A.P.N. Barrére

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

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Silvia Maria Fraga Piovacari

Hospital Israelita Albert Einstein

Andréa Z Pereira

Hospital Israelita Albert Einstein

Nelson Hamerschlak

Hospital Israelita Albert Einstein

F. Lúcio

Hospital Israelita Albert Einstein

Diogo Oliveira Toledo

Hospital Israelita Albert Einstein

Juliana Moura Nabarrete

Hospital Israelita Albert Einstein

M Tanaka

Hospital Israelita Albert Einstein

Rene Claúdio Gansl

Hospital Israelita Albert Einstein

Juliana Bernardo Silva

Hospital Israelita Albert Einstein

Pedro Luiz Serrano Usón

Mayo Clinic in Arizona

Cooperative Institutions

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Hospital Israelita Albert Einstein

Universidade Federal de São Paulo

Hospital Universitário da Universidade de São Paulo

Hospital São Paulo

Universidade Brasil

Universidade Federal de Minas Gerais

Fundação de Apoio à Universidade Federal de São Paulo

Instituto do Coração

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MON-PP140: Hematopoietic Sten Cell Transplantation in the Elderly: Nutritional and Geriatric Assessment

Clinical Nutrition (2015)

Andréa Z Pereira Silvia Maria Fraga Piovacari Juliana Moura Nabarrete J.B. Silva Masanori Tanaka

Transplantation

10.1016/s0261-5614(15)30572-0

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Identification of Sarcopenia Risk in Oncology Outpatients using the SARC-F Method

Journal of Nutritional Health & Food Science (2018)

Diogo Oliveira Toledo A.P.N. Barrére Giovanna Guimarães Lopes Thaisa de Assis Silvia Maria Fraga Piovacari

Introduction: Sarcopenia is a common syndrome of highly catabolic diseases like cancer.Maintaining adequate body composition is fundamental for oncology patients' best prognosis.Existing tools to help in early identification of sarcopenia are limited and impractical in outpatient care.The SARC-F questionnaire, validated by Malmstrom et al, in order to screen the risk of sarcopenia can help on the early diagnosis and intervention.The objective of this study was to evaluate the sarcopenia risk in oncology outpatients by SARC-F tool, and to analyze its relationship with the Body Mass Index (BMI) and treatment toxicity.Method: A prospective study was carried out to 52 elderly oncology outpatients of a tertiary hospital clinic in São Paulo, Brazil.The patients' risk of sarcopenia was assessed by SARC-F questionnaire, through direct interview, at the time of radiotherapy or chemotherapy.The demographic data collected were sex, age, diagnosis, weight, presence of toxicity and BMI, (classified according to SABE PAHO, 2003).Toxicity classification was performed according to the Common Toxicity Criteria of the National Cancer Institute.Results: In the study, most patients were males (n=32, 61.53%), mean age was 72 years-old (± 8.4), weight showed mean of 72.9 kg (± 12.9) and BMI of 25, 65 kg/m² (±3, 85), classifying as eutrophic 55.7% (n=29), 19.2% underweight (n=10) and 25% overweight (n=13).Of the patients, 34 were undergoing to chemotherapy (65.38%) and 18 to radiotherapy (34.19%).The most frequent neoplasms were: prostate (n=8, 15, 38%), breast (n = 7, 13, 46%), lung (n=7, 13, 46% 62%) and others (n=25; 48.08%).Toxicity was presented in 55.76% of patients (n=29), being the most common inappetence (n=9; 31.03%);nausea (n=5; 17.24%) and diarrhea (n=5; 17.24%).Among the patients who presented a risk for sarcopenia (n=6; 11.53%), according to SARC-F, the majority were female (n=4; 66.6%) aged 80 to 90 years-old (n=3; 50.0%).Of patients at sarcopenia risk, 33.3% were underweight, 50.0%were eutrophic and 16.6% were overweight according to the BMI classification.Regarding toxicity, 66.6% (n=4) of the sarcopenia risk patients presented toxicity, 50.0% with inappetence (n=2) and 50.0% with nausea or diarrhea (n=2). Conclusion:There was a risk of sarcopenia in 11.53% of the patients (n=6), but it was not related to BMI.As for toxicity, the tool revealed a positive relation regarding sensitivity but without statistical relevance.SARC-F is a quick and simple screening method for sarcopenia, which can be applied by any healthcare professional.However, further studies are needed for application in clinical oncology area.

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10.15226/jnhfs.2018.001139

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Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Frontiers in Nutrition (2024)

Gabriela Salim de Castro Leonardo R. Gama Alexandre F. Ramos Guilherme Henrique Gatti da Silva Alexandre Abílio de Souza Teixeira

Introduction Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both the persistent and post-acute disease newly acquired symptoms are not yet fully described. Given the lack of robust knowledge regarding the mechanisms of PCC we have examined the impact of inflammation in PCC, by evaluating serum cytokine profile and its potential involvement in inducing the different symptoms reported. Methods In this cross-sectional study, we recruited 227 participants who were hospitalised with acute COVID-19 in 2020 and came back for a follow-up assessment 6–12 months after hospital discharge. The participants were enrolled in two symptomatic groups: Self-Reported Symptoms group (SR, n = 96), who did not present major organ lesions, yet reported several debilitating symptoms such as fatigue, muscle weakness, and persistent loss of sense of smell and taste; and the Self-Reported Symptoms and decreased Pulmonary Function group (SRPF, n = 54), composed by individuals with the same symptoms described by SR, plus diagnosed pulmonary lesions. A Control group ( n = 77), with participants with minor complaints following acute COVID-19, was also included in the study. Serum cytokine levels, symptom questionnaires, physical performance tests and general clinical data were obtained in the follow-up assessment. Results SRPF presented lower IL-4 concentration compared with Control ( q = 0.0018) and with SR ( q = 0.030), and lower IFN-α2 serum content compared with Control ( q = 0.007). In addition, SRPF presented higher MIP-1β serum concentration compared with SR ( q = 0.029). SR presented lower CCL11 ( q = 0.012 and q = 0.001, respectively) and MCP-1 levels ( q = 0.052 for both) compared with Control and SRPF. SRPF presented lower G-CSF compared to Control ( q = 0.014). Female participants in SR showed lower handgrip strength in relation to SRPF ( q = 0.0082). Male participants in SR and SRPF needed more time to complete the timed up-and-go test, as compared with men in the Control group ( q = 0.0302 and q = 0.0078, respectively). Our results indicate that different PCC symptom profiles are accompanied by distinct inflammatory markers in the circulation. Of particular concern are the lower muscle function findings, with likely long-lasting consequences for health and quality of life, found for both PCC phenotypes.

10.3389/fnut.2024.1295026

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Impacto da composição corporal na sobrevida e na toxicidade do tratamento no câncer de pâncreas: estudo transversal

A.P.N. Barrére Silvia Maria Fraga Piovacari Pedro Luiz Serrano Usón Rene Claúdio Gansl Andréa Z Pereira

Transversal (combinatorics)

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Current technologies in body composition assessment: advantages and disadvantages

Nutrition (2018)

Guilherme Duprat Ceniccola Melina Gouveia Castro Silvia Maria Fraga Piovacari L.M. Horie Fabiano Girade Corrêa