Anna Nowakowska-Płaza

National Institute of Geriatrics, Rheumatology and Rehabilitation

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Iwona Sudoł‐Szopińska

National Institute of Geriatrics, Rheumatology and Rehabilitation

Piotr Głuszko

National Institute of Geriatrics, Rheumatology and Rehabilitation

Jakub Wroński

National Institute of Geriatrics, Rheumatology and Rehabilitation

Mateusz Płaza

National Institute of Geriatrics, Rheumatology and Rehabilitation

Katarzyna Romanowska‐Próchnicka

National Institute of Geriatrics, Rheumatology and Rehabilitation

Lucyna Papierska

Postgraduate School of Molecular Medicine

Małgorzata Wisłowska

Central Clinical Hospital

Karolina M. Nowak

Grochowski Hospital

Agnieszka Zielińska

Nicolaus Copernicus University

J Falkowski

National Institute of Geriatrics, Rheumatology and Rehabilitation

Cooperative Institutions

National Institute of Geriatrics, Rheumatology and Rehabilitation

Medical University of Warsaw

Center for Rheumatology

Postgraduate School of Molecular Medicine

Institute of Rheumatology

The Maria Sklodowska-Curie National Research Institute of Oncology

Grochowski Hospital

Jagiellonian University

Pomeranian Medical University

Fundacion Instituto de Reumatologia Fernando Chalem

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Lymphocytic Interstitial Pneumoniae as an extremely rare manifestation of systemic lupus erythematosus

Polskie Archiwum Medycyny Wewnętrznej (2021)

Magdalena Roszkowska Anna Nowakowska-Płaza Jakub Wroński Mateusz Płaza Agnieszka Zielińska

Systemic lupus

10.20452/pamw.16115

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Citations (2)

Cranial and extracranial manifestations of giant cell arteritis: a single-center observational study

Rheumatology International (2024)

Emilia Kudraszew Anna Nowakowska-Płaza Jakub Wroński Mateusz Płaza Małgorzata Wisłowska

Giant cell arteritis (GCA) presents two major phenotypes - cranial (cGCA) and extracranial (exGCA). exGCA may be overlooked. The study aimed to compare the clinical characteristics between cGCA and exGCA.

Demographics

Medical record

Single Center

10.1007/s00296-024-05608-2

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Artropatia Charcota w obrazie ultrasonograficznym – opis przypadku

Journal of Ultrasonography (2016)

Mateusz Płaza Anna Nowakowska-Płaza Marta Walentowska-Janowicz Marek Chojnowski Iwona Sudoł‐Szopińska

This article presents a patient with a long history of type 1 diabetes mellitus complicated with neuropathy and Charcot disease.The most common cause of neuropathic osteoarthropathy, called Charcot osteoarthropathy, is poorly controlled diabetes.The clinical picture is characterized by considerable edema, redness and increased skin temperature with relatively slight pain due to injury to nerve fibers responsible for pain sensation.The differential diagnosis should include bacterial or autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury.The contribution of a local inflammatory reaction and abnormal bone turnover with excessive osteoclast activity might play a role in the etiopathogenesis of this disease.As a result, osseous and articular destruction progresses rapidly leading to irreversible deformity of the foot.Avoiding weight-bearing and resting the foot in a specially selected plaster cast is the most important part of treatment.Patients with the aforementioned complaints are referred to radiologists for imaging examinations.An ultrasonographer should pay attention to changes typical of Charcot arthropathy, such as: inflammatory and destructive changes in joints of the foot, uneven contour of bones with thickening and periosteal hyperemia as well as soft tissue swelling. StreszczeniePrzedstawiamy opis przypadku pacjenta chorującego od wielu lat na cukrzycę typu 1 powikłaną neuropatią i artropatią Charcota.Najczęstszą przyczyną osteoartropatii neurogennej, zwanej osteoartropatią Charcota, jest źle wyrównana cukrzyca.W

Spinal osteoarthropathy

Bone pain

Limp

10.15557/jou.2016.0022

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Impact of glucocorticoid receptor gene polymorphisms on occurrence of steroid-induced adverse events

Endocrine Abstracts (2019)

Karolina M. Nowak Marta Sobalska‐Kwapis Monika Rdzanek Katarzyna Romanowska‐Próchnicka Anna Nowakowska-Płaza

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

10.1530/endoabs.67.o17

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Prevention and treatment of steroid-induced osteoporosis – recommendations vs clinical practice

Postępy Nauk Medycznych (2017)

Karolina M. Nowak Agnieszka Łebek-Szatańska Anna Nowakowska-Płaza Katarzyna Romanowska‐Próchnicka Agnieszka Zielińska

Clinical Practice

10.25121/pnm.2017.30.12.645

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Oral glucose tolerance test is recommended for screening for new-onset glucose metabolism impairment during chronic low-dose glucocorticoid therapy

Endocrine Abstracts (2019)

Karolina Nowak Monika Rdzanek Agnieszka Łebek-Szatańska Anna Nowakowska-Płaza Agnieszka Zielińska

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Carbohydrate Metabolism

Glucose tolerance test

10.1530/endoabs.63.p579

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Antibodies to N-homocysteinylated albumin and haemoglobin in patients with rheumatoid arthritis: a potential new marker of disease severity

Scandinavian Journal of Rheumatology (2013)

Anna Nowakowska-Płaza Daniel P. Potaczek Piotr Głuszko Anetta Undas

Objectives: To investigate whether anti-Nε-homocysteinylated albumin (anti-N-Hcy-Alb) and haemoglobin (anti-N-Hcy-Hb) antibodies occur in rheumatoid arthritis (RA) and whether they are associated with RA activity and/or severity.Method: Plasma total homocysteine (tHcy) and serum anti-N-Hcy-Alb and -Hb antibodies levels were determined in 76 RA patients (12 men and 64 women, median age 56 years) and 80 age- and sex-matched controls.Results: RA patients compared to healthy controls demonstrated elevated tHcy [median (IQR), 13.20 (3.80) vs. 9.45 (3.25) μmol/L; p < 0.000001] and anti-N-Hcy-Alb and -Hb antibodies [absorbance at 490 nm, median (IQR), 0.546 (0.085) vs. 0.452 (0.056) and 0.649 (0.106) vs. 0.532 (0.057), respectively; all p < 0.000001]. In RA patients, RA radiological class was a strong independent predictor of tHcy [β (SE), 0.59 (0.11); p = 0.000001] and anti-N-Hcy-Alb [0.36 (0.12); p = 0.003] and -Hb [0.49 (0.11); p = 0.00007] antibodies. The number of swollen joints, but not C-reactive protein (CRP), interleukin 6 (IL-6), positive rheumatoid factor (RF), or anti-cyclic citrullinated peptide (anti-CCP) antibodies, showed independent effects on anti-N-Hcy-Alb [β (SE), 0.36 (0.11); p = 0.001] and -Hb [0.25 (0.11); p = 0.02] antibodies. Anti-N-Hcy-Hb antibodies, but not those against N-Hcy-Alb, were positively correlated with RA functional class and RA duration. No effect of any medications on tHcy or anti-N-Hcy-protein antibodies was observed.Conclusions: This study is the first to show that RA is characterized by enhanced autoimmune response to Nε-homocysteinylated proteins detectable in circulating blood, which is related to some clinical measures of RA severity.

Rheumatoid factor

10.3109/03009742.2013.811537

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Imaging methods in monitoring gout – a pictorial essay

Journal of Ultrasonography (2024)

Maria Sotniczuk Anna Nowakowska-Płaza Marek Leszkiewicz Iwona Sudoł‐Szopińska

We present a pictorial essay based on the case of a 52-year-old man suffering from chronic gout, who was followed up for seven years. During this period of time, radiographs, ultrasonography, and dualenergy computed tomography were performed several times, revealing severe progression of gout. This was most likely due to the lack of patient compliance. Inflammatory and destructive lesions were observed in the wrists, in the metacarpophalangeal and proximal interphalangeal joints. Ultrasonography showed tenosynovitis, synovitis with small calcifications in the synovial membrane. Radiographs obtained in later stages showed tophi and bone erosions. Dual-energy computed tomography showed deposits of monosodium urate crystals in different locations, which increased in volume over time. This modality can be used to confirm a clinical diagnosis of gout, especially in early stages of the disease, and to follow up the treatment.

Interphalangeal Joint

Tenosynovitis

10.15557/jou.2024.0022

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Dual energy computed tomography – a novel imaging method on the two examples of a rare course of gout

Polskie Archiwum Medycyny Wewnętrznej (2019)

Agnieszka Zielińska Anna Nowakowska-Płaza J Falkowski Małgorzata Stasiek Iwona Sudoł‐Szopińska

Course (navigation)

10.20452/pamw.4427

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The Clinical Utility of Dual-Energy Computed Tomography in the Diagnosis of Gout—A Cross-Sectional Study

Journal of Clinical Medicine (2022)

Maria Sotniczuk Anna Nowakowska-Płaza Jakub Wroński Małgorzata Wisłowska Iwona Sudoł‐Szopińska

Dual-energy computed tomography (DECT) is an imaging technique that detects monosodium urate (MSU) deposits. This study aimed to assess the clinical utility of DECT in the diagnosis of gout. A total of 120 patients with clinical suspicion of gout who underwent DECT were retrospectively enrolled. The sensitivity and specificity of DECT alone, American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) classification criteria without DECT, and ACR/EULAR criteria with DECT were assessed. Additionally, an analysis of gout risk factors was performed. When artifacts were excluded, any MSU volume provided the best diagnostic value of DECT (AUC = 0.872, 95% CI 0.806−0.938). DECT alone had a sensitivity of 90.4% and specificity of 74.5%. Although ACR/EULAR criteria without DECT provided better diagnostic accuracy than DECT alone (AUC = 0.926, 95% CI 0.878−0.974), the best value was obtained when combing both (AUC = 0.957, 95% CI 0.924−0.991), with 100% sensitivity and 76.6% specificity. In univariate analysis, risk factors for gout were male sex, presence of tophi, presence of MSU deposits on DECT, increased uric acid in serum (each p < 0.001), and decreased glomerular filtration rate (GFR) (p = 0.029). After logistic regression, only increased serum uric acid (p = 0.034) and decreased GFR (p = 0.018) remained independent risk factors for gout. Our results suggest that DECT significantly increases the sensitivity of the ACR/EULAR criteria in the diagnosis of gout.

Univariate analysis

10.3390/jcm11175249

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Citations (4)