Franck Artzner

Institut de Physique de Rennes

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Co-Authors

Cristelle Mériadec

Institut de Physique de Rennes

Maı̈té Paternostre

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Bruno Bêche

Université de Rennes

ÉG

Étienne Gaviot

Le Mans Université

Anne Renault

Centre Hospitalier Régional Universitaire de Brest

ÉP

Émilie Pouget

Chimie et Biologie des Membranes et des Nanoobjects

Christophe Tarabout

Max Planck Institute of Colloids and Interfaces

Daphné Duval

UK Health Security Agency

Véronique Vié

Institut de Physique de Rennes

Céline Valéry

RMIT University

Cooperative Institutions

Centre National de la Recherche Scientifique

352

Université de Rennes

143

Inserm

Institut de Physique de Rennes

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Institut des Sciences Chimiques de Rennes

Université Paris-Saclay

Université Paris-Sud

Université Paris Cité

CEA Paris-Saclay

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Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma

International Journal of Pharmaceutics X (2022)

H. Alnemeh-Al Ali Audrey Griveau Franck Artzner Aurélien Dupont Nolwenn Lautram

NFL-TBS.40-63 peptide is a recently discovered peptide derived from the light neurofilament chain (NFL). In this study, we demonstrated that the Biotinylated-NFL-peptide (BIOT-NFL) can spontaneously self-assemble into well-organized nanofibers (approximately 5 nm width and several micrometers in length) in several solutions, whereas the typical self-assembly was not systematically observed from other peptides with or without coupling. The critical aggregation concentration that allows the BIOT-NFL-peptide to aggregate and auto associate was determined at 10-4 mol/L by surface tension measurements. X-ray scattering of BIOT-NFL-peptide also demonstrated its beta-sheet structure that can facilitate the intermolecular interactions involved in the self-assembly process. The possible disassembly of self-assembled BIOT-NFL-peptide-nanofibers was examined via a dialysis membrane study. We further investigated the interaction between nanofibers formed by BIOT-NFL-peptide and gold nanoparticles. Interestingly, a strong interaction was demonstrated between these nanoparticles and BIOT-NFL-peptide resulted in the formation of BIOT-NFL-peptide-nanofibers grandly decorated by gold nanoparticles. Finally, we investigated the internalization of gold nanoparticles coupled with BIOT-NFL-nanofibers into F98 rat glioblastoma cells, which was increased compared to the non-coupled control gold nanoparticles. All these results indicate that this peptide could be a promising therapeutic agent for targeted delivery.

Biot number

Internalization

10.1016/j.ijpx.2022.100128

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Citations (7)

New practical approach of integrated photonic based on biomimetic peptidic/silica self-assembled nanotubes

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2009)

Daphné Duval Christophe Tarabout N. Huby Franck Artzner Étienne Gaviot

We report on the first developments for a new approach of integrated photonic using optical evanescent coupling from organic microstructures to bundles of hybrid nanotubes (NT). Microstructures are organic disks acting as photon reservoirs, integrated on a photonic chip fabricated by micro-technologic processes. Biomimetic peptidic/ silica nanotubes are realized by molecular self-assembly allowing high aspect ratio. Such heterostructures have been included directly on the organic chip as an innovative solution based on nanotubes in situ chipapproach. The latter allowed us to obtain an adequate evanescent coupling localized between micronic-disks and bundles of nanotubes. As a result, we highlight a specific photonic propagation along various heterostructured- NT-bundles featuring distances beyond the centimeter and losses from 1.2 to 6.6 dB/cm. It presents an advantageous confinement of the optical mode marked with strong energy localizations between nanotubes.

Characterization

10.1117/12.805500

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Anomalous dynamics of water at the octopeptide lanreotide surface

RSC Advances (2020)

Florian Pinzan Franck Artzner Aziz Ghoufi

This work reports the study of water dynamics close to the cyclic octapeptide lanreotide from atomistic simulations of hydrated lanreotide, a cyclic octapeptide. Calculation of the hydrogen bonds between water molecules allows mapping of the hydrophilic regions of lanreotide. Whereas a super-diffusivity of the interfacial water molecules is established, a slowdown in rotational dynamics is observed, involving a decoupling between both processes. Acceleration in translation dynamics is connected to the hopping process between hydrophilic zones. Microscopically, this is correlated with the weakness of the interfacial hydrogen bonding network due to a hydrophobic interface at the origin of the interfacial sliding of water molecules. Heterogeneous rotational dynamics of water molecules close the lanreotide surface is evidenced and connected to heterogeneous hydration.

Slowdown

Dynamics

Lanreotide

10.1039/d0ra06237e

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Calibration and quality assurance procedures at the far UV linear and circular dichroism experimental station DISCO

Journal of Physics Conference Series (2013)

Frank Wien Maı̈té Paternostre Frédéric Gobeaux Franck Artzner Matthieu Réfregiers

Circular and Linear dichroism spectroscopy used in biophysics, are both differential absorption techniques, which explore the chirality of complex macromolecular structures such as proteins and nucleic acids in solution. In the past two decades synchrotron radiation facilities throughout the world, have accommodated circular dichroism (SRCD) experiments. These intense VUV light sources have greatly expanded the wavelength range exploitable (down to 120nm) at high constant photon flux improving signal to noise ratio and data acquisition speed. Here we present the calibration procedure for the circular and linear dichroism experiments explored on the SRCD beam line DISCO at the synchrotron SOLEIL as well as the specially designed automated sample rotation chamber.

Linear dichroism

10.1088/1742-6596/425/12/122014

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Citations (11)

Fonctionnalisation et biominéralisation de nano-objets

HAL (Le Centre pour la Communication Scientifique Directe) (2007)

Franck Artzner

Source

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Des nanotubes de verre qui se fabriquent tous seuls...

HAL (Le Centre pour la Communication Scientifique Directe) (2007)