Toplica Bojić

University of Nis

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Aleksandar Karanikolić

University of Nis

Miodrag Djordjević

University of Nis

Lidija Djordjević

University of Nis

Ivan Pešić

Institute of Chemistry, Technology and Metallurgy

N. Djordjević

University of Nis

Miomir Pešić

University of Nis

Milan Radojković

University of Nis

Mirjana Marinković

University of Nis

MĐ

Mihajlo Đorđević

University of Belgrade

Vesna Karanikolić

University of Nis

Cooperative Institutions

University of Nis

Klinički centar Niš

University of Belgrade

Deleted Institution

Univerzitetski Klinički Centar Srbije

Center for Health, Exercise and Sport Sciences

Institut za Reumatologiju

Centar za Promociju Nauke

Zdravstveni centar

University of Belgrade – Faculty of Medicine

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The role of EZH2 expression in predicting axillary lymph node metastasis in invasive ductal carcinoma of the breast

European Journal of Surgical Oncology (2024)

J. Svetlana M. Vucic Aleksandar Karanikolić L. Djordjević Toplica Bojić

Breast carcinoma

10.1016/j.ejso.2024.108912

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Uticaj hirurške traume na koncentraciju paratiroidnog hormona i kalcijuma u pacijenata podvrgnutih totalnoj tiroidektomiji kod benignih oboljenja štitaste žlezde

Универзитет у Нишу (2016)

Toplica Bojić

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Total thyroidectomy as a method of choice in the treatment of Graves’ disease - analysis of 1432 patients

BMC Surgery (2015)

Toplica Bojić Ivan Paunović Aleksandar Diklić Vladan Živaljević Goran Zorić

Graves' disease represents an autoimmune disease of the thyroid gland where surgery has an important role in its treatment. The aim of our paper was to analyze the results of surgical treatment, the frequency of microcarcinoma and carcinoma, as well as to compare surgical complications in relation to the various types of operations performed for Graves' disease.We analysed 1432 patients (221 male and 1211 female) who underwent surgery for Graves' disease at the Centre for Endocrine Surgery in Belgrade during 15 years (1996-2010). Average age was 34.8 years. Frequency of surgical complications within the groups was analyzed with nonparametric Fisher's test.Total thyroidectomy (TT) was performed in 974 (68%) patients, and Dunhill operation (D) in 221 (15.4). Carcinoma of thyroid gland was found in 146 patients (10.2%), of which 129 (9%) were a microcarcinoma. Complication rates were higher in the TT group, where there were 31 (3.2%) patients with permanent hypoparathyroidism, 9 (0.9%) patients with unilateral recurrent nerve paralysis and 10 (1.0%) patients with postoperative bleeding. Combined complications, such as permanent hypoparathyroidism with bleeding were more common in the D group where there were 2 patients (0,9%), while unilateral recurrent nerve paralysis with bleeding was more common in the TT group where there were 3 cases (0,3%).Frequency of complications were not significantly statistically different in relation to the type of surgical procedure. Total thyroidectomy represents a safe and efficient method for treating patients with Graves' disease, and it is not followed by a greater frequency of complications in relation to less extensive procedures.

Hypoparathyroidism

10.1186/s12893-015-0023-3

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TUMORS OF PARATHYROID GLANDS

Acta Medica Medianae (2019)

Lidija Djordjević Toplica Bojić Miodrag Djordjević Mirjana Marković Marinković

Parathyroid glands are small endocrine glands found in the neck which secrete parathyroid hormone or parathormone (PTH) which has a combined role together with calcitonin and vitamin D in regulating levels of calcium and phosphate concentrations in humans.The most common disease of parathyroid glands is increased and uncontrolled secretion of PTH which is defined as primary hyperthyroidism, if it is offset as a result of intensified function of one or more parathyroid glands, or as secondary hyperparathyroidism which is mostly caused by chronic kidney insufficiency or by vitamin D deficiency.Carcinoma of parathyroid glands is a rare disease and one of the rarest malignant endocrine tumors.Frequency of carcinoma in patients with primary hyperparathyroidism is less than 1%.Best treatment for patients with this primary lesion is intraoperative recognition of the tumor by surgeons, adequate resections with removal of primary lesion, and histopathological verification.

10.5633/amm.2019.0315

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Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades

Vojnosanitetski pregled (2012)

Toplica Bojić N. Djordjević Aleksandar Karanikolić Sladjana Filipovic Miroslav Granić

There are a lot of studies aiding to the opinion that the involvement degree of axilla lymph nodes grows depending on increase of breast tumor size, and its histological and nuclear grades. The aim of this study was to assess the risk of axillary lymph nodes involvement, as well as the relation between the tumor size, histological and nuclear grades in a group of female patients who underwent breast cancer surgery, including levels 1-3 axillary dissection.Investigationcovered 900 patients operated on during 2005-2008 who underwent modified radical mastectomy including axillar dissection. We assessed a number of involved lymph nodes, depending on tumor macroscopic size (T), histological grade (HG) and nuclear grade (NG).A total number of examined lymph nodes was 9977. The incidence of involved lymph nodes was from 18.6% with T1 tumor size up to 60.2% with T4 tumor size. Concerning histological grade, the number of involved lymph nodes ranged from 14.2% (HGI) to 45.1% (HGIII); while in terms of nuclear grade, the number of involved lymph nodes ranged from 17.4% (NGI) to 54.5% (NGIV). By using chi2-test for trend and odds ratio (OR), the results showed that the axillary lymph nodes involvement degree was increased with the increase of the tumor size and its histological and nuclear grades. The risk of axillary lymphatic nodes involvement was 1.43 times higher in the group of T2 tumors size compared to the smaller tumors T1 size, and even up to 6.62 times higher in case of T4 tumor size. It was also increasied from 1.79 times for HGII to even 4.98 times for HGIII, and from 1.44 times for NGII to 5.71 times for NGIV.In breast cancer patients, there is a strong correlation between tumor size, its histological and nuclear grades and the risk of axillary lymph nodes involvement.

