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Valérie Mils

Université Toulouse III - Paul Sabatier

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Nicole Basset‐Séguin

Hôpital Saint-Louis

Jean‐Jacques Guilhou

Centre Hospitalier Universitaire de Montpellier

Jean‐Pierre Molès

Inserm

Pascale Belenguer

Université Toulouse III - Paul Sabatier

Guy Serre

Centre National de la Recherche Scientifique

O. Dereure

Inserm

Bernard Ducommun

Centre National de la Recherche Scientifique

Véronique Baldin

Centre National de la Recherche Scientifique

Marlène Daloyau

Université Toulouse III - Paul Sabatier

Christian Vincent

Centre National de la Recherche Scientifique

Cooperative Institutions

Centre National de la Recherche Scientifique

Université Toulouse III - Paul Sabatier

Inserm

Université de Toulouse

Centre de Biologie du Développement

Université de Montpellier

Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération

Centre de Recherches sur la Cognition Animale

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Institut de Génétique Moléculaire de Montpellier

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Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

Oncogene (2000)

Valérie Mils Véronique Baldin F Goubin Isabelle Pinta Catherine Papin

Cdc25

CDC25A

Dephosphorylation

10.1038/sj.onc.1203419

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Citations (105)

Les phosphatases CDC25 : régulateurs du cycle cellulaire et oncogènes potentiels.

médecine/sciences (1998)

Christophe Cans Véronique Baldin Valérie Mils Bernard Ducommun

Les phosphatases CDC25 a double specificite (phosphotyrosine et phosphoserine/threonine) activent les kinases regulatrices du cycle cellulaire (les CDK) et controlent ainsi le declenchement de l'entree en mitose et la proliferation. La regulation de l'activite de ces phosphatases depend de voies de signalisation impliquant les produits des proto-oncogenes Ras, Raf et Myc, et des deregulations de leur expression pourraient avoir des consequences oncogeniques. La recherche d'inhibiteurs specifiques des phosphatases CDC 25 ouvre des perspectives pharmacologiques antitumorales nouvelles.

Cdc25

10.4267/10608/1029

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Citations (1)

LIM-only protein FHL3 interacts with CDC25B2 phosphatase

Experimental Cell Research (2003)

Valérie Mils Simon Ming‐Yuen Lee Willy Joly Chi Hang Wong Véronique Baldin

C2C12

10.1016/s0014-4827(03)00018-1

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Citations (11)

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

Neurobiology of Disease (2015)

Ambre M. Bertholet Thomas Delerue Aurélie Millet Manon Moulis Claudine David

MFN1

Organelle

10.1016/j.nbd.2015.10.011

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Citations (306)

TP53 Tumor Suppressor Gene and Skin Carcinogenesis.

Journal of Investigative Dermatology (1994)

Nicole Basset‐Séguin Jean‐Pierre Molès Valérie Mils O. Dereure Jean‐Jacques Guilhou

10.1111/1523-1747.ep12399372

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Citations (4)

MDM-2 protein is expressed in different layers of normal human skin

Oncogene (1997)

Jean-Eudes Dazard Didier Augias Henry Neel Valérie Mils Vincent Maréchal

Epidermis (zoology)

Human skin

P53 protein

10.1038/sj.onc.1200922

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Citations (24)

Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle

Springer eBooks (1989)

Guy Serre Valérie Mils Christian Vincent A. Conter Sylvie Michel

Stratum granulosum

Epidermis (zoology)

Inner root sheath

Stratified squamous epithelium

Immunofluorescence

Human skin

10.1007/978-94-011-7873-0_5

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Citations (1)

The expression of desmosomal and corneodesmosomal antigens shows specific variations during the terminal differentiation of epidermis and hair follicle epithelia.

Journal of Histochemistry & Cytochemistry (1992)

Valérie Mils Christian Vincent F. Croute Guy Serre

Using five monoclonal antibodies (MAb), we studied by indirect immunofluorescence the desmosomes and a junctional structure specific to cornified layers, the corneodesmosome, in normal and plantar epidermis and in the various sheaths of the anagen hair follicle. The monoclonal antibodies DP1&2.2-15, PG5.1, and DG3.10, specific for desmoplakins I/II, plakoglobin, and desmoglein I, respectively, were used to study the desmosome antigens, and G36-19 and G20-21 to study the corneodesmosome antigens. The distribution and sequence of expression of the five antigens allowed the nine epithelial differentiation pathways studied to be merged into four distinct families: non-plantar epidermis, characterized by the absence of desmosome and corneodesmosome antigens in the stratum corneum; the outer root sheath of the hair follicle, which behaves like the viable layers of the epidermis with regard to the desmosome antigens but does not express the corneodesmosome antigens; plantar epidermis and the three components of the inner root sheath in which the corneodesmosome antigens are present up to the desquamating layer; and the three components of the hair shaft, which are characterized by the absence of expression of both the desmosome and the corneodesmosome antigens in its mature portion.

Desmosome

Epidermis (zoology)

Desmoglein

Desmoglein 3

Plakoglobin

Stratum granulosum

10.1177/40.9.1506670

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Citations (51)

Mitochondrial Reshaping Accompanies Neural Differentiation in the Developing Spinal Cord

PLoS ONE (2015)

Valérie Mils Stéphanie Bosch Julie Roy Sophie Bel-Vialar Pascale Belenguer

Mitochondria, long known as the cell powerhouses, also regulate redox signaling and arbitrate cell survival. The organelles are now appreciated to exert additional critical roles in cell state transition from a pluripotent to a differentiated state through balancing glycolytic and respiratory metabolism. These metabolic adaptations were recently shown to be concomitant with mitochondrial morphology changes and are thus possibly regulated by contingencies of mitochondrial dynamics. In this context, we examined, for the first time, mitochondrial network plasticity during the transition from proliferating neural progenitors to post-mitotic differentiating neurons. We found that mitochondria underwent morphological reshaping in the developing neural tube of chick and mouse embryos. In the proliferating population, mitochondria in the mitotic cells lying at the apical side were very small and round, while they appeared thick and short in interphase cells. In differentiating neurons, mitochondria were reorganized into a thin, dense network. This reshaping of the mitochondrial network was not specific of a subtype of progenitors or neurons, suggesting that this is a general event accompanying neurogenesis in the spinal cord. Our data shed new light on the various changes occurring in the mitochondrial network during neurogenesis and suggest that mitochondrial dynamics could play a role in the neurogenic process.

10.1371/journal.pone.0128130

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Citations (21)

TP53 Tumor Suppressor Gene and Skin Carcinogenesis.

Journal of Investigative Dermatology (1994)

Nicole Basset‐Séguin Jean‐Pierre Molès Valérie Mils O. Dereure Jean‐Jacques Guilhou

Malignant Transformation

10.1111/1523-1747.ep12399372

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Citations (74)