K Bodtke

LungenClinic Grosshansdorf

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Endosonographisches Lymphknoten-Staging des Lungenkarzinoms in der täglichen Praxis

Pneumologie (2018)

R Claussen K Bodtke Lutz Welker Christian Kügler Klaus F. Rabe

Das mediastinale Lymphknoten (LK)-Staging des Lungenkarzinoms durch endobronchialen (EBUS) und ösophagealen (EUS) Ultraschall hat sich durch die Ergebnisse zahlreicher Studien etabliert. Ziel unserer Untersuchung war eine Überprüfung der Aussagekraft der Endosonografie (ES) in der täglichen Praxis einer Lungenfachklinik.

Praxis

10.1055/s-0037-1619230

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Citations (0)

Up-regulation of human eosinophil leukotriene C 4 generation through contact with bronchial epithelial cells

Inflammation Research (2000)

Gordon Dent E. Rühlmann K Bodtke H Magnussen Klaus F. Rabe

Platelet-activating factor

Leukotriene B4

Leukotriene C4

Respiratory tract

10.1007/s000110050585

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Citations (14)

Cyclic Nucleotide Phosphodiesterase in Human Bronchial Epithelial Cells: Characterization of Isoenzymes and Functional Effects of PDE Inhibitors

Pulmonary Pharmacology & Therapeutics (1998)

Gordon Dent S.R. White Herman Tenor K Bodtke Christian Schudt

Rolipram

IBMX

Phosphodiesterase 3

Second messenger system

10.1006/pupt.1998.0115

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Citations (48)

Role of IgE in hyperresponsiveness induced by passive sensitization of human airways.

American Journal of Respiratory and Critical Care Medicine (1997)

N. Watson K Bodtke Ronan Coleman Gordon Dent B. E. Morton

Incubation of airways from nonatopic patients with serum from patients with high IgE levels confers responsiveness to "specific" (allergen) and hyperresponsiveness to "nonspecific" (histamine) stimuli. We have tested the hypothesis that the level of IgE determines the degree of specific and nonspecific responsiveness. Bronchial rings from nonatopic patients were sensitized overnight with serum containing high levels of allergen-specific IgE, or with an allergen-specific chimeric IgE (JW8) in physiologic buffer. In vitro responsiveness to allergen and histamine was evaluated and compared with non-sensitized tissues from the same patients. Responses to specific allergen were demonstrated in all tissues sensitized with atopic serum or chimeric IgE, but not in nonsensitized tissues. Allergen responses were specific, since tissues sensitized using serum containing high Dermatohagoides farinae-specific IgE only, did not respond to either horse or dog allergens. The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Therefore, specific IgE determines allergen responsiveness in passively sensitized human airways, but histamine hyperresponsiveness is independent of specific IgE and appears to be related to some other factor associated with serum containing high concentrations of total IgE.

10.1164/ajrccm.155.3.9117014

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Citations (63)