Axillary lymph nodes

Breast tumor

10.2298/vsp1205414b

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Characteristics and outcomes of patients with multifocal/multicentric and unifocal breast cancer.

PubMed (2017)

Lidija Djordjevic-Jovanovic Aleksandar Karanikolić Toplica Bojić Ivan Pešić Miodrag Djordjević

The clinical behavior and outcome of multifocal (MF) and multicentric (MC) breast tumors are not well characterized. The purpose of this study was to compare the prognosis of MF/MC tumors with unifocal (UF)tumors and its correlation with other pathological characteristics and patient outcomes.Eighty-three patients with MC/MF breast cancer and 501 with UF breast cancer treated at the Surgical Clinic Nis were studied. We compared MC/MF and UF breast cancer patients with respect to demographics, tumor characteristics- adjuvant systemic therapy, local recurrence-free survival (LRFS) and overall survival (OS).There was no significant statistical difference between the two groups with respect to mean age at diagnosis, tumor grade, nodal status, estrogen receptor status, lymphovascular invasion (LVI) and adjuvant systemic therapy. The MC/MF group had more patients with modified radical mastectomy and the UF group had more patients with breast-conserving surgery. Cox multivariate regression analysis showed that the regional lymph node metastases and LVI were the most important predictors of 5-year OS rate. During this period, locoregional recurrence was registered in 29 (5.78%) patients in the UF group and in 5 (6.02%) patients in the MF/MC group (p=0.48). No statistically significant differences in the 5-year LRFS and OS between the two groups were noticed.The prognostic value of MF/MC disease is still not well known, although some studies have suggested that it is associated with a worse prognosis. This study showed no statistically significant difference in the 5-year LRFS and OS between UF and MF/MC groups.

Lymphovascular invasion

Adjuvant Therapy

Modified Radical Mastectomy

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Acute Suppurative Thyroiditis with Thyroid Abscess and Bilateral Pneumonia: A Case Report.

PubMed (2018)

Aleksandar Karanikolić Miodrag Djordjević N. Djordjević Ivan Pešić Lidija Djordjević

Acute suppurative thyroiditis (AST) leading to thyroid abscess is a rare clinical entity. The aim of this article is to demonstrate a case of severe bilateral pneumonia which originated from a thyroid abscess. The authors report the case of a 57-year-old woman with severe bilateral pneumonia of thyroid origin. The patient had a painful throat and dysphagia for 2 or 3 days. She also had a history of mild fever and hard breathing with a discreet cough 7 days prior to hospital admission. In the past few months, the patient had frequent pneumonias. The patient was treated with a culture-appropriate antibiotic and total thyroidectomy. Primary recommendations for treatment of complicated infections of thyroid origin consider a multidisciplinary approach. Recurrent pneumonia in patients with thyroid nodules may be the result of thyroid inflammation, and, in such patients, neck ultrasound should be conducted as part of the diagnostic workup.

Subacute thyroiditis

Aspiration Pneumonia

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INTERNAL HERNIA ASSOCIATED WITH MECKEL’S DIVERTICULUM IN GERIATRIC PATIENT

Acta Medica Medianae (2020)

Aleksandar Karanikolić Miodrag Djordjević Ivan Pešić Lidija Djordjević Nebojša Ignjatović

This report describes an unusual geriatric case of acute small bowel obstruction (SBO) due to Meckel diverticulum (MD).We present a 65 year old male with 90 cm portion of necrotic ileum.Another bowel segment portion with a strong giant MD adherence to the mesentery created a bridge.The mentioned bowel loops went through it, giving rise to an internal hernia.We want to highlight that internal hernias are not easy to diagnose clinically and abdominal CT images are strongly recommended when suspecting any case of internal hernia in geriatric population.

Internal hernia

10.5633/amm.2020.0114

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THE ROLE OF MULTISLICE COMPUTED TOMOGRAPHY IN THE EMERGENCY DIAGNOSIS OF THE TRACHEOBRONCHIAL INJURY AFTER ENDOTRACHEAL INTUBATION - CASE REPORT

Acta Medica Medianae (2015)

Aleksandar Karanikolić Zoran Damnjanović Vesna Karanikolić Ivan Pešić Biljana Stošić

Tracheobronchial injury (TBI) is a rare complication occurring after endotracheal intubation. Treatment can be conservative for small lesions and when the patient’s condition is stable, or surgical for bigger lesions and when pneumomediastinum and/or subcutaneous emphysema threaten the patient’s life. Total thyroidectomy was performed in a 60-year-old woman with multinodular goiter. Ten hours after surgery, subcutaneous emphysema of the face and neck developed. A cervical and thoracic multislice computed tomography (MSCT) confirmed subcutaneous emphysema, pneumomediastinum, and posterior wall tracheal rupture 2cm in size. The patient was treated conservatively. The MSCT imaging can be a useful method for diagnosing the location and form of tracheal injury in hemodynamically stable patients. Acta Medica Medianae 2015;54(1): 53-55.

Pneumomediastinum

Mediastinal Emphysema

Multislice

Endotracheal intubation

10.5633/amm.2015.0108

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385 Antibiotic Prophylaxis as a Preventative Wound Infection After Breast Surgery

European Journal of Cancer (2012)

N. Djordjević D. Budjevac L. Djordjević Aleksandar Karanikolić Toplica Bojić

Wound infection

10.1016/s0959-8049(12)70451-3

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