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Citations (24)

Definitions, Etiologies, and Outcomes of Acute on Chronic Liver Failure: A Systematic Review and Meta-analysis

Clinical Gastroenterology and Hepatology (2024)

Arnav Aggarwal Sagnik Biswas Umang Arora Manas Vaishnav Abhishek Shenoy

Etiology

10.1016/j.cgh.2024.04.018

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A Rare Psoas Hernia: Endoscopic Diagnosis and Management

Surgical Laparoscopy Endoscopy & Percutaneous Techniques (2006)

Amit Goel Vandana Soni Rajesh Khullar Anil Sharma Manish Baijal

Of the various traumatic injuries associated with blunt abdominal trauma, traumatic hernias form a rare and small group. We present a case report of a hernia in the psoas muscle in a 26-year-old lady diagnosed during extraperitoneal repair for inguinal hernia. The hernia was managed laparoscopically by reduction of contents and mesh placement over the defect. This is the first such case reported in the literature till date.

Blunt trauma

10.1097/00129689-200604000-00013

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Sofosbuvir/Velpatasvir/Voxilaprevir for HCV Retreatment In Difficult To Treat Patients Who Failed With First-Line Direct Acting Antivirals: A Real-Life Data From India

Journal of Clinical and Experimental Hepatology (2023)

Harshita Katiyar Mrunal Kamat Ameet kumar Mandot Amit Goel Surender Singh

Sofosbuvir

Compassionate Use

10.1016/j.jceh.2023.07.252

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