Background: Vulvovaginal candidiasis is one of the most common infections in gynecologic filed, and non–albicans Candida species are emerging causative microorganisms. This species shows resistance to routine treatments. One of the suggested treatments is administration of vaginal suppositories of boric acid. The aim of the present study was to compare boric acid with clotrimazole in the treatment of recurrent or resistant vulvovaginitis. Methods: In a double-blind, randomized clinical trial, 90 nonpregnant women were enrolled. The patients were divided into two groups to receive; boric acid (300 mg twice a day for 2 weeks) or clotrimazole (100 mg once a day for 2 weeks) intravaginally. Treatment responses were monitored by laboratory and clinical data. Results: Treatment responses were significantly different in laboratory results for boric acid and clotrimazole groups (86.7% v 60%, P= 0.004). Clinical responses (improved signs and symptoms) showed no significant differences (8.2. v 6.5, P= 0.02). Drug side effects were not different in boric acid and clotrimazole groups (13.3% v 11.1%, P= 0.75).
To evaluate the spectrum of probable vascular complications due to short-term oral contraceptives OC consumption.In this cohort study, selected Iranian female pilgrims from Razavi-Khorasan, Iran province <50 years old, attending Hajj in 2005 were evaluated. We reviewed their physical examinations, vascular risk factors and OC consumption before Hajj. Pilgrims were followed-up in terms of developing possible vascular complications during Hajj and the following year.This study included 896 individuals and completed follow-up was performed for 642. The results showed that 782 (87.3%) of pilgrims used OC. One person developed cerebral vein thrombosis, one myocardial infarction, and one deep vein thrombosis. Eighteen patients (2.8%) experienced transient hypertension. Ten patients (1.5%) had migraine exacerbations. The relationship between developed definite vascular complications and OC consumption was not statistically significant in this study p=0.365.Although vascular complications of long-term OC consumption have been analyzed and proved in several studies, few studies have determined short-term OC consumption effects on the vascular system. It seems that even short-term usage of OC may result in vascular complications, thus further studies with more samples is recommended to determine its safety and complications